NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Protein simr-1 - Caenorhabditis elegans - NucEnvDB

Protein simr-1 (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Protein simr-1
Accession Code	O01477
Gene	simr
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 691)
MSNEKQQWDDAYCLAEEMHDAGRPFKREELNIADQFICSRFSTIFEYDPYKDTYGFRNQELTHAIPVKSKCRHISDVDILELKKNTANADIRFPSYLNICPVYAMHPFTVLAFDLSKPVPMGMNASMENA APNMKSPTEAEITPGTIYIFKHRDNKCYRCVILFEDGDNNVSDADRKYMVAFLDTPQVVSVKLKTLFHLGKFTIESYPCALYCCRAVGILEIRKDFGADLNGQINEFYKDKVKRKSGVHALIYKKDDRGD KLIFDCPSILGTSMTMALEIKDVIGHRSVAENDPTALSYDELVSKQLPTVDIDDHNSSVVLDLEESVIAQELGSTNGADCPCNNDNIDDFMQSQRQNPLDNNRDNWDRINESRSSMQSFAINQSQAITAN PTPQPTFDESSGEVQTIPESINNLALNGRYLEDGRGTEEIREERSVESRQIGNQVVSQASCNYLEARQNSTQTANAESVCAIISESHAALPTDIQVIPSQHVLNENNHTVLPSVAPIIRNATGHSHIFGR QIPSPAFRRESLSSGNSIQVATFAATTGPCGSNTSRPTAQNTANSSINQDMSISNSSTNARLITIAQDNLNDTENWPNSEREQSATEMESGAEATTNSAVDEFAQVSDDMKGLADSMINFLRLTANSNNQ DAFKANIFAMELISTKIPNQLTKRFFTLKIAEAKSLAEGFN

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:32338603}. Note=Localizes to perinuclear foci in germ cells, called SIMR foci, which are distinct from Mutator foci, P granules and Z granules (PubMed:32338603). SIMR foci are stacked, with znfx-1 localizing between simr-1 and pgl-1 (PubMed:32338603). Its localization at SIMR foci is adjacent to the mutator complex protein mut-16 (PubMed:32338603). Perinuclear localization is not dependent on mut-16 (PubMed:32338603). {Experimental EvidencePubMed:32338603}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Acts downstream of piRNA production to promote mediator complex-dependent endogenous siRNA biogenesis from piRNA-target mRNAs in the RNA interference pathway in germ cells (PubMed:32338603). Not required to identify target mRNA by the piRNA pathway (PubMed:32338603). Plays a role in both spermatogenesis and oogenesis and in maintaining fertility over multiple generations, probably by directing mutator-dependent silencing to piRNA-targeted genes (PubMed:32338603). {Experimental EvidencePubMed:32338603}.
Assigned Ontology terms

Biological Process	Positive Regulation Of Brood Size (GO:0090727) Positive Regulation Of Oogenesis (GO:1905881) SiRNA Processing (GO:0030422) Spermatogenesis (GO:0007283)
Molecular Function

Cross-References

Database	Links
UNIPROT	O01477

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