NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Adenomatous polyposis coli protein 2 - Mus musculus - NucEnvDB

Adenomatous polyposis coli protein 2 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Adenomatous polyposis coli protein 2
Accession Code	Q9Z1K7
Gene	Apc2
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 2274)
MTSSMASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQTDISSLYNLKFHAPALGPEPAARTPEGSPVHGSGPSKDSFGELSRATIRL LEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAVKPVAVEEEQEAEVPTHP EDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRAGIPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQAR DSGTETPVPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLGSESEELHQVVSSILRNLSWRADINSKKV LREVGSMTALMECVLRASKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSP RDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQAAAMAVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQSLPEAETTSKKPLPPLRHLDGLVQDYASDSGCFDDDDAPSLA AAATTAEPASPAVMSMFLGGPFLQGQALARTPPARQGGLEAEKEAGGEAAVAAKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAA HTSLSNDSLNSGSTSDGYCTREHMTPCPLAALAEHRDDPVRGQTRPRRLDLDLPSRAELPARDTAATDARVRTIKLSPTYQHVPLLDGAAGAGVRPLVGPGTSPGARKQAWIPADSLSKVPEKLVASPLP IASKVLQKLVAQDGPMSLSRCSSLSSLSSTGHAVPSQAENLDSDSSLEGLEEAGPGEAELGRAWRASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESRSIASSI PSDPCSGLGSGTVSPSELPDSPGQTMPPSRSKTPPAPPGQPETSQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQQDVELRLRPPACPERAVGGGGHRR RDEAASRLDGPAPAGSRARSATDKELEALRECLGAAMPARLRKVASALVPGRRSLPVPVYMLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETLQGPSRDKPAGPGDRQKPTGRAAPARQTRSHRPKAA GAGKSTEHTRGPCRNRAGLELPLSRPQSARSNRDSSCQTRTRGDGALQSLCLTTPTEEAVYCFYDSDEEPPATAPPPRRASAIPRALKREKPAGRKETPSRAAQPATLPVRAQPRLIVDETPPCYSLTSS ASSLSEPEAPEQPANHARGPEQGSKQDSSPSPRAEEELLQRCISLAMPRRRTQVPGSRRRKPRALRSDIRPTEITQKCQEEVAGSDPASDLDSVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLS LVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRLPNGPEKAKGTQKMMAGESTMLRGRTVIYSAGPASRTQSKGISGPCTTPKKTGTSGTTQPETVTKAPSPEQQRSRSLHRPGKI SELAALRHPPRSATPPARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGSLVPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVRMASAR SSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTASTSQAASPRRGRPALPAVFLCSSRCDELRVSPRQPLAAQRSPQAKPGLAPLAPRRTSSESPSRLPVRASPGRPETVKRYASLPHISVSRR SDSAVSVPTTQANATRRGSDGEARPLPRVAPPGTTWRRIKDEDVPHILRSTLPATALPLRVSSPEDSPAGTPQRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPASGPVAPQGSDVDGPVLTKPPA SAPFPHEGLSAVIAGFPTSRHGSPSRAARVPPFNYVPSPMAAATMASDSAVEKAPVSSPASLLE

Subcellular Location

Description
Cytoplasm, cytoskeleton {By SimilarityUniProtKB:O95996}. Golgi apparatus {By SimilarityUniProtKB:O95996}. Cytoplasm {By SimilarityUniProtKB:O95996}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:O95996}. Note=Associated with actin filaments. Associated with microtubule network. {By SimilarityUniProtKB:O95996}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Actin Filament (GO:0005884) Beta-Catenin Destruction Complex (GO:0030877) Catenin Complex (GO:0016342) Cytoplasm (GO:0005737) Cytoplasmic Microtubule (GO:0005881) Cytosol (GO:0005829) Filamentous Actin (GO:0031941) Golgi Apparatus (GO:0005794) Intercellular Bridge (GO:0045171) Lamellipodium Membrane (GO:0031258) Microtubule Cytoskeleton (GO:0015630) Midbody (GO:0030496) Perinuclear Region Of Cytoplasm (GO:0048471) Postsynapse (GO:0098794)

Biology & Function

Description
Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1. {By SimilarityUniProtKB:O95996}.
Assigned Ontology terms

Biological Process	Activation Of GTPase Activity (GO:0090630) Cell Fate Specification (GO:0001708) Cell Migration (GO:0016477) Microtubule Cytoskeleton Organization (GO:0000226) Negative Regulation Of Canonical Wnt Signaling Pathway (GO:0090090) Negative Regulation Of Microtubule Depolymerization (GO:0007026) Nervous System Development (GO:0007399) Pattern Specification Process (GO:0007389) Positive Regulation Of Protein Catabolic Process (GO:0045732) Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process (GO:0043161) Regulation Of Cell Differentiation (GO:0045595) Wnt Signaling Pathway (GO:0016055)
Molecular Function	Beta-Catenin Binding (GO:0008013) Gamma-Catenin Binding (GO:0045295) Microtubule Binding (GO:0008017)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P35922	Fragile X messenger ribonucleoprotein 1	EBI-16728828	0.35

Cross-References

Database	Links
UNIPROT	Q9Z1K7
Pfam	PF05956 PF16689 PF05923 PF18797 PF00514 PF05924

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