National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Intersectin-1 |
| Accession Code | Q9WVE9 |
| Gene | Itsn1 |
| Organism | Rattus norvegicus | Norway rat (Taxonomy: 10116) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 1713) |
Structure Viewer (PDB: 3HS9) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles (PubMed:20448150). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (By similarity). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines (By similarity). Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (PubMed:23633571). Inhibits ARHGAP31 activity toward RAC1 (By similarity). {By SimilarityUniProtKB:Q15811, By SimilarityUniProtKB:Q9Z0R4, Experimental EvidencePubMed:20448150, Experimental EvidencePubMed:23633571}. [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons. {By SimilarityUniProtKB:Q9Z0R4}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (1 interactors) |
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Interactions with other proteins (6 interactors) |
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Database | Links |
| UNIPROT | Q9WVE9 D3ZV52 F1M823 Q9WVE1 |
| PDB | 3HS9 |
| Pfam | PF00168 PF12763 PF16617 PF16652 PF00621 PF00018 PF07653 PF14604 |
| PROSITE | PS50004 PS00741 PS50010 PS00018 PS50222 PS50031 PS50003 PS50002 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory