National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Arachidonate 5-lipoxygenase-activating protein |
| Accession Code | P20292 |
| Gene | ALOX5AP |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 161) |
Structure Viewer (PDB: 6VGI) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. |
| Nuclear Membrane | SL-0182 | The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {Experimental EvidencePubMed:2300173, Experimental EvidencePubMed:8440384}. | Assigned Ontology terms |
Description |
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|---|---|
| Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. {Experimental EvidencePubMed:14770184, Experimental EvidencePubMed:17304054}. | Database Associations |
| OMIM | 601367 603700 |
| DisGeNET | 241 |
Interactions with Nuclear Envelope proteins (3 interactors) |
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Interactions with other proteins (7 interactors) |
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Database | Links |
| UNIPROT | P20292 Q5VV04 |
| PDB | 2Q7M 2Q7R 6VGC 6VGI |
| Pfam | PF01124 |
| PROSITE | PS01297 |
| OMIM | 601367 603700 |
| DisGeNET | 241 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory