Synaptosomal-associated protein 25 - Homo sapiens

Synaptosomal-associated protein 25 (Homo sapiens)

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Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	Synaptosomal-associated protein 25
Accession Code	P60880
Gene	SNAP25
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 206)
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTD LGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNL RHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG

Structure Viewer (PDB: 3DDB)

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:P60879}. Cell membrane {By SimilarityUniProtKB:P60881}; Lipid-anchor {By SimilarityUniProtKB:P60879}. Synapse, synaptosome {By SimilarityUniProtKB:P60879}. Photoreceptor inner segment {By SimilarityUniProtKB:P60879}. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity). Colocalizes with PLCL1 at the cell membrane (By similarity). {By SimilarityUniProtKB:P60879, By SimilarityUniProtKB:P60881}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250\|UniProtKB:P60879}
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cytoplasm (GO:0005737) Cytoskeleton (GO:0005856) Cytosol (GO:0005829) Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane (GO:0031234) Glutamatergic Synapse (GO:0098978) Growth Cone (GO:0030426) Membrane (GO:0016020) Neuron Projection (GO:0043005) Perinuclear Region Of Cytoplasm (GO:0048471) Photoreceptor Inner Segment (GO:0001917) Plasma Membrane (GO:0005886) Postsynapse (GO:0098794) Presynaptic Membrane (GO:0042734) Ribbon Synapse (GO:0097470) SNARE Complex (GO:0031201) Somatodendritic Compartment (GO:0036477) Specific Granule Membrane (GO:0035579) Synaptic Vesicle (GO:0008021) Synaptobrevin 2-SNAP-25-Syntaxin-1a-Complexin I Complex (GO:0070032) Tertiary Granule Membrane (GO:0070821) Trans-Golgi Network (GO:0005802)

Biology & Function

Description
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. {By SimilarityUniProtKB:P60881}.
Assigned Ontology terms

Biological Process	Associative Learning (GO:0008306) Chemical Synaptic Transmission (GO:0007268) Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane (GO:0098967) Exocytosis (GO:0006887) Localization (GO:0051179) Locomotory Behavior (GO:0007626) Long-Term Synaptic Potentiation (GO:0060291) Neurotransmitter Receptor Internalization (GO:0099590) Neurotransmitter Uptake (GO:0001504) Regulation Of Insulin Secretion (GO:0050796) Regulation Of Neuron Projection Development (GO:0010975) Synaptic Vesicle Docking (GO:0016081) Synaptic Vesicle Exocytosis (GO:0016079) Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane (GO:0031629) Synaptic Vesicle Priming (GO:0016082) Vesicle Fusion (GO:0006906)
Molecular Function	Calcium-Dependent Protein Binding (GO:0048306) Lipid Binding (GO:0008289) Molecular Adaptor Activity (GO:0060090) SNAP Receptor Activity (GO:0005484) Syntaxin Binding (GO:0019905) Syntaxin-1 Binding (GO:0017075) Voltage-Gated Potassium Channel Activity (GO:0005249)

Disease associations

Description
Myasthenic syndrome, congenital, 18 (CMS18) [MIM:616330]: A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre- synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early- onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS18 is an autosomal dominant presynaptic disorder clinically characterized by early-onset muscle weakness and easy fatigability associated with delayed psychomotor development and ataxia. {Experimental EvidencePubMed:25381298}. Note=The disease is caused by variants affecting the gene represented in this entry.
Database Associations
OMIM	600322 616330
DisGeNET	6616

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (5 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P60880	Self	EBI-15937576	0.66
P00533	Epidermal growth factor receptor	EBI-4397510	0.55
P04406	Glyceraldehyde-3-phosphate dehydrogenase	EBI-26578093	0.35
Q15811	Intersectin-1	EBI-8589666	0.35
P0DTD1	2'-O-methyltransferase nsp16	EBI-26952878	0.56
Interactions with other proteins (58 interactors)

