NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Cytoplasmic polyadenylation element-binding protein 4 - Homo sapiens - NucEnvDB

Cytoplasmic polyadenylation element-binding protein 4 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Cytoplasmic polyadenylation element-binding protein 4
Accession Code	Q17RY0
Gene	CPEB4
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 729)
MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKA KSQQQEQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTS SASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQ HHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRG LNGGITPLNSISPLKKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDT IKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLHSGLGSPHCFSHQNGERVERYSRKVFVGGLP PDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRP WNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAIS ARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDR PRHISFRWN

Structure Viewer (PDB: 2MKI)

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q7TN98}. Cell projection, dendrite {By SimilarityUniProtKB:Q7TN98}. Cell projection, dendritic spine {By SimilarityUniProtKB:Q7TN98}. Postsynaptic density {By SimilarityUniProtKB:Q7TN98}. Cell projection, axon {By SimilarityUniProtKB:Q7TN98}. Cell projection, growth cone {By SimilarityUniProtKB:Q7TN98}. Endoplasmic reticulum {By SimilarityUniProtKB:Q7TN98}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q7TN98}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cytoplasm (GO:0005737) Dendrite (GO:0030425) Dendritic Spine (GO:0043197) Endoplasmic Reticulum (GO:0005783) Growth Cone (GO:0030426) Messenger Ribonucleoprotein Complex (GO:1990124) Neuron Projection (GO:0043005) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Postsynaptic Density (GO:0014069) Synapse (GO:0045202)

Biology & Function

Description
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE- regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity). {By SimilarityUniProtKB:Q7TN98, Experimental EvidencePubMed:22138752, Experimental EvidencePubMed:24990967, Experimental EvidencePubMed:26398195, Experimental EvidencePubMed:27857118}.
Assigned Ontology terms

Biological Process	Cellular Response To Amino Acid Stimulus (GO:0071230) Cellular Response To Decreased Oxygen Levels (GO:0036294) Cellular Response To Glucose Starvation (GO:0042149) Ionotropic Glutamate Receptor Signaling Pathway (GO:0035235) Negative Regulation Of Cytoplasmic Translation (GO:2000766) Negative Regulation Of Neuron Apoptotic Process (GO:0043524) Response To Ischemia (GO:0002931)
Molecular Function	Metal Ion Binding (GO:0046872) MRNA 3'-UTR Binding (GO:0003730) MRNA Regulatory Element Binding Translation Repressor Activity (GO:0000900) Ribosome Binding (GO:0043022) RNA Binding (GO:0003723) Translation Factor Activity, RNA Binding (GO:0008135)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q17RY0	Self	EBI-11474906	0.40
Interactions with other proteins (8 interactors)

Partner (UniProt)		IntAct	Confidence score
Q8D052	ATP-binding protein Uup (EC 3.6.1.-)	EBI-2848200	0.00
P50616	Protein Tob1 (Transducer of erbB-2 1)	EBI-8596337	0.54
Q9H4B6	Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45)	EBI-8799416	0.27
Q9H6Z9	Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)	EBI-12503146	0.35
Q61474	RNA-binding protein Musashi homolog 1 (Musashi-1)	EBI-11474493	0.40
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)	EBI-11474918	0.40
Q6ZNJ1	Neurobeachin-like protein 2	EBI-16749633	0.35
P69479	Phosphoprotein (Protein P) (Protein M1)	EBI-25568044	0.35

Cross-References

Database	Links
UNIPROT	Q17RY0 B7ZLQ7 Q7Z310 Q8N405 Q9C0J0
PDB	2MKI 2MKJ 5DIF
Pfam	PF16366 PF16367
PROSITE	PS50102
OMIM	610607
DisGeNET	80315

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