Interactions with Nuclear Envelope proteins (8 interactors)
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Partner (NucEnvDB) IntAct Confidence score
O60238 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like EBI-850662 0.44
P10415 Self EBI-700826 0.59
Q12982 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 EBI-849945 0.37
Q86Y07 Serine/threonine-protein kinase VRK2 EBI-1207847 0.37
P11881 Inositol 1,4,5-trisphosphate receptor type 1 EBI-15801106 0.52
Q14643 Inositol 1,4,5-trisphosphate receptor type 1 EBI-15801089 0.40
Q13625 Apoptosis-stimulating of p53 protein 2 EBI-15723849 0.65
Q07817 Bcl-2-like protein 1 EBI-2126646 0.44
Interactions with other proteins (56 interactors)
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Partner (UniProt) IntAct Confidence score
O54918 Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) EBI-707531 0.44
Q9DAJ5 Dynein light chain roadblock-type 2 (Dynein light chain 2B, cytoplasmic) EBI-526356 0.35
P51572 B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28) EBI-77682 0.52
P28482 Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) EBI-7210282 0.49
P67775 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) EBI-7210303 0.49
P45983 Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) EBI-7497436 0.31
Q14318 Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) EBI-7497544 0.51
P55957 BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] EBI-519684 0.87
Q9BXH1 Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis) EBI-707957 0.82
P63098 Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) EBI-7517885 0.49
Q07813 Apoptosis regulator BAX EBI-700706 0.40
Q07812 Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) EBI-700753 0.94
Q16611 Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) EBI-700762 0.61
Q92934 Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) EBI-700785 0.81
Q13323 Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4) EBI-700803 0.82
O43521 Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) EBI-707839 0.92
Q91ZE9 Bcl-2-modifying factor EBI-708044 0.62
Q61337 Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) EBI-709166 0.72
Q12983 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 EBI-849952 0.37
O60551 Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Protein-lysine myristoyltransferase NMT2) (EC 2.3.1.-) (Type II N-myristoyltransferase) EBI-8173465 0.40
Q63690 Apoptosis regulator BAX EBI-8496082 0.40
P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) EBI-1206840 0.00
P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) EBI-1207036 0.00
P62140 Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) EBI-1207176 0.00
Q9C000 NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)] EBI-1246113 0.75
Q14457 Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] EBI-5234827 0.95
Q9H2V7 Protein spinster homolog 1 (HSpin1) (Spinster-like protein 1) EBI-1386538 0.46
O15304 Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) EBI-1393040 0.40
Q14790 Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] EBI-1749080 0.37
P22736 Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3) EBI-2126295 0.67
P04637 Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) EBI-7044574 0.56
O15151 Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) EBI-7044604 0.50
Q8N5K1 CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1) EBI-7676229 0.54
Q0WGQ5 Putative sugar ABC transporter EBI-2874959 0.00
P27797 Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) EBI-8537109 0.35
P38646 Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) EBI-8537109 0.35
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT) EBI-8537109 0.35
Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3) EBI-8600088 0.66
Q13794 Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa) EBI-4370379 0.54
Q96LC9 Bcl-2-modifying factor EBI-5488187 0.40
P29117 Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Rotamase F) EBI-6465503 0.40
P30405 Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F) EBI-6465542 0.37
Q9NYF8 Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1) EBI-6621256 0.50
P38398 Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) EBI-8757170 0.38
P0DM65 Beclin-2 EBI-8839562 0.40
A8MW95 Beclin-2 (Beclin-1 autophagy-related pseudogene 1) (Beclin-1-like protein 1) EBI-8839552 0.40
Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin) EBI-10055396 0.44
Q7L3V2 Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) EBI-11509550 0.35
P21796 Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) EBI-15801214 0.40
Q92570 Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) EBI-20939354 0.40
P59635 ORF7a protein (Accessory protein 7a) (Protein U122) (Protein X4) EBI-25495801 0.40
P00441 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1) EBI-25934648 0.56
P05067 Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] EBI-25936674 0.56
Q9HB09 Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein) EBI-27086233 0.37
Q13619 Cullin-4A (CUL-4A) EBI-30863570 0.35
Q8WV16 DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A) EBI-30863977 0.35
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory