Serine/threonine-protein kinase 16 - Homo sapiens

Serine/threonine-protein kinase 16 (Homo sapiens)

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Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Serine/threonine-protein kinase 16
Accession Code	O75716
Gene	STK16
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 305)
MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRL VAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEG QPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQ KGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQHTTQI

Structure Viewer (PDB: 2BUJ)

Subcellular Location

Description
Cytoplasm, perinuclear region. Membrane {By Similarity}; Lipid-anchor {By Similarity}. Note=Associates with Golgi and Golgi-derived vesicles. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	Curator Inference {ECO:0000305\|PubMed:10364453}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Golgi Apparatus (GO:0005794) Golgi-Associated Vesicle (GO:0005798) Nucleoplasm (GO:0005654) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {Experimental EvidencePubMed:10364453}.
Assigned Ontology terms

Biological Process	Cellular Response To Transforming Growth Factor Beta Stimulus (GO:0071560) Positive Regulation Of Transcription By RNA Polymerase II (GO:0045944) Protein Autophosphorylation (GO:0046777)
Molecular Function	ATP Binding (GO:0005524) Non-Membrane Spanning Protein Tyrosine Kinase Activity (GO:0004715) Protein Serine Kinase Activity (GO:0106310) Protein Serine/Threonine Kinase Activity (GO:0004674) RNA Polymerase II Cis-Regulatory Region Sequence-Specific DNA Binding (GO:0000978)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (3 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q13137	Calcium-binding and coiled-coil domain-containing protein 2	EBI-10189253	0.56
Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	EBI-28931389	0.35
O15162	Phospholipid scramblase 1	EBI-10189073	0.56
Interactions with other proteins (110 interactors)

Partner (UniProt)		IntAct	Confidence score
P49247	Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase)	EBI-757201	0.67
Q8N5Z5	BTB/POZ domain-containing protein KCTD17	EBI-757423	0.78
Q6UY14	ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1)	EBI-757837	0.62
Q15583	Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)	EBI-1060072	0.00
Q05084	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69)	EBI-1061392	0.00
Q9NRH2	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)	EBI-1063140	0.00
O75116	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)	EBI-1066240	0.00
P26441	Ciliary neurotrophic factor (CNTF)	EBI-1066319	0.00
Q96RG2	PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)	EBI-1067304	0.00
P63162	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein)	EBI-1070450	0.00
Q93063	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2) (Putative tumor suppressor protein EXT2)	EBI-1070470	0.00
P41235	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)	EBI-1071104	0.00
P40337	von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)	EBI-1074035	0.00
Q9HB66	Alternative protein MKKS (McKusick-Kaufman syndrome, isoform CRA_a) (Molecular chaperone MKKS) (PNAS-117)	EBI-1075221	0.00
Q14680	Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)	EBI-1078077	0.00
Q14164	Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)	EBI-1078621	0.00
Q6P2I7	Endogenous Bornavirus-like nucleoprotein 2 (Endogenous Borna-like N element-2) (EBLN-2)	EBI-1084989	0.00
Q8N5R6	Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61)	EBI-8639058	0.37
P67870	Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)	EBI-7136780	0.37
Q8IWZ5	Tripartite motif-containing protein 42	EBI-10189041	0.72
P50222	Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2)	EBI-10189051	0.56
Q8IYX7	Stabilizer of axonemal microtubules 1	EBI-10189061	0.72
O43186	Cone-rod homeobox protein	EBI-10189085	0.56
O43597	Protein sprouty homolog 2 (Spry-2)	EBI-10189095	0.56
O43734	E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)	EBI-10189107	0.56
O95967	EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)	EBI-10189117	0.72
P12757	Ski-like protein (Ski-related oncogene) (Ski-related protein)	EBI-10189127	0.56
P14373	Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (RING-type E3 ubiquitin transferase TRIM27) (Ret finger protein) (Tripartite motif-containing protein 27)	EBI-10189139	0.56
P15884	Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)	EBI-10189151	0.56
P60370	Keratin-associated protein 10-5 (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5)	EBI-10189177	0.56
P60409	Keratin-associated protein 10-7 (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7)	EBI-10189187	0.56
P60410	Keratin-associated protein 10-8 (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8)	EBI-10189197	0.72
P60411	Keratin-associated protein 10-9 (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9)	EBI-10189209	0.56
Q04864	Proto-oncogene c-Rel	EBI-10189221	0.56
Q08117	TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)	EBI-10189231	0.56
Q0VD86	Protein INCA1 (Inhibitor of CDK interacting with cyclin A1)	EBI-10189241	0.72
Q13829	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial)	EBI-10189263	0.56
Q15654	Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1)	EBI-10189275	0.56
Q5JR59	Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa)	EBI-10189289	0.56
Q5JST6	EF-hand domain-containing family member C2	EBI-10189301	0.56
Q5JXC2	Migration and invasion-inhibitory protein (IGFBP2-binding protein) (Invasion-inhibitory protein 45) (IIp45)	EBI-10189313	0.67
Q6PEX3	Keratin-associated protein 26-1	EBI-10189325	0.56
Q7Z3S9	Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)	EBI-10189344	0.56
Q8HWS3	DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1)	EBI-10189356	0.56
Q92824	Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)	EBI-10189400	0.56
Q96EY1	DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)	EBI-10189410	0.56
Q96Q35	Flagellum-associated coiled-coil domain-containing protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein)	EBI-10189422	0.56
Q99081	Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)	EBI-10189434	0.56
Q9BQ13	BTB/POZ domain-containing protein KCTD14	EBI-10189446	0.67
Q9GZT8	NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein)	EBI-10189463	0.56
Q9NRY6	Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)	EBI-10189475	0.72
Q9UKT9	Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)	EBI-10189487	0.56
Q9Y295	Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-)	EBI-10325852	0.56
Q8XC86	EspB (T3SS translocator EspB)	EBI-10038684	0.37
Q7DB77	Translocated intimin receptor Tir (Secreted effector protein Tir)	EBI-10039518	0.51
B7UM99	Translocated intimin receptor Tir (Secreted effector protein Tir)	EBI-10040304	0.37
Q13185	Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)	EBI-24281792	0.56
A8MQ03	Cysteine-rich tail protein 1	EBI-24308246	0.56
P0DPK4	Notch homolog 2 N-terminal-like protein C	EBI-24330984	0.56
Q7Z3K6	Mesoderm induction early response protein 3 (Mi-er3)	EBI-24336466	0.56
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54)	EBI-24353346	0.56
Q9NQX0	Putative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6)	EBI-24363537	0.56
Q8IUG1	Keratin-associated protein 1-3 (Keratin-associated protein 1.8) (Keratin-associated protein 1.9)	EBI-25258808	0.56
Q96KN3	Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)	EBI-25259197	0.56
Q9Y3S2	Zinc finger protein 330 (Nucleolar autoantigen 36) (Nucleolar cysteine-rich protein)	EBI-24486018	0.56
P51114	RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p)	EBI-24486544	0.56
P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	EBI-24491334	0.56
O95994	Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)	EBI-24509792	0.56
Q2I0M5	R-spondin-4 (Roof plate-specific spondin-4) (hRspo4)	EBI-24516412	0.56
O15496	Group 10 secretory phospholipase A2 (EC 3.1.1.4) (Group X secretory phospholipase A2) (GX sPLA2) (sPLA2-X) (Phosphatidylcholine 2-acylhydrolase 10)	EBI-24522989	0.56
Q96D03	DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)	EBI-24524948	0.56
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1)	EBI-24529669	0.56
A8MUP2	Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CS-KMT) (EC 2.1.1.-) (Methyltransferase-like protein 12, mitochondrial)	EBI-24619225	0.56
Q03431	Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)	EBI-24625735	0.56
Q8IUC1	Keratin-associated protein 11-1 (High sulfur keratin-associated protein 11.1)	EBI-24630962	0.56
Q93015	N-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2)	EBI-24640795	0.56
Q06546	GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60)	EBI-24716574	0.56
Q6NX45	Zinc finger protein 774	EBI-25275432	0.56
O14508	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)	EBI-23924597	0.56
Q52LG2	Keratin-associated protein 13-2	EBI-24408520	0.56
Q07627	Keratin-associated protein 1-1 (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7)	EBI-24428974	0.56
Q15323	Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1) (Keratin-31) (K31)	EBI-24437382	0.56
Q5T749	Keratinocyte proline-rich protein (hKPRP)	EBI-24469802	0.56
P27918	Properdin (Complement factor P)	EBI-24556586	0.56
Q9Y6H3	Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-) (Ku70-binding protein 3) (XRCC6-binding protein 1)	EBI-24559916	0.56
O43559	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FGFR-signaling adaptor SNT2) (Suc1-associated neurotrophic factor target 2) (SNT-2)	EBI-24586436	0.56
Q7RTU4	Class A basic helix-loop-helix protein 9 (bHLHa9) (Class F basic helix-loop-helix factor 42) (bHLHf42)	EBI-24593098	0.56
Q6P1L6	Zinc finger protein 343	EBI-24603190	0.56
Q9BS75	KLHL20 protein (Kelch-like 20 (Drosophila), isoform CRA_a)	EBI-24604089	0.56
Q9Y4P1	Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B)	EBI-21856478	0.35
Q96GV9	Macrophage immunometabolism regulator	EBI-21856478	0.35
Q8WVV4	Protein POF1B (Premature ovarian failure protein 1B)	EBI-21856478	0.35
Q6ZVX7	F-box only protein 50 (NCC receptor protein 1 homolog) (NCCRP-1) (Non-specific cytotoxic cell receptor protein 1 homolog)	EBI-21856478	0.35
Q6BDS2	UHRF1-binding protein 1 (ICBP90-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1)	EBI-21856478	0.35
Q5QP82	DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)	EBI-21856478	0.35
Q3ZCM7	Tubulin beta-8 chain (Tubulin beta 8 class VIII)	EBI-21856478	0.35
Q13509	Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)	EBI-21856478	0.35
P20930	Filaggrin	EBI-21856478	0.35
P32233	Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3) (Translation factor GTPase DRG1) (TRAFAC GTPase DRG1) (EC 3.6.5.-)	EBI-15679531	0.64
Q9Y2A7	Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1)	EBI-28931389	0.35
Q92896	Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160)	EBI-28931389	0.35
Q14566	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	EBI-28931389	0.35
Q13405	39S ribosomal protein L49, mitochondrial (L49mt) (MRP-L49) (Mitochondrial large ribosomal subunit protein mL49) (Neighbor of FAU) (NOF) (Protein NOF1)	EBI-28931389	0.35
Q12888	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	EBI-28931389	0.35
Q06418	Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)	EBI-28931389	0.35
P61081	NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)	EBI-28931389	0.35
P41240	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)	EBI-28931389	0.35
P33993	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	EBI-28931389	0.35
P31350	Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)	EBI-28931389	0.35
P09497	Clathrin light chain B (Lcb)	EBI-28931389	0.35

Cross-References

Database	Links
UNIPROT	O75716 A8K9H9 Q5U0F8 Q96KI2 Q9BUH4 Q9UEN3 Q9UP78
PDB	2BUJ
Pfam	PF00069
PROSITE	PS50011 PS00108
OMIM	604719
DisGeNET	8576

Serine/threonine-protein kinase 16 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 2BUJ)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (3 interactors)

Interactions with other proteins (110 interactors)

Cross-References

Database

Links

Description

Description