Partner (UniProt)		IntAct	Confidence score
Q8IUH5	Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17)	EBI-524783	0.49
Q16623	Syntaxin-1A (Neuron-specific antigen HPC-1)	EBI-26578093	0.55
O75558	Syntaxin-11	EBI-24362633	0.56
Q7Z6L0	Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)	EBI-735805	0.00
P63041	Complexin-1 (Complexin I) (CPX I) (Synaphin-2)	EBI-1032873	0.40
Q62668	Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)	EBI-1633551	0.35
A0A8I3MJW7	Biogenesis of lysosome-related organelles complex 1 subunit 7	EBI-1633551	0.35
Q9Y3C0	WASH complex subunit 3 (Coiled-coil domain-containing protein 53)	EBI-2350431	0.49
P42858	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-25947049	0.56
Q13360	Zinc finger protein 177	EBI-24670770	0.56
Q9BRT2	Ubiquinol-cytochrome-c reductase complex assembly factor 2 (Breast cancer-associated protein SGA-81M) (Mitochondrial nucleoid factor 1) (Mitochondrial protein M19)	EBI-24783513	0.56
Q8N4C7	Syntaxin-19	EBI-25157949	0.56
Q9UHK0	FMR1-interacting protein NUFIP1 (Nuclear FMR1-interacting protein 1) (Nuclear FMRP-interacting protein 1)	EBI-21549449	0.35
Q16854	Deoxyguanosine kinase, mitochondrial (EC 2.7.1.113) (Deoxyadenosine kinase, mitochondrial) (EC 2.7.1.76)	EBI-21603108	0.35
Q9NVR5	Protein kintoun (Dynein assembly factor 2, axonemal)	EBI-21603625	0.35
Q00496	Botulinum neurotoxin type E (BoNT/E) (Bontoxilysin-E) [Cleaved into: Botulinum neurotoxin E light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin E heavy chain (HC)]	EBI-15556226	0.44
P32851	Syntaxin-1A (Neuron-specific antigen HPC-1) (Synaptotagmin-associated 35 kDa protein) (P35A)	EBI-15937576	0.74
P61765	Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) (rbSec1)	EBI-15623390	0.40
P63045	Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)	EBI-15623390	0.40
O14810	Complexin-1 (Complexin I) (CPX I) (Synaphin-2)	EBI-15937521	0.73
P63027	Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)	EBI-15937576	0.76
P37840	Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)	EBI-21013481	0.50
O95183	Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)	EBI-21267749	0.35
P0DTC3	ORF3a protein (ORF3a) (Accessory protein 3a) (Protein 3a) (Protein U274) (Protein X1)	EBI-25686340	0.35
P0DTD8	ORF7b protein (ORF7b) (Accessory protein 7b)	EBI-25687199	0.35
Q7TFA1	Protein non-structural 7b (ns7b) (Accessory protein 7b)	EBI-25688644	0.35
P61278	Somatostatin (Growth hormone release-inhibiting factor) [Cleaved into: Somatostatin-28; Somatostatin-14 (SST-14); Neuronostatin (NST)]	EBI-26494704	0.35
Q9NRW1	Ras-related protein Rab-6B (EC 3.6.5.2)	EBI-26578093	0.35
Q13642	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1)	EBI-26578093	0.35
Q9UL88	Myosin-reactive immunoglobulin heavy chain variable region	EBI-26578093	0.35
Q9NP29	Microfibrillar protein 2	EBI-26578093	0.35
P05026	Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)	EBI-26578093	0.35
P06576	ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta)	EBI-26578093	0.35
Q59EP4	Mel transforming oncogene variant	EBI-26578093	0.35
P46821	Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]	EBI-26578093	0.35
P25705	ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha)	EBI-26578093	0.35
P62820	Ras-related protein Rab-1A (EC 3.6.5.2) (YPT1-related protein)	EBI-26578093	0.35
P60601	Imidazole glycerol phosphate synthase subunit HisH (EC 4.3.2.10) (IGP synthase glutaminase subunit) (EC 3.5.1.2) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH)	EBI-26578093	0.35
P84077	ADP-ribosylation factor 1 (EC 3.6.5.2)	EBI-26578093	0.51
P11142	Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)	EBI-26578093	0.35
P61421	V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1)	EBI-26578093	0.35
Q15904	V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)	EBI-26578093	0.35
Q9H313	Protein tweety homolog 1 (hTTY1)	EBI-26578093	0.35
P36542	ATP synthase subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit)	EBI-26578093	0.35
P20336	Ras-related protein Rab-3A	EBI-26578093	0.35
P55072	Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)	EBI-26578093	0.35
P17600	Synapsin-1 (Brain protein 4.1) (Synapsin I)	EBI-26578093	0.35
O95721	Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29)	EBI-26578093	0.35
P61764	Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)	EBI-26578093	0.53
P46459	Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF)	EBI-26578093	0.35
P23763	Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1)	EBI-26578093	0.35
Q6PUV4	Complexin-2 (Complexin II) (CPX II) (Synaphin-1)	EBI-26578093	0.35
Q86Y82	Syntaxin-12	EBI-26578093	0.35
O15400	Syntaxin-7	EBI-26578093	0.35
P21579	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)	EBI-26578093	0.35
P61266	Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2)	EBI-26578093	0.35
Q99719	Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1)	EBI-26578142	0.35
F1PAA9	Cadherin-1 (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	EBI-27079701	0.27

Cross-References

Database	Links
UNIPROT	P60880 B2RAU4 D3DW16 D3DW17 P13795 P36974 P70557 P70558 Q53EM2 Q5U0B5 Q8IXK3 Q96FM2 Q9BR45
PDB	1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH
Pfam	PF00835
PROSITE	PS50192
OMIM	600322 616330
DisGeNET	6616

Synaptosomal-associated protein 25 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 3DDB)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Disease associations

Description

Database Associations

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (5 interactors)

Interactions with other proteins (58 interactors)

Cross-References

Database

Links

Description

Description