NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase - Homo sapiens - NucEnvDB

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Accession Code	P26572
Gene	MGAT1
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 445)
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRP SAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYR TDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTG RDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN

Subcellular Location

Description
Golgi apparatus membrane {Experimental EvidencePubMed:20378551}; Single-pass type II membrane protein {Curator Inference}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:30983867}. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region. {Experimental EvidencePubMed:30983867}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane (GO:0033116) Extracellular Exosome (GO:0070062) Extracellular Vesicle (GO:1903561) Golgi Apparatus (GO:0005794) Golgi Membrane (GO:0000139) Membrane (GO:0016020) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. {Experimental EvidencePubMed:1702225}.
Assigned Ontology terms

Biological Process	In Utero Embryonic Development (GO:0001701) Protein Glycosylation (GO:0006486) Protein N-Linked Glycosylation (GO:0006487) Protein N-Linked Glycosylation Via Asparagine (GO:0018279) UDP-N-Acetylglucosamine Catabolic Process (GO:0006049) Viral Protein Processing (GO:0019082)
Molecular Function	Acetylglucosaminyltransferase Activity (GO:0008375) Alpha-1,3-Mannosylglycoprotein 2-Beta-N-Acetylglucosaminyltransferase Activity (GO:0003827) Manganese Ion Binding (GO:0030145)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O95415	Brain protein I3	EBI-25504004	0.54
Interactions with other proteins (13 interactors)

Partner (UniProt)		IntAct	Confidence score
O15198	Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9)	EBI-7263379	0.37
Q16659	Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)	EBI-7211987	0.37
P08563	Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); Spike glycoprotein E2 (E2 envelope glycoprotein); Spike glycoprotein E1 (E1 envelope glycoprotein)]	EBI-11478323	0.40
Q9Z1B5	Mitotic spindle assembly checkpoint protein MAD2A (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)	EBI-10996176	0.35
Q8R034	Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13)	EBI-11003686	0.35
Q91ZJ0	Crossover junction endonuclease MUS81 (EC 3.1.22.-)	EBI-11131714	0.35
Q8IUW5	RELT-like protein 1	EBI-21555862	0.35
Q9BRR6	ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) (RbBP-35)	EBI-21694151	0.35
Q96GX1	Tectonic-2	EBI-21777303	0.35
Q9BYC5	Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)	EBI-21833842	0.35
P03372	Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)	EBI-21302175	0.35
P0DTC3	ORF3a protein (ORF3a) (Accessory protein 3a) (Protein 3a) (Protein U274) (Protein X1)	EBI-26495719	0.35
Q8N488	RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)	EBI-27110926	0.35

Cross-References

Database	Links
UNIPROT	P26572 A8K404 B3KRU8 D3DWR1 Q6IBE3
Pfam	PF03071
OMIM	160995
DisGeNET	4245

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