PRKCA-binding protein - Homo sapiens

PRKCA-binding protein (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	PRKCA-binding protein
Accession Code	Q9NRD5
Gene	PICK1
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 415)
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKG KTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTA ELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLN KAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKME LLDQKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPSRDTR GAAGPLDKGGSWCDS

Structure Viewer (PDB: 6BJO)

Subcellular Location

Description
Cytoplasm, perinuclear region. Membrane {By Similarity}; Peripheral membrane protein {By Similarity}. Membrane {By Similarity}; Lipid-anchor {By Similarity}. Postsynaptic density {By Similarity}. Synapse, synaptosome {By Similarity}. Cytoplasm, cytoskeleton {By Similarity}. Note=Also membrane-associated, present at excitatory synapses. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Cytoplasm (GO:0005737) Cytoskeleton (GO:0005856) Cytosol (GO:0005829) Endocytic Vesicle Membrane (GO:0030666) Golgi Apparatus (GO:0005794) Neuron Projection (GO:0043005) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Postsynaptic Density (GO:0014069) Postsynaptic Early Endosome (GO:0098842) Presynaptic Membrane (GO:0042734) Synapse (GO:0045202) Synaptic Vesicle (GO:0008021) Trans-Golgi Network Membrane (GO:0032588)

Biology & Function

Description
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {Experimental EvidencePubMed:20403402}.
Assigned Ontology terms

Biological Process	Cellular Response To Decreased Oxygen Levels (GO:0036294) Cellular Response To Glucose Starvation (GO:0042149) Dendritic Spine Maintenance (GO:0097062) Dendritic Spine Organization (GO:0097061) DNA Methylation Involved In Embryo Development (GO:0043045) DNA Methylation Involved In Gamete Generation (GO:0043046) Glial Cell Development (GO:0021782) Intracellular Protein Transport (GO:0006886) Long-Term Synaptic Depression (GO:0060292) Monoamine Transport (GO:0015844) Negative Regulation Of Arp2/3 Complex-Mediated Actin Nucleation (GO:0034316) Neuronal Ion Channel Clustering (GO:0045161) Positive Regulation Of Receptor Internalization (GO:0002092) Protein Kinase C-Activating G Protein-Coupled Receptor Signaling Pathway (GO:0007205) Protein Phosphorylation (GO:0006468) Receptor Clustering (GO:0043113) Regulation Of Arp2/3 Complex-Mediated Actin Nucleation (GO:0034315) Regulation Of Insulin Secretion (GO:0050796) Retrograde Vesicle-Mediated Transport, Golgi To Endoplasmic Reticulum (GO:0006890)
Molecular Function	Actin Filament Binding (GO:0051015) Arp2/3 Complex Binding (GO:0071933) Enzyme Binding (GO:0019899) G Protein-Coupled Receptor Binding (GO:0001664) Identical Protein Binding (GO:0042802) Membrane Curvature Sensor Activity (GO:0140090) Metal Ion Binding (GO:0046872) Phospholipid Binding (GO:0005543) Protein C-Terminus Binding (GO:0008022) Protein Domain Specific Binding (GO:0019904) Protein Kinase C Binding (GO:0005080) Signaling Receptor Binding (GO:0005102)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (15 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O75604	Ubiquitin carboxyl-terminal hydrolase 2	EBI-24275762	0.56
Q6ZRP7	Sulfhydryl oxidase 2	EBI-21519718	0.35
Q9BUZ4	TNF receptor-associated factor 4	EBI-24332833	0.56
Q9NRR5	Ubiquilin-4	EBI-950320	0.00
Q9WMX2	RNA-directed RNA polymerase	EBI-9081130	0.37
Q9NRD5	Self	EBI-24440238	0.56
Q06787	Fragile X messenger ribonucleoprotein 1	EBI-26509641	0.55
Q15056	Eukaryotic translation initiation factor 4H	EBI-24336001	0.56
Q92993	Histone acetyltransferase KAT5	EBI-24509305	0.56
P05129	Protein kinase C gamma type	EBI-953356	0.00
Q9Y6R4	Mitogen-activated protein kinase kinase kinase 4	EBI-21380388	0.00
Q13330	Metastasis-associated protein MTA1	EBI-24459255	0.56
Q9BVI4	Nucleolar complex protein 4 homolog	EBI-24505850	0.56
Q96CV9	Optineurin	EBI-24457528	0.56
Q8NC51	Plasminogen activator inhibitor 1 RNA-binding protein	EBI-24463602	0.56
Interactions with other proteins (381 interactors)

Partner (UniProt)		IntAct	Confidence score
Q16515	Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)	EBI-79148	0.51
P78348	Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)	EBI-79188	0.54
Q01959	Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)	EBI-7839657	0.54
P23975	Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) (Solute carrier family 6 member 2)	EBI-7839909	0.51
P31645	Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)	EBI-7840397	0.37
P49683	Prolactin-releasing peptide receptor (PrRP receptor) (PrRPR) (G-protein coupled receptor 10) (hGR3)	EBI-8009407	0.46
Q7Z2E3	Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)	EBI-950686	0.00
P54252	Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein)	EBI-952456	0.00
O15265	Ataxin-7 (Spinocerebellar ataxia type 7 protein)	EBI-952462	0.00
Q14CW9	Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog)	EBI-952498	0.00
Q96RK0	Protein capicua homolog	EBI-952534	0.00
P38432	Coilin (p80-coilin)	EBI-952630	0.00
Q16595	Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN)]	EBI-952768	0.00
Q99684	Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163)	EBI-952774	0.00
Q5VTD9	Zinc finger protein Gfi-1b (Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)	EBI-953050	0.00
Q9NZJ4	Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29)	EBI-953494	0.00
Q93009	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)	EBI-953614	0.00
Q3KSR8	Cytoplasmic envelopment protein 1	EBI-2622155	0.37
Q3KSS4	Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)	EBI-2623394	0.37
Q9NZN4	EH domain-containing protein 2 (PAST homolog 2)	EBI-3918707	0.37
P31749	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)	EBI-9063779	0.37
Q15223	Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111)	EBI-11668410	0.37
Q15911	Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)	EBI-24274297	0.56
Q8TAP4	LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)	EBI-24274829	0.56
Q96KN3	Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)	EBI-24275930	0.56
Q96ST8	Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123)	EBI-24276888	0.56
Q9UJX0	Oxidative stress-induced growth inhibitor 1 (Bone marrow stromal cell-derived growth inhibitor) (BMSC-derived growth inhibitor) (Ovary, kidney and liver protein 38) (huOKL38) (Pregnancy-induced growth inhibitor OKL38)	EBI-24278192	0.56
Q99633	Pre-mRNA-splicing factor 18 (PRP18 homolog) (hPRP18)	EBI-24278416	0.56
Q9BT17	Mitochondrial ribosome-associated GTPase 1 (GTP-binding protein 7) (Mitochondrial GTPase 1)	EBI-24278563	0.56
P49247	Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase)	EBI-24280459	0.56
Q9P2J8	Zinc finger protein 624	EBI-24280504	0.56
P07947	Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)	EBI-24281210	0.56
Q12774	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	EBI-24281059	0.56
Q86VK4	Zinc finger protein 410 (Another partner for ARF 1)	EBI-24281311	0.56
P55273	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)	EBI-24281941	0.56
O75771	DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)	EBI-24282267	0.56
Q7Z6G3	N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2)	EBI-24282418	0.56
P09661	U2 small nuclear ribonucleoprotein A' (U2 snRNP A')	EBI-24284868	0.56
Q6PF18	MORN repeat-containing protein 3	EBI-24285776	0.56
Q9BY14	Testis-expressed protein 101 (Cell surface receptor NYD-SP8) (Scleroderma-associated autoantigen) (Spermatogenesis-related gene protein)	EBI-24286791	0.56
P13682	Zinc finger protein 35 (Zinc finger protein HF.10)	EBI-24287175	0.56
Q56NI9	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)	EBI-24290604	0.56
O75031	Heat shock factor 2-binding protein	EBI-24291316	0.56
Q9H0A9	Speriolin-like protein (Spermatogenesis and centriole-associated protein 1-like protein)	EBI-24292384	0.56
Q7L273	BTB/POZ domain-containing protein KCTD9	EBI-24293130	0.56
Q8N554	Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477)	EBI-24294832	0.56
Q13043	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]	EBI-24295848	0.56
P61457	Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)	EBI-24296668	0.56
Q8IYH5	ZZ-type zinc finger-containing protein 3	EBI-24298036	0.56
Q6ZNH5	Zinc finger protein 497	EBI-24297929	0.56
P49910	Zinc finger protein 165 (Cancer/testis antigen 53) (CT53) (LD65) (Zinc finger and SCAN domain-containing protein 7)	EBI-24298635	0.56
Q8IW40	Coiled-coil domain-containing protein 103	EBI-24299060	0.56
Q9BYV2	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)	EBI-24300061	0.56
Q6NX45	Zinc finger protein 774	EBI-24301397	0.56
O95983	Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3)	EBI-24302986	0.56
Q9BPX1	17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1)	EBI-24303900	0.56
Q9ULW3	Activator of basal transcription 1 (hABT1) (Basal transcriptional activator)	EBI-24305866	0.56
Q5W5X9	Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8)	EBI-24305955	0.56
P43358	Melanoma-associated antigen 4 (Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen)	EBI-24307997	0.56
P42772	Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)	EBI-24308278	0.56
Q8WWY3	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31)	EBI-24308705	0.56
Q08117	TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)	EBI-24309537	0.56
Q7Z4V0	Zinc finger protein 438	EBI-24309655	0.56
Q9BSW7	Synaptotagmin-17 (Protein B/K) (Synaptotagmin XVII) (SytXVII)	EBI-24310347	0.56
Q13895	Bystin	EBI-24310949	0.56
Q9HC52	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	EBI-24311604	0.56
Q15772	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)	EBI-24312386	0.56
Q9C086	INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4)	EBI-24314142	0.56
Q8N6Y0	Harmonin-binding protein USHBP1 (AIE-75-binding protein) (Mutated in colon cancer protein 2) (MCC-2) (Usher syndrome type-1C protein-binding protein 1) (USH1C-binding protein 1)	EBI-24314498	0.56
Q9Y250	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)	EBI-24315716	0.56
Q96G04	Protein-lysine N-methyltransferase EEF2KMT (EC 2.1.1.-) (eEF2-lysine methyltransferase) (eEF2-KMT)	EBI-24317376	0.56
Q8N9N8	Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) (Haponin)	EBI-24317590	0.56
Q96H86	Zinc finger protein 764	EBI-24318883	0.56
P23025	DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)	EBI-24319146	0.56
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)	EBI-24323353	0.56
P61966	AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin)	EBI-24324433	0.56
Q9NX01	Thioredoxin-like protein 4B (Dim1-like protein)	EBI-24326050	0.56
Q9H1K1	Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein)	EBI-24326107	0.56
P32321	Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase)	EBI-24327302	0.56
Q7L5A3	Protein FAM214B	EBI-24329389	0.56
Q9UGP5	DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa)	EBI-24329540	0.56
Q5JST6	EF-hand domain-containing family member C2	EBI-24329690	0.56
Q9Y5B8	Nucleoside diphosphate kinase 7 (NDK 7) (NDP kinase 7) (EC 2.7.4.6) (nm23-H7)	EBI-24330141	0.56
Q96MY7	Protein FAM161B	EBI-24331110	0.56
Q9NQZ8	Endothelial zinc finger protein induced by tumor necrosis factor alpha (Zinc finger protein 71)	EBI-24332534	0.56
Q6ZN57	Zinc finger protein ZFP2 (Zfp-2) (Zinc finger protein 751)	EBI-24332969	0.56
Q68J44	Dual specificity phosphatase 29 (Dual specificity phosphatase 27) (Dual specificity phosphatase DUPD1) (EC 3.1.3.16, EC 3.1.3.48)	EBI-24333287	0.56
Q504U0	Renal cancer differentiation gene 1 protein	EBI-24333616	0.56
Q9HBT8	Zinc finger protein 286A	EBI-24334718	0.56
Q6P1J9	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	EBI-24334924	0.56
Q8N680	Zinc finger and BTB domain-containing protein 2	EBI-24336367	0.56
Q8TCE9	Placental protein 13-like (Charcot-Leyden crystal protein 2) (CLC2) (Galectin-14) (Gal-14)	EBI-24336562	0.56
Q8WYJ6	Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24)	EBI-24341060	0.56
A0A024R4Z4	HCG2039447, isoform CRA_d (HCG2042749, isoform CRA_c)	EBI-24342526	0.56
Q9HAN9	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1)	EBI-24343045	0.56
Q4VC12	Putative protein MSS51 homolog, mitochondrial (Zinc finger MYND domain-containing protein 17)	EBI-24344148	0.56
Q7LBR1	Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2)	EBI-24347130	0.56
Q86T90	Protein hinderin	EBI-24351146	0.56
Q5T6S3	PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)	EBI-24353562	0.56
Q92917	G-patch domain and KOW motifs-containing protein (G-patch domain-containing protein 5) (Protein MOS2 homolog) (Protein T54)	EBI-24353414	0.56
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)	EBI-24353678	0.56
Q9H147	Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1)	EBI-24359365	0.56
P40938	Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)	EBI-24360427	0.56
Q17RB8	LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191)	EBI-24360679	0.56
Q9BQP7	Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-)	EBI-24360919	0.56
Q96T60	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	EBI-24360963	0.56
Q9UJW9	SERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator)	EBI-24361138	0.56
Q96QA6	Protein yippee-like 2	EBI-24361956	0.56
P61086	Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)	EBI-24362532	0.56
Q969R5	Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)	EBI-24363925	0.56
P31751	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta)	EBI-25246907	0.56
Q16512	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)	EBI-25246962	0.56
P47897	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	EBI-25248117	0.56
Q3SY00	Testis-specific protein 10-interacting protein (Tsga10-interacting protein)	EBI-25249747	0.56
Q96MU7	YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)	EBI-25249902	0.56
Q9NSI2	Ribosome biogenesis protein SLX9 homolog	EBI-25249983	0.56
Q14119	Vascular endothelial zinc finger 1 (Putative transcription factor DB1) (Zinc finger protein 161)	EBI-25251633	0.56
Q9BV90	U11/U12 small nuclear ribonucleoprotein 25 kDa protein (U11/U12 snRNP 25 kDa protein) (U11/U12-25K) (Minus-99 protein)	EBI-25252778	0.56
Q9NQT4	Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B)	EBI-25253504	0.56
Q14451	Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)	EBI-25254111	0.56
Q8NEH6	Meiosis-specific nuclear structural protein 1	EBI-25254288	0.56
Q9BXS5	AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)	EBI-25254630	0.56
Q96MN5	Transcription elongation factor A N-terminal and central domain-containing protein 2	EBI-25254880	0.56
Q96HH0	ROBO3 protein	EBI-25255196	0.56
Q08AG9	Cytochrome P450, family 21, subfamily A, polypeptide 2	EBI-25256463	0.56
P08311	Cathepsin G (CG) (EC 3.4.21.20) [Cleaved into: Cathepsin G, C-terminal truncated form]	EBI-25256928	0.56
Q8IVS8	Glycerate kinase (EC 2.7.1.31) (HBeAg-binding protein 4)	EBI-25256884	0.56
Q969R2	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4)	EBI-25257560	0.56
Q9BZR8	Apoptosis facilitator Bcl-2-like protein 14 (Bcl2-L-14) (Apoptosis regulator Bcl-G)	EBI-25257945	0.56
Q96C55	Zinc finger protein 524	EBI-24364583	0.56
Q9BX10	GTP-binding protein 2	EBI-24365161	0.56
Q8NC69	BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6)	EBI-24366062	0.56
P57086	SCAN domain-containing protein 1	EBI-24366391	0.56
Q08426	Peroxisomal bifunctional enzyme (PBE) (PBFE) (L-bifunctional protein) (LBP) (Multifunctional enzyme 1) (MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]	EBI-24366679	0.56
P52564	Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)	EBI-24366773	0.56
O75400	Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)	EBI-24368824	0.56
P15622	Zinc finger protein 250 (Zinc finger protein 647)	EBI-24368717	0.56
Q9BU76	Multiple myeloma tumor-associated protein 2 (hMMTAG2)	EBI-24369460	0.56
Q9BUI4	DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62)	EBI-24478617	0.56
O75487	Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]	EBI-24478788	0.56
Q86YS7	C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa)	EBI-24479316	0.56
Q9HC98	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512)	EBI-24481182	0.56
Q15014	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX)	EBI-24482268	0.56
Q8TAU3	Zinc finger protein 417	EBI-24483381	0.56
P00540	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos)	EBI-24484736	0.56
P61289	Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)	EBI-24485685	0.56
O43296	Zinc finger protein 264	EBI-24486434	0.56
Q9H9D4	Zinc finger protein 408 (PR domain zinc finger protein 17)	EBI-24487140	0.56
O60437	Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)	EBI-24486864	0.56
P08579	U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')	EBI-24487243	0.56
P25786	Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)	EBI-24489535	0.56
Q8NHY3	GAS2-like protein 2 (GAS2-related protein on chromosome 17) (Growth arrest-specific protein 2-like 2)	EBI-24489781	0.56
Q6FHY5	MEOX2 protein	EBI-24490101	0.56
Q7L590	Protein MCM10 homolog (HsMCM10)	EBI-24491037	0.56
O75564	Jerky protein homolog	EBI-24492868	0.56
Q96MH2	Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)	EBI-24493184	0.56
Q6ZN18	Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2)	EBI-24493171	0.56
Q96GE4	Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45)	EBI-24496817	0.56
P26196	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)	EBI-24497555	0.56
Q96DX7	Tripartite motif-containing protein 44 (Protein DIPB)	EBI-24499846	0.56
Q29RF7	Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112)	EBI-24499780	0.56
Q9UJD0	Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3)	EBI-24502869	0.56
Q12905	Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)	EBI-24504771	0.56
Q969T4	Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)	EBI-24505369	0.56
Q9BTE7	DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)	EBI-24505977	0.56
Q02363	DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)	EBI-24512109	0.56
Q9BYU1	Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)	EBI-24516770	0.56
Q9NQ48	Leucine zipper transcription factor-like protein 1	EBI-24395147	0.56
Q9UII2	ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1)	EBI-24530813	0.56
Q8IZU1	Protein FAM9A	EBI-24607193	0.56
Q13322	Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)	EBI-24618876	0.56
O14613	Cdc42 effector protein 2 (Binder of Rho GTPases 1)	EBI-24622916	0.56
P17021	Zinc finger protein 17 (Zinc finger protein HPF3) (Zinc finger protein KOX10)	EBI-24369822	0.56
P25800	Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1)	EBI-24371855	0.56
Q9NUL5	Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN)	EBI-24372255	0.56
Q15041	ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum)	EBI-24372801	0.56
Q5VV52	Zinc finger protein 691	EBI-24373417	0.56
Q8IVW4	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine-protein kinase NKIAMRE)	EBI-24373579	0.56
P29084	Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2)	EBI-24374306	0.56
Q9UKT7	F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)	EBI-24376141	0.56
P67936	Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)	EBI-24377202	0.56
P30086	Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]	EBI-24377450	0.56
Q9P291	Armadillo repeat-containing X-linked protein 1 (ARM protein lost in epithelial cancers on chromosome X 1) (Protein ALEX1)	EBI-24377941	0.56
Q9UJV3	Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)	EBI-24378214	0.56
O15371	Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)	EBI-24378913	0.56
Q9NR46	Endophilin-B2 (SH3 domain-containing GRB2-like protein B2)	EBI-24379419	0.56
Q86YV0	RAS protein activator like-3	EBI-24379784	0.56
P08397	Porphobilinogen deaminase (PBG-D) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)	EBI-24380711	0.56
Q6IPR3	tRNA wybutosine-synthesizing protein 3 homolog (tRNA-yW-synthesizing protein 3) (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase)	EBI-24380890	0.56
Q719H9	BTB/POZ domain-containing protein KCTD1 (Potassium channel tetramerization domain-containing protein 1)	EBI-24381244	0.56
Q96LK0	Centrosomal protein of 19 kDa (Cep19)	EBI-24382692	0.56
Q9NU19	TBC1 domain family member 22B	EBI-24384246	0.56
O76064	E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)	EBI-24384325	0.56
Q86XF7	Zinc finger protein 575	EBI-24384959	0.56
Q92785	Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)	EBI-24386803	0.56
P51946	Cyclin-H (MO15-associated protein) (p34) (p37)	EBI-24387020	0.56
Q8IVT4	Hypothetical MGC50722	EBI-24388553	0.56
Q9BV20	Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein)	EBI-24389069	0.56
Q8IYX8	Centrosomal protein CEP57L1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa-related protein) (Cep57R) (Cep57-related protein)	EBI-24389157	0.56
Q6NT76	Homeobox-containing protein 1 (Homeobox telomere-binding protein 1) (Telomere-associated homeobox-containing protein 1)	EBI-24389102	0.56
Q8TBE0	Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1)	EBI-24389462	0.56
P63241	Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)	EBI-24390128	0.56
Q15102	Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)	EBI-24390311	0.56
Q5MJ10	Sperm protein associated with the nucleus on the X chromosome N2 (Nuclear-associated protein SPAN-Xn2) (SPANX-N2) (SPANX family member N2)	EBI-24391549	0.56
Q2TBE0	CWF19-like protein 2	EBI-24392096	0.56
Q9GZM8	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)	EBI-24393020	0.56
Q5T7W7	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 (Rhodanese domain-containing protein 2)	EBI-24394814	0.56
Q9BPY8	Homeodomain-only protein (Lung cancer-associated Y protein) (Not expressed in choriocarcinoma protein 1) (Odd homeobox protein 1)	EBI-24394561	0.56
O43167	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450)	EBI-24395737	0.56
Q9H7E9	UPF0488 protein C8orf33	EBI-24396085	0.56
Q6ZSB9	Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509)	EBI-24396546	0.56
O15078	Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2)	EBI-24396419	0.56
Q96GM5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit)	EBI-24397745	0.56
Q9NTM9	Copper homeostasis protein cutC homolog	EBI-24398287	0.56
O43159	Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin)	EBI-24399822	0.56
Q9NW75	G patch domain-containing protein 2	EBI-24400845	0.67
Q6IQ23	Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)	EBI-24401489	0.56
Q49AN0	Cryptochrome-2	EBI-24401410	0.56
Q9UPY8	Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3)	EBI-24401669	0.56
P45984	Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)	EBI-24403198	0.56
Q13214	Semaphorin-3B (Sema A(V)) (Semaphorin-V) (Sema V)	EBI-24403974	0.56
Q70IA8	MOB kinase activator 3C (Mob1 homolog 2C) (Mps one binder kinase activator-like 2C)	EBI-24404275	0.56
Q86YD7	Protein FAM90A1	EBI-24404691	0.56
O60941	Dystrobrevin beta (DTN-B) (Beta-dystrobrevin)	EBI-24405462	0.56
Q15631	Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO)	EBI-24406696	0.56
Q8TBB0	THAP domain-containing protein 6	EBI-24407185	0.56
Q92551	Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1)	EBI-24408028	0.56
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]	EBI-24408787	0.56
Q9H257	Caspase recruitment domain-containing protein 9 (hCARD9)	EBI-24409408	0.56
Q96IQ9	Zinc finger protein 414	EBI-24411745	0.56
Q04864	Proto-oncogene c-Rel	EBI-24413327	0.56
Q96CD0	F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8)	EBI-24413904	0.56
Q68D86	Coiled-coil domain-containing protein 102B	EBI-24413834	0.56
Q96GN5	Cell division cycle-associated 7-like protein (Protein JPO2) (Transcription factor RAM2)	EBI-24414466	0.56
P28702	Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)	EBI-24414850	0.56
P56524	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-24415246	0.56
Q9H788	SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)	EBI-24415751	0.56
P19784	Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)	EBI-24416093	0.56
O95696	Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2)	EBI-25260284	0.56
P26367	Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin)	EBI-25260785	0.56
P59910	DnaJ homolog subfamily B member 13 (Testis and spermatogenesis cell-related protein 6) (Testis spermatocyte apoptosis-related gene 6 protein) (Testis spermatogenesis apoptosis-related gene 3 protein) (Testis spermatogenesis apoptosis-related gene 6 protein)	EBI-25260844	0.56
O96006	E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)	EBI-25261606	0.56
Q96FN4	Copine-2 (Copine II)	EBI-25261540	0.56
O14530	Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation) (Protein 1-4)	EBI-25262634	0.56
Q3MJ62	Zinc finger and SCAN domain-containing protein 23 (Zinc finger protein 390) (Zinc finger protein 453)	EBI-25263054	0.56
Q8N8B7	Transcription elongation factor A N-terminal and central domain-containing protein (TFIIS central domain-containing protein 1)	EBI-25263780	0.56
Q13541	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	EBI-24416710	0.56
Q3B820	Protein FAM161A	EBI-24416662	0.56
O43320	Fibroblast growth factor 16 (FGF-16)	EBI-24417591	0.56
Q8N6N6	Protein NATD1 (N-acetyltransferase domain-containing protein 1)	EBI-24418647	0.56
Q9UBB9	Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1)	EBI-24420579	0.56
Q9BWG6	Sodium channel modifier 1	EBI-24422624	0.56
Q9UHV2	SERTA domain-containing protein 1 (CDK4-binding protein p34SEI1) (SEI-1) (p34(SEI-1)) (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1)	EBI-24422762	0.56
Q9GZT3	SRA stem-loop-interacting RNA-binding protein, mitochondrial	EBI-24423161	0.56
Q9NR81	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN)	EBI-24423597	0.56
Q96NC0	Zinc finger matrin-type protein 2	EBI-24425015	0.56
Q9HBH7	Protein BEX1 (Brain-expressed X-linked protein 1)	EBI-24425308	0.56
Q53S33	BolA-like protein 3	EBI-24425720	0.56
O75344	Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36)	EBI-24425856	0.56
Q8TAE8	Growth arrest and DNA damage-inducible proteins-interacting protein 1 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Mitochondrial large ribosomal subunit protein mL64) (Papillomavirus L2-interacting nuclear protein 1) (PLINP) (PLINP-1) (p53-responsive gene 6 protein)	EBI-24426925	0.56
O15481	Melanoma-associated antigen B4 (MAGE-B4 antigen)	EBI-24428439	0.56
Q9H609	Zinc finger protein 576	EBI-24428748	0.56
O00463	TNF receptor-associated factor 5 (RING finger protein 84)	EBI-24430288	0.56
P11532	Dystrophin	EBI-24430507	0.56
O00488	Zinc finger protein 593 (Zinc finger protein T86)	EBI-24430913	0.56
Q9NQZ2	Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog)	EBI-24431310	0.56
A8MXD5	Glutaredoxin domain-containing cysteine-rich protein 1	EBI-24431411	0.56
P41223	Protein BUD31 homolog (Protein EDG-2) (Protein G10 homolog)	EBI-24432260	0.56
Q9UFW8	CGG triplet repeat-binding protein 1 (CGG-binding protein 1) (20 kDa CGG-binding protein) (p20-CGGBP DNA-binding protein)	EBI-24432238	0.56
Q8N954	G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75)	EBI-24432937	0.56
Q4G0R1	PIBF1 protein	EBI-24434657	0.56
P19544	Wilms tumor protein (WT33)	EBI-24435564	0.56
P38919	Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]	EBI-24435989	0.56
P51451	Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)	EBI-24437371	0.56
Q9NRX1	RNA-binding protein PNO1 (Partner of NOB1)	EBI-24437947	0.56
Q8NBZ0	INO80 complex subunit E (Coiled-coil domain-containing protein 95)	EBI-24438358	0.56
Q8NHQ9	ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55)	EBI-24438211	0.56
Q96JC9	ELL-associated factor 1	EBI-24439310	0.56
Q5XKK7	Protein FAM219B	EBI-24439630	0.56
P56270	Myc-associated zinc finger protein (MAZI) (Pur-1) (Purine-binding transcription factor) (Serum amyloid A-activating factor-1) (SAF-1) (Transcription factor Zif87) (ZF87) (Zinc finger protein 801)	EBI-24440260	0.56
Q9HAT0	Ropporin-1A (Cancer/testis antigen 91) (CT91) (Rhophilin-associated protein 1A)	EBI-24441340	0.56
O43805	Microtubule nucleation factor SSNA1 (Nuclear autoantigen of 14 kDa) (Sjoegren syndrome nuclear autoantigen 1)	EBI-24442839	0.56
Q9NP66	High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)	EBI-24443445	0.56
Q13573	SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)	EBI-24446534	0.56
Q9BRG1	Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25)	EBI-24447109	0.56
B7ZLI8	Serine/threonine kinase 19 (Serine/threonine-protein kinase 19)	EBI-24447554	0.56
Q13671	Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)	EBI-24447914	0.56
Q96HR9	Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1)	EBI-24448669	0.56
Q14919	Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha)	EBI-24449156	0.56
Q9BUL9	Ribonuclease P protein subunit p25 (RNase P protein subunit p25)	EBI-24450780	0.56
Q9P0N9	TBC1 domain family member 7 (Cell migration-inducing protein 23)	EBI-24450912	0.56
Q9H0I2	Enkurin domain-containing protein 1	EBI-24451265	0.56
Q9Y530	ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-)	EBI-24452827	0.56
Q15560	Transcription elongation factor A protein 2 (Testis-specific S-II) (Transcription elongation factor S-II protein 2) (Transcription elongation factor TFIIS.l)	EBI-24454204	0.56
Q03933	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2)	EBI-24456616	0.56
Q7L775	EPM2A-interacting protein 1 (Laforin-interacting protein)	EBI-24460252	0.56
Q5SQQ9	Ventral anterior homeobox 1	EBI-24460787	0.56
Q9Y3S2	Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein)	EBI-24462021	0.56
Q6UWP7	Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (1-acylglycerol-3-phosphate O-acyltransferase 8) (1-AGP acyltransferase 8) (1-AGPAT 8) (EC 2.3.1.51) (Acyl-CoA:lysocardiolipin acyltransferase 1)	EBI-24461920	0.56
P48775	Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)	EBI-24463913	0.56
Q14565	Meiotic recombination protein DMC1/LIM15 homolog	EBI-24463865	0.56
P20719	Homeobox protein Hox-A5 (Homeobox protein Hox-1C)	EBI-24464716	0.56
Q9BT49	THAP domain-containing protein 7	EBI-24465323	0.56
Q86UD4	Zinc finger protein 329	EBI-24465290	0.56
Q8IXL7	Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14)	EBI-24466095	0.56
O14737	Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19)	EBI-24467314	0.56
Q5JTD7	Leucine-rich repeat-containing protein 73	EBI-24468020	0.56
O95201	Zinc finger protein 205 (Zinc finger protein 210)	EBI-24469813	0.56
Q9Y5A6	Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38)	EBI-24470493	0.56
Q4VC44	FLYWCH-type zinc finger-containing protein 1	EBI-24470388	0.56
Q15735	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase J)	EBI-24470900	0.56
Q9UBU8	Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Protein MSL3-1) (Transcription factor-like protein MRG15)	EBI-24471970	0.56
Q8IZ69	tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-)	EBI-24473683	0.56
Q15287	RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)	EBI-24473661	0.56
Q8IYA8	Interactor of HORMAD1 protein 1 (Cancer/testis antigen 74) (CT74) (Coiled-coil domain-containing protein 36)	EBI-24475631	0.56
Q9H1K6	Talin rod domain-containing protein 1 (Mesoderm development candidate 1)	EBI-24476134	0.56
Q9UBL6	Copine-7 (Copine VII)	EBI-24477247	0.56
Q86Y79	Probable peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)	EBI-24477236	0.56
P80188	Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25)	EBI-24533066	0.56
Q6QNY1	Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) (Centrosome-associated protein)	EBI-24535192	0.56
P48443	Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)	EBI-24539056	0.56
O14519	Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor)	EBI-24546970	0.56
Q9H0C1	Zinc finger MYND domain-containing protein 12	EBI-24564635	0.56
Q5T686	Arginine vasopressin-induced protein 1 (AVP-induced protein 1)	EBI-24574195	0.56
Q8N7C3	Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2)	EBI-24578447	0.56
Q6PF05	Tetratricopeptide repeat protein 23-like	EBI-24582383	0.56
Q96BT7	Alkylated DNA repair protein alkB homolog 8 (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.229)	EBI-24593875	0.56
Q6NTE8	MRN complex-interacting protein (MRN-interacting protein)	EBI-24637325	0.56
P16444	Dipeptidase 1 (EC 3.4.13.19) (Beta-lactamase) (EC 3.5.2.6) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP)	EBI-21514808	0.35
Q92692	Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)	EBI-21519718	0.35
