Nucleoprotein - Severe acute respiratory syndrome-related coronavirus

Nucleoprotein (Severe acute respiratory syndrome-related coronavirus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Nucleoprotein
Accession Code	P59595
Gene	N
Organism	Severe acute respiratory syndrome-related coronavirus (Taxonomy: 694009)
Part of Reference Proteome?	Yes
Sequence (Length: 422)
MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQHGKEELRFPRGQGVPINTNSG PDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEASLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVL QLPQGTTLPKGFYAEGSRGGSQASSRSSSRSRGNSRNSTPGSSRGNSPARMASGGGETALALLLLDRLNQLESKVSGKGQ QQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFGDQDLIRQGTDYKHWPQIAQFAPSASAFFGMSR IGMEVTPSGTWLTYHGAIKLDDKDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTDEAQPLPQRQKKQPTVTLLPAAD MDDFSRQLQNSMSGASADSTQA

Structure Viewer (PDB: 2JW8)

Subcellular Location

Description
Virion {Sequence AnalysisHAMAP-Rule:MF_04096, Experimental EvidencePubMed:17210170, Experimental EvidencePubMed:19106108}. Host endoplasmic reticulum-Golgi intermediate compartment {Sequence AnalysisHAMAP-Rule:MF_04096, Experimental EvidencePubMed:17210170}. Host Golgi apparatus {Sequence AnalysisHAMAP-Rule:MF_04096, Experimental EvidencePubMed:17210170}. Host cytoplasm, host perinuclear region {Experimental EvidencePubMed:17210170}. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding. {Sequence AnalysisHAMAP-Rule:MF_04096}.
Position in the Nuclear Envelope
Location	Location ID	Description
Host Perinuclear Region	SL-0382	The host perinuclear region is the host cytoplasmic region just around the host nucleus. Note: This location is defined for viral proteins that appear in the perinuclear region of infected host cells
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Host Cell Endoplasmic Reticulum-Golgi Intermediate Compartment (GO:0044172) Host Cell Golgi Apparatus (GO:0044177) Host Cell Perinuclear Region Of Cytoplasm (GO:0044220) Plasma Membrane (GO:0005886) Ribonucleoprotein Complex (GO:1990904) Viral Capsid (GO:0019028) Viral Nucleocapsid (GO:0019013)

Biology & Function

Description
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (PubMed:17210170). May modulate transforming growth factor-beta signaling by binding host SMAD3 (PubMed:18055455). {Sequence AnalysisHAMAP- Rule:MF_04096, Experimental EvidencePubMed:17210170, Experimental EvidencePubMed:18055455}.
Assigned Ontology terms

Biological Process	Viral RNA Genome Packaging (GO:0019074)
Molecular Function	DNA Binding (GO:0003677) Identical Protein Binding (GO:0042802) Molecular Adaptor Activity (GO:0060090) RNA Binding (GO:0003723)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (15 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O75569	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	EBI-25639357	0.54
P63165	Small ubiquitin-related modifier 1	EBI-7602710	0.54
P59595	Self	EBI-7602801	0.98
P63279	SUMO-conjugating enzyme UBC9	EBI-25497306	0.75
Q8NEF9	Serum response factor-binding protein 1	EBI-27129966	0.35
Q8NDT2	Putative RNA-binding protein 15B	EBI-27129966	0.35
Q9BVI4	Nucleolar complex protein 4 homolog	EBI-27129966	0.35
Q9Y224	RNA transcription, translation and transport factor protein	EBI-27129966	0.35
Q9H6S0	3'-5' RNA helicase YTHDC2	EBI-27129966	0.35
O43709	Probable 18S rRNA (guanine-N(7))-methyltransferase	EBI-27129966	0.35
P24385	G1/S-specific cyclin-D1	EBI-25746873	0.58
Q96C57	Protein CUSTOS	EBI-27129966	0.35
P19525	Interferon-induced, double-stranded RNA-activated protein kinase	EBI-26984718	0.40
Q9UII4	E3 ISG15--protein ligase HERC5	EBI-27129966	0.35
Q14244	Ensconsin	EBI-27129966	0.35
Interactions with other proteins (240 interactors)

Partner (UniProt)		IntAct	Confidence score
P09651	Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]	EBI-7613676	0.60
P61769	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	EBI-25487169	0.52
P59596	Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)	EBI-25493215	0.91
Q05639	Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1)	EBI-25498109	0.69
P62937	Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]	EBI-25499625	0.68
P13645	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)	EBI-25635560	0.35
P04264	Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)	EBI-25635560	0.35
P62333	26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)	EBI-25635560	0.56
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.38) (APOBEC-related cytidine deaminase) (APOBEC-related protein) (ARCD) (APOBEC-related protein 9) (ARP-9) (CEM-15) (CEM15) (Deoxycytidine deaminase) (A3G)	EBI-25641899	0.40
P59637	Envelope small membrane protein (E protein) (sM protein)	EBI-25668008	0.57
P84022	Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)	EBI-25682920	0.40
P84025	Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3)	EBI-25683178	0.52
P24941	Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)	EBI-25746912	0.35
P20248	Cyclin-A2 (Cyclin-A) (Cyclin A)	EBI-25746912	0.35
P59594	Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2']	EBI-25823635	0.27
Q9Y3U8	60S ribosomal protein L36 (Large ribosomal subunit protein eL36)	EBI-26376911	0.35
Q9HCE1	Helicase MOV-10 (EC 3.6.4.13) (Armitage homolog) (Moloney leukemia virus 10 protein)	EBI-26376911	0.35
P68400	Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)	EBI-26376911	0.35
P11940	Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)	EBI-26376911	0.53
O76021	Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)	EBI-26376911	0.35
Q9UN86	Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)	EBI-26376911	0.74
Q9BQ75	Protein CMSS1 (Cms1 ribosomal small subunit homolog)	EBI-26376911	0.53
Q8TAD8	Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1)	EBI-26376911	0.53
Q8NCA5	Protein FAM98A	EBI-26376911	0.53
Q86U42	Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)	EBI-26376911	0.35
Q6PKG0	La-related protein 1 (La ribonucleoprotein domain family member 1)	EBI-26376911	0.53
Q13310	Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)	EBI-26376911	0.53
Q13283	Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)	EBI-26376911	0.89
P67870	Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)	EBI-26376911	0.35
P19784	Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)	EBI-26376911	0.35
P16989	Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)	EBI-26376911	0.53
O75683	Surfeit locus protein 6	EBI-26376911	0.53
O43818	U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K)	EBI-26376911	0.35
Q92831	Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)	EBI-26971417	0.44
Q92830	Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)	EBI-26971428	0.44
Q14258	E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)	EBI-27086792	0.46
P23249	Putative helicase MOV-10 (EC 3.6.4.13) (Moloney leukemia virus 10 protein)	EBI-27090990	0.40
Q14011	Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP)	EBI-27129966	0.35
Q8WU68	Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3)	EBI-27129966	0.35
Q13585	Melatonin-related receptor (G protein-coupled receptor 50) (H9)	EBI-27129966	0.35
Q8TBB5	Kelch domain-containing protein 4	EBI-27129966	0.35
Q9Y388	RNA-binding motif protein, X-linked 2	EBI-27129966	0.35
P20719	Homeobox protein Hox-A5 (Homeobox protein Hox-1C)	EBI-27129966	0.35
Q9NWT1	p21-activated protein kinase-interacting protein 1 (PAK/PLC-interacting protein 1) (hPIP1) (PAK1-interacting protein 1) (WD repeat-containing protein 84)	EBI-27129966	0.35
E9PRG8	Uncharacterized protein C11orf98	EBI-27129966	0.35
Q96G21	U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) (Brix domain-containing protein 4)	EBI-27129966	0.35
Q96EU6	Ribosomal RNA processing protein 36 homolog	EBI-27129966	0.35
Q96P11	28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)	EBI-27129966	0.35
Q9P2D0	Inhibitor of Bruton tyrosine kinase (IBtk)	EBI-27129966	0.35
Q8WY91	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4)	EBI-27129966	0.35
Q9NQV6	PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin)	EBI-27129966	0.35
