NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Myotubularin-related protein 8 - Homo sapiens - NucEnvDB

Myotubularin-related protein 8 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Myotubularin-related protein 8
Accession Code	Q96EF0
Gene	MTMR8
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 704)
MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPITSLGCPLTLRCKNFRVA HFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICST YPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVD TRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIMDAG IFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFT QFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTM YGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQ HLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQVKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDM CTFEATGFSKDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ

Structure Viewer (PDB: 4Y7I)

Subcellular Location

Description
Nucleus envelope {Experimental EvidencePubMed:16787938}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nuclear Envelope (GO:0005635) Protein-Containing Complex (GO:0032991)

Biology & Function

Description
Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598). {Experimental EvidencePubMed:22647598, Experimental EvidencePubMed:26143924}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Autophagy (GO:0010507) Phosphatidylinositol Dephosphorylation (GO:0046856) Regulation Of Macroautophagy (GO:0016241)
Molecular Function	Phosphatidylinositol-3,5-Bisphosphate 3-Phosphatase Activity (GO:0052629) Phosphatidylinositol-3,5-Bisphosphate Phosphatase Activity (GO:0106018) Phosphatidylinositol-3-Phosphate Phosphatase Activity (GO:0004438)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q96QG7	Myotubularin-related protein 9	EBI-758404	0.81
Q6ZMQ8	Serine/threonine-protein kinase LMTK1	EBI-20980296	0.37
Interactions with other proteins (6 interactors)

Partner (UniProt)		IntAct	Confidence score
P20839	Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)	EBI-21610062	0.35
Q9Y216	Myotubularin-related protein 7 (Inositol 1,3-bisphosphate phosphatase) (EC 3.1.3.-) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)	EBI-21836819	0.35
Q969Q4	ADP-ribosylation factor-like protein 11 (ADP-ribosylation factor-like tumor suppressor protein 1)	EBI-21883664	0.35
P21860	Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)	EBI-20981036	0.37
Q9BUF5	Tubulin beta-6 chain (Tubulin beta class V)	EBI-27113652	0.35
Q8WXG6	MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)	EBI-27113652	0.35

Cross-References

Database	Links
UNIPROT	Q96EF0 Q5JT99 Q9NXP6
PDB	4Y7I
Pfam	PF06602
PROSITE	PS51339 PS00383
OMIM	301061
DisGeNET	55613

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