Q13563	Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)	EBI-21519718	0.35
P52799	Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L)	EBI-21519718	0.35
Q9Y697	Cysteine desulfurase, mitochondrial (EC 2.8.1.7)	EBI-21519718	0.35
Q9Y624	Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)	EBI-21519718	0.35
Q9Y613	FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1)	EBI-21519718	0.35
Q9UL01	Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2)	EBI-21519718	0.35
Q9UGV2	Protein NDRG3 (N-myc downstream-regulated gene 3 protein)	EBI-21519718	0.35
Q9NVR0	Kelch-like protein 11	EBI-21519718	0.35
Q9NQY0	Bridging integrator 3	EBI-21519718	0.35
Q9C073	Protein FAM117A (C/EBP-induced protein)	EBI-21519718	0.35
Q9BZF9	Uveal autoantigen with coiled-coil domains and ankyrin repeats	EBI-21519718	0.55
Q8NDH6	Islet cell autoantigen 1-like protein (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein)	EBI-21519718	0.35
Q86WK6	Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2)	EBI-21519718	0.35
Q86U70	LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)	EBI-21519718	0.35
Q7RTV5	Peroxiredoxin-like 2C (AhpC/TSA antioxidant enzyme domain-containing protein 1) (Thioredoxin-like protein AAED1)	EBI-21519718	0.35
Q3T906	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein GNPTAB) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta]	EBI-21519718	0.35
Q15904	V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)	EBI-21519718	0.35
Q15375	Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11)	EBI-21519718	0.35
Q05084	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69)	EBI-21519718	0.35
P98196	Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A)	EBI-21519718	0.35
P98172	Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]	EBI-21519718	0.35
P53367	Arfaptin-1 (ADP-ribosylation factor-interacting protein 1)	EBI-21519718	0.35
P23229	Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]	EBI-21519718	0.35
P17028	Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17)	EBI-21519718	0.35
A1L0T0	2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein)	EBI-21519718	0.35
Q02833	Ras association domain-containing protein 7 (HRAS1-related cluster protein 1)	EBI-21525884	0.35
Q8TDR4	T-complex protein 10A homolog 1 (T-complex protein 10A-1) (TCP10A-1) (TCP10-like)	EBI-21617027	0.35
P43355	Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)	EBI-21634905	0.35
O75787	Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]	EBI-21856696	0.35
Q92844	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	EBI-20737201	0.35
Q99996	A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao)	EBI-21369499	0.00
P07196	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	EBI-21380808	0.00
P08621	U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)	EBI-21387006	0.00
Q01082	Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)	EBI-21387372	0.00
P82094	TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa)	EBI-21387842	0.00
B5ME19	Eukaryotic translation initiation factor 3 subunit C-like protein	EBI-21388090	0.00
Q8TDR0	TRAF3-interacting protein 1 (Interleukin-13 receptor alpha 1-binding protein 1) (Intraflagellar transport protein 54 homolog) (Microtubule-interacting protein associated with TRAF3) (MIP-T3)	EBI-21392320	0.00
P42858	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-25962458	0.56
Q96QS3	Homeobox protein ARX (Aristaless-related homeobox)	EBI-26508337	0.51
P26358	DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)	EBI-26508381	0.51
Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)	EBI-26508359	0.51
P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)	EBI-26508587	0.51
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)	EBI-26508663	0.51
P49815	Tuberin (Tuberous sclerosis 2 protein)	EBI-26508755	0.51
Q92574	Hamartin (Tuberous sclerosis 1 protein)	EBI-26508735	0.51
P51531	Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)	EBI-26508695	0.51
P78352	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	EBI-26509348	0.37
P51116	RNA-binding protein FXR2 (FMR1 autosomal homolog 2)	EBI-26512077	0.37
Q9NZ94	Neuroligin-3 (Gliotactin homolog)	EBI-26513344	0.37
Q7TLC7	Uncharacterized protein 14	EBI-26377368	0.35
P35226	Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)	EBI-27108918	0.35

Cross-References

Database	Links
UNIPROT	Q9NRD5 B3KS52 O95906
PDB	2GZV 6AR4 6BJN 6BJO
Pfam	PF06456 PF00595
PROSITE	PS50870 PS50106
OMIM	605926
DisGeNET	9463

PRKCA-binding protein (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 6BJO)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (15 interactors)

Interactions with other proteins (381 interactors)

Cross-References

Database

Links

Description

Description