Q32NC0	UPF0711 protein C18orf21 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13)	EBI-27129966	0.35
Q9BY49	Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP) (HPDHase) (Short chain dehydrogenase/reductase family 29C member 1) (pVI-ARL)	EBI-27129966	0.35
Q9Y6Y1	Calmodulin-binding transcription activator 1	EBI-27129966	0.35
Q86XN8	RNA-binding protein MEX3D (RING finger and KH domain-containing protein 1) (RING finger protein 193) (TINO)	EBI-27129966	0.35
Q9NP64	Zinc finger CCHC domain-containing protein 17 (Nucleolar protein of 40 kDa) (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein)	EBI-27129966	0.35
Q9Y3A2	Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein)	EBI-27129966	0.35
Q03188	Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7)	EBI-27129966	0.35
A6NFI3	Zinc finger protein 316	EBI-27129966	0.35
Q8WUQ7	Cactin (Renal carcinoma antigen NY-REN-24)	EBI-27129966	0.35
O15213	WD repeat-containing protein 46 (WD repeat-containing protein BING4)	EBI-27129966	0.35
Q5T280	Putative methyltransferase C9orf114 (EC 2.1.1.-) (Centromere protein 32) (CENP-32) (Kinetochore-associated protein) (SPOUT domain-containing methyltransferase 1)	EBI-27129966	0.35
Q96EZ8	Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2)	EBI-27129966	0.35
O14647	Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2)	EBI-27129966	0.35
A8MTY0	Zinc finger protein 724	EBI-27129966	0.35
Q8IUH3	RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45)	EBI-27129966	0.35
Q8IYN0	Zinc finger protein 100	EBI-27129966	0.35
Q86Y79	Probable peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)	EBI-27129966	0.35
Q15397	Pumilio homolog 3 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8)	EBI-27129966	0.35
Q14191	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 3.6.4.12)]	EBI-27129966	0.35
Q8TF76	Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase)	EBI-27129966	0.35
Q8NB50	Zinc finger protein 62 homolog (Zfp-62)	EBI-27129966	0.35
O95251	Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)	EBI-27129966	0.35
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291)	EBI-27129966	0.35
A0AV96	RNA-binding protein 47 (RNA-binding motif protein 47)	EBI-27129966	0.35
Q6NUN9	Zinc finger protein 746 (Parkin-interacting substrate) (PARIS)	EBI-27129966	0.35
Q9P1Y6	PHD and RING finger domain-containing protein 1	EBI-27129966	0.35
Q14119	Vascular endothelial zinc finger 1 (Putative transcription factor DB1) (Zinc finger protein 161)	EBI-27129966	0.35
Q6P1M3	LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)	EBI-27129966	0.35
Q96GY0	Zinc finger C2HC domain-containing protein 1A	EBI-27129966	0.35
Q13574	Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta)	EBI-27129966	0.35
Q8NI77	Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A)	EBI-27129966	0.35
Q9UH17	DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3)	EBI-27129966	0.35
O75525	KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein)	EBI-27129966	0.35
P49759	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)	EBI-27129966	0.35
Q13523	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)	EBI-27129966	0.35
Q9HAZ1	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)	EBI-27129966	0.35
Q8N567	Zinc finger CCHC domain-containing protein 9	EBI-27129966	0.35
Q16698	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1)	EBI-27129966	0.35
Q9H7N4	Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)	EBI-27129966	0.35
Q12873	Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)	EBI-27129966	0.35
Q9NV31	U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) (BRMS2)	EBI-27129966	0.35
Q14147	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) (DExH-box helicase 34)	EBI-27129966	0.35
Q149N8	E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)	EBI-27129966	0.35
Q02880	DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)	EBI-27129966	0.35
Q96BK5	PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)	EBI-27129966	0.35
Q9H9Y2	Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1)	EBI-27129966	0.35
Q9P0L2	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)	EBI-27129966	0.35
Q12986	Transcriptional repressor NF-X1 (EC 2.3.2.-) (Nuclear transcription factor, X box-binding protein 1)	EBI-27129966	0.35
Q9UKM9	RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)	EBI-27129966	0.35
Q8N5F7	NF-kappa-B-activating protein	EBI-27129966	0.35
O95625	Zinc finger and BTB domain-containing protein 11	EBI-27129966	0.35
Q96K58	Zinc finger protein 668	EBI-27129966	0.35
Q9NQZ2	Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog)	EBI-27129966	0.35
Q96MX3	Zinc finger protein 48 (Zinc finger protein 553)	EBI-27129966	0.35
Q14CB8	Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19)	EBI-27129966	0.35
Q15776	Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (Zinc finger protein 192)	EBI-27129966	0.35
Q9GZR2	RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2)	EBI-27129966	0.35
O75330	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)	EBI-27129966	0.35
Q709F0	Acyl-CoA dehydrogenase family member 11 (ACAD-11) (EC 1.3.8.-)	EBI-27129966	0.35
Q9Y3Y2	Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)	EBI-27129966	0.35
Q9NUL7	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28)	EBI-27129966	0.35
Q5VWQ0	Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1)	EBI-27129966	0.35
P49761	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)	EBI-27129966	0.35
Q9H6R4	Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap)	EBI-27129966	0.35
Q9NY61	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1)	EBI-27129966	0.35
Q9H8H2	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.4.13) (DEAD box protein 31) (Helicain)	EBI-27129966	0.35
Q9Y2P8	RNA 3'-terminal phosphate cyclase-like protein	EBI-27129966	0.35
Q5BKZ1	DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1)	EBI-27129966	0.35
P07305	Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed]	EBI-27129966	0.35
Q6NZI2	Caveolae-associated protein 1 (Cavin-1) (Polymerase I and transcript release factor)	EBI-27129966	0.35
Q9H7B2	Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog)	EBI-27129966	0.35
O00566	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10)	EBI-27129966	0.35
O94761	ATP-dependent DNA helicase Q4 (EC 3.6.4.12) (DNA helicase, RecQ-like type 4) (RecQ4) (RTS) (RecQ protein-like 4)	EBI-27129966	0.35
Q9NUQ6	SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP)	EBI-27129966	0.35
Q14680	Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)	EBI-27129966	0.35
P78332	RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3)	EBI-27129966	0.35
Q9Y4F1	FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)	EBI-27129966	0.35
Q8WXF0	Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)	EBI-27129966	0.35
Q5VYS8	Terminal uridylyltransferase 7 (TUTase 7) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 6)	EBI-27129966	0.35
Q96PU8	Protein quaking (Hqk) (HqkI)	EBI-27129966	0.35
O95453	Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)	EBI-27129966	0.35
Q9UL40	Zinc finger protein 346 (Just another zinc finger protein)	EBI-27129966	0.35
Q15050	Ribosome biogenesis regulatory protein homolog	EBI-27129966	0.35
P49840	Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)	EBI-27129966	0.35
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)	EBI-27129966	0.35
P11388	DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)	EBI-27129966	0.35
Q9H5H4	Zinc finger protein 768	EBI-27129966	0.35
Q9HC36	rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1)	EBI-27129966	0.35
Q9H6F5	Coiled-coil domain-containing protein 86 (Cytokine-induced protein with coiled-coil domain)	EBI-27129966	0.35
Q9H7H0	Methyltransferase-like protein 17, mitochondrial (EC 2.1.1.-) (False p73 target gene protein) (Methyltransferase 11 domain-containing protein 1) (Protein RSM22 homolog, mitochondrial)	EBI-27129966	0.35
Q9ULW3	Activator of basal transcription 1 (hABT1) (Basal transcriptional activator)	EBI-27129966	0.35
Q8IYB3	Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)	EBI-27129966	0.35
Q6PK04	Coiled-coil domain-containing protein 137	EBI-27129966	0.35
Q9UGR2	Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN)	EBI-27129966	0.35
Q49A26	Cytokine-like nuclear factor N-PAC (NPAC) (3-hydroxyisobutyrate dehydrogenase-like protein) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) (Nuclear protein of 60 kDa) (Nucleosome-destabilizing factor) (hNDF) (Putative oxidoreductase GLYR1)	EBI-27129966	0.35
O94813	Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]	EBI-27129966	0.35
Q9Y5J1	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50)	EBI-27129966	0.35
Q9BXS6	Nucleolar and spindle-associated protein 1 (NuSAP)	EBI-27129966	0.35
Q9Y3C1	Nucleolar protein 16 (HBV pre-S2 trans-regulated protein 3)	EBI-27129966	0.35
Q6DKI1	60S ribosomal protein L7-like 1 (Large ribosomal subunit protein uL30-like 1)	EBI-27129966	0.35
P22492	Histone H1t (Testicular H1 histone)	EBI-27129966	0.35
Q12788	Transducin beta-like protein 3 (WD repeat-containing protein SAZD)	EBI-27129966	0.35
Q9NWH9	SAFB-like transcription modulator (Modulator of estrogen-induced transcription)	EBI-27129966	0.35
P49841	Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)	EBI-27129966	0.35
Q9Y4C8	Probable RNA-binding protein 19 (RNA-binding motif protein 19)	EBI-27129966	0.35
P27448	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)	EBI-27129966	0.35
Q9H6R0	ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33)	EBI-27129966	0.35
Q3KQU3	MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1)	EBI-27129966	0.35
Q9UN81	LINE-1 retrotransposable element ORF1 protein (L1ORF1p) (LINE retrotransposable element 1) (LINE1 retrotransposable element 1)	EBI-27129966	0.35
Q14137	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein)	EBI-27129966	0.35
Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16)	EBI-27129966	0.35
Q9UNX4	WD repeat-containing protein 3	EBI-27129966	0.35
P38935	DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2)	EBI-27129966	0.35
O43663	Protein regulator of cytokinesis 1	EBI-27129966	0.35
Q659C4	La-related protein 1B (La ribonucleoprotein domain family member 1B) (La ribonucleoprotein domain family member 2) (La-related protein 2)	EBI-27129966	0.35
Q9NUD5	Zinc finger CCHC domain-containing protein 3	EBI-27129966	0.35
Q01780	Exosome component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)	EBI-27129966	0.35
P46783	40S ribosomal protein S10 (Small ribosomal subunit protein eS10)	EBI-27129966	0.35
O43660	Pleiotropic regulator 1	EBI-27129966	0.35
P46779	60S ribosomal protein L28 (Large ribosomal subunit protein eL28)	EBI-27129966	0.35
O60306	RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160)	EBI-27129966	0.35
Q13151	Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0)	EBI-27129966	0.35
P36873	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)	EBI-27129966	0.35
Q14692	Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog)	EBI-27129966	0.35
Q1KMD3	Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2)	EBI-27129966	0.35
Q14562	ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1)	EBI-27129966	0.35
Q99729	Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)	EBI-27129966	0.35
P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)	EBI-27129966	0.35
Q8N9T8	Protein KRI1 homolog	EBI-27129966	0.35
Q13601	KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1)	EBI-27129966	0.35
Q07666	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)	EBI-27129966	0.35
P07910	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)	EBI-27129966	0.35
P42766	60S ribosomal protein L35 (Large ribosomal subunit protein uL29)	EBI-27129966	0.35
Q07020	60S ribosomal protein L18 (Large ribosomal subunit protein eL18)	EBI-27129966	0.35
P62899	60S ribosomal protein L31 (Large ribosomal subunit protein eL31)	EBI-27129966	0.35
Q5SSJ5	Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74)	EBI-27129966	0.35
Q96E39	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	EBI-27129966	0.35
Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator) (Protein FAM120A)	EBI-27129966	0.35
Q13206	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10)	EBI-27129966	0.35
P10412	Histone H1.4 (Histone H1b) (Histone H1s-4)	EBI-27129966	0.35
P84103	Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)	EBI-27129966	0.35
Q92522	Histone H1.10 (Histone H1x)	EBI-27129966	0.35
P46013	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	EBI-27129966	0.35
P05455	Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)	EBI-27129966	0.35
P62280	40S ribosomal protein S11 (Small ribosomal subunit protein uS17)	EBI-27129966	0.35
P22087	rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin)	EBI-27129966	0.35
Q52LJ0	Protein FAM98B	EBI-27129966	0.35
P08708	40S ribosomal protein S17 (Small ribosomal subunit protein eS17)	EBI-27129966	0.35
O00567	Nucleolar protein 56 (Nucleolar protein 5A)	EBI-27129966	0.35
P78316	Nucleolar protein 14 (Nucleolar complex protein 14)	EBI-27129966	0.35
P16403	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	EBI-27129966	0.35
Q9H2U1	ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein)	EBI-27129966	0.35
P40429	60S ribosomal protein L13a (23 kDa highly basic protein) (Large ribosomal subunit protein uL13)	EBI-27129966	0.35
Q8TDD1	ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (ATP-dependent RNA helicase DP97) (DEAD box RNA helicase 97 kDa) (DEAD box protein 54)	EBI-27129966	0.35
Q9BQ39	ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2)	EBI-27129966	0.35
P38159	RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]	EBI-27129966	0.35
P26368	Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)	EBI-27129966	0.35
P62841	40S ribosomal protein S15 (RIG protein) (Small ribosomal subunit protein uS19)	EBI-27129966	0.35
P84098	60S ribosomal protein L19 (Large ribosomal subunit protein eL19)	EBI-27129966	0.35
P27635	60S ribosomal protein L10 (Laminin receptor homolog) (Large ribosomal subunit protein uL16) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM)	EBI-27129966	0.35
Q9UNX3	60S ribosomal protein L26-like 1 (Large ribosomal subunit protein uL24-like 1)	EBI-27129966	0.35
P62847	40S ribosomal protein S24 (Small ribosomal subunit protein eS24)	EBI-27129966	0.35
Q14684	Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)	EBI-27129966	0.35
P62244	40S ribosomal protein S15a (Small ribosomal subunit protein uS8)	EBI-27129966	0.35
Q9BZE4	GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1)	EBI-27129966	0.35
P61254	60S ribosomal protein L26 (Large ribosomal subunit protein uL24)	EBI-27129966	0.35
Q07955	Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)	EBI-27129966	0.35
P62277	40S ribosomal protein S13 (Small ribosomal subunit protein uS15)	EBI-27129966	0.35
Q6P158	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57)	EBI-27129966	0.35
P62241	40S ribosomal protein S8 (Small ribosomal subunit protein eS8)	EBI-27129966	0.35
O43390	Heterogeneous nuclear ribonucleoprotein R (hnRNP R)	EBI-27129966	0.35
P22626	Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)	EBI-27129966	0.35
P46781	40S ribosomal protein S9 (Small ribosomal subunit protein uS4)	EBI-27129966	0.35
O60506	Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)	EBI-27129966	0.35
P39023	60S ribosomal protein L3 (HIV-1 TAR RNA-binding protein B) (TARBP-B) (Large ribosomal subunit protein uL3)	EBI-27129966	0.35
P62750	60S ribosomal protein L23a (Large ribosomal subunit protein uL23)	EBI-27129966	0.35
P62753	40S ribosomal protein S6 (Phosphoprotein NP33) (Small ribosomal subunit protein eS6)	EBI-27129966	0.35
P18621	60S ribosomal protein L17 (60S ribosomal protein L23) (Large ribosomal subunit protein uL22) (PD-1)	EBI-27129966	0.35
Q9Y3I0	RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)	EBI-27129966	0.35
P15880	40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) (Small ribosomal subunit protein uS5)	EBI-27129966	0.35
P67809	Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)	EBI-27129966	0.35
P62701	40S ribosomal protein S4, X isoform (SCR10) (Single copy abundant mRNA protein) (Small ribosomal subunit protein eS4)	EBI-27129966	0.35
Q9NR30	Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)	EBI-27129966	0.35
Q00839	Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120)	EBI-27129966	0.35
Q08211	ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A)	EBI-27129966	0.35
Q92499	ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)	EBI-27129966	0.35
P61247	40S ribosomal protein S3a (Small ribosomal subunit protein eS1) (v-fos transformation effector protein) (Fte-1)	EBI-27129966	0.35
Q00987	E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)	EBI-30810851	0.40
Q96CW1	AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)	EBI-30812690	0.40

Cross-References

Database	Links
UNIPROT	P59595 Q7T3Z4 Q7TA14 Q7TF99 Q80E50
PDB	1SSK 1X7Q 2CJR 2GIB 2JW8 2OFZ 2OG3 3I6L 6IEX 7LG0
Pfam	PF00937
PROSITE	PS51929 PS51928

Nucleoprotein (Severe acute respiratory syndrome-related coronavirus)

General Information

Protein Information

Structure Viewer (PDB: 2JW8)

Subcellular Location

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Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

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Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (15 interactors)

Interactions with other proteins (240 interactors)

Cross-References

Database

Links

Description

Description