Cdc42-interacting protein 4 - Homo sapiens

Cdc42-interacting protein 4 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Cdc42-interacting protein 4
Accession Code	Q15642
Gene	TRIP10
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 601)
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEV NDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQ DINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELE VVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKR WPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLAILSEISKSVKPRLASFRSLRGSRGTVVTEDFSHLPPEQQR KRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRG DSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTIS MAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTLN

Structure Viewer (PDB: 2KE4)

Subcellular Location

Description
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {By Similarity}. [Isoform 5]: Cytoplasm, perinuclear region.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cell Cortex (GO:0005938) Cell Projection (GO:0042995) Cytoplasm (GO:0005737) Cytoskeleton (GO:0005856) Cytosol (GO:0005829) Extracellular Exosome (GO:0070062) Golgi Apparatus (GO:0005794) Intracellular Membrane-Bounded Organelle (GO:0043231) Lysosome (GO:0005764) Nucleoplasm (GO:0005654) Perinuclear Region Of Cytoplasm (GO:0048471) Phagocytic Cup (GO:0001891)

Biology & Function

Description
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5- bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte- derived cells. May be required for the lysosomal retention of FASLG/FASL. {By Similarity, Experimental EvidencePubMed:11069762, Experimental EvidencePubMed:16318909, Experimental EvidencePubMed:16326391}.
Assigned Ontology terms

Biological Process	Actin Cytoskeleton Organization (GO:0030036) Cell Communication (GO:0007154) Endocytosis (GO:0006897) Signal Transduction (GO:0007165)
Molecular Function	Identical Protein Binding (GO:0042802) Lipid Binding (GO:0008289)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (3 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P07948	Tyrosine-protein kinase Lyn	EBI-8565817	0.51
Q14974	Importin subunit beta-1	EBI-30827298	0.44
Q15642	Self	EBI-1268134	0.74
Interactions with other proteins (55 interactors)

Partner (UniProt)		IntAct	Confidence score
P60953	Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)	EBI-7213336	0.61
Q9Y2W2	WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)	EBI-752548	0.37
Q96RU3	Formin-binding protein 1 (Formin-binding protein 17) (hFBP17)	EBI-1647547	0.27
P48023	Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]	EBI-7908855	0.59
A0A384KSJ5	Transcriptional regulator, GntR family	EBI-2817480	0.00
A0A5P8YEZ8	Ribosome-binding ATPase YchF	EBI-2873377	0.00
Q9Y4D1	Disheveled-associated activator of morphogenesis 1	EBI-6550032	0.52
Q9Z207	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (p134mDIA2) (mDIA2)	EBI-6550121	0.40
O08808	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (p140mDIA) (mDIA1)	EBI-6550199	0.40
O00401	Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)	EBI-24407610	0.56
Q8IUH5	Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17)	EBI-9090827	0.37
Q92558	Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)	EBI-10236688	0.56
Q17R89	Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2)	EBI-10238339	0.56
Q1RLN5	ARHGAP12 protein (Rho GTPase-activating protein 12)	EBI-10239195	0.56
Q68EM7	Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)	EBI-10249175	0.56
Q969G3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57)	EBI-10280647	0.56
Q9H4E5	Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein)	EBI-10306633	0.56
Q9Y3L3	SH3 domain-binding protein 1	EBI-10327866	0.56
P46379	Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)	EBI-11154173	0.35
Q6SPF0	Sterile alpha motif domain-containing protein 1 (SAM domain-containing protein 1) (Atherin)	EBI-11160311	0.35
P54274	Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)	EBI-11308271	0.37
Q9BSI4	TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2)	EBI-11308281	0.51
Q9NUX5	Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)	EBI-11308291	0.37
P53933	Phosphatidate phosphatase APP1 (PAP) (EC 3.1.3.4) (Actin patch protein 1)	EBI-11533915	0.56
O15156	Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK)	EBI-24294257	0.56
Q8IZP0	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)	EBI-24302596	0.56
P26367	Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin)	EBI-24333764	0.56
Q8IWW6	Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12)	EBI-24337375	0.56
P50221	Homeobox protein MOX-1 (Mesenchyme homeobox 1)	EBI-25244628	0.56
P42684	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)	EBI-25250506	0.56
Q13671	Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)	EBI-24484923	0.56
Q15428	Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)	EBI-24624817	0.56
O75564	Jerky protein homolog	EBI-24780027	0.56
Q6FHY5	MEOX2 protein	EBI-24376152	0.56
Q5T230	Undifferentiated embryonic cell transcription factor 1	EBI-24395781	0.56
Q9NVV9	THAP domain-containing protein 1	EBI-24455319	0.56
O43248	Homeobox protein Hox-C11 (Homeobox protein Hox-3H)	EBI-24560095	0.56
Q8N9I9	Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)	EBI-25196090	0.56
P52952	Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)	EBI-24792337	0.56
P81408	Protein ENTREP3 (Endosomal transmembrane epsin interactor 3) (Protein COTE1)	EBI-21535449	0.35
O15389	Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)	EBI-21881508	0.35
Q6UY01	Leucine-rich repeat-containing protein 31	EBI-21887518	0.40
Q6IN36	WAS/WASL-interacting protein family member 1 (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein)	EBI-16191410	0.35
Q5BJU7	Actin-binding protein WASF1 (Protein WAVE-1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)	EBI-16191410	0.35
P97573	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1)	EBI-16191410	0.50
E9PT20	Tyrosine-protein kinase (EC 2.7.10.2)	EBI-16191410	0.35
O08816	Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)	EBI-16191410	0.35
P39052	Dynamin-2 (EC 3.6.5.5)	EBI-16191410	0.35
P18484	AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)	EBI-16191410	0.35
P17096	High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R)	EBI-20935428	0.40
A2A935	Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)	EBI-21022882	0.35
P14404	Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein homolog)	EBI-21026252	0.35
P78325	Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a)	EBI-21225631	0.56
P42858	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-25944092	0.56
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)	EBI-26515065	0.37

Cross-References

Database	Links
UNIPROT	Q15642 B2R8A6 B7WP22 D6W645 O15184 Q53G22 Q5TZN1 Q6FI24 Q8NFL1 Q8TCY1 Q8TDX3 Q96RJ1
PDB	2CT4 2EFK 2KE4
Pfam	PF00611 PF00018
PROSITE	PS51741 PS51860 PS50002
OMIM	604504
DisGeNET	9322

Cdc42-interacting protein 4 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 2KE4)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (3 interactors)

Interactions with other proteins (55 interactors)

Cross-References

Database

Links

Description

Description