Receptor of activated protein C kinase 1, N-terminally processed - Homo sapiens

Receptor of activated protein C kinase 1, N-terminally processed (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Receptor of activated protein C kinase 1, N-terminally processed
Accession Code	P63244
Gene	RACK1
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 317)
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR

Structure Viewer (PDB: 4AOW)

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:11312657, Experimental EvidencePubMed:17956333}; Peripheral membrane protein. Cytoplasm {Experimental EvidencePubMed:10849009, Experimental EvidencePubMed:11279199, Experimental EvidencePubMed:12958311, Experimental EvidencePubMed:19785988, Experimental EvidencePubMed:20499158, Experimental EvidencePubMed:20573744}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:11279199, Experimental EvidencePubMed:12958311}. Nucleus {Experimental EvidencePubMed:10849009}. Perikaryon {ECO:0000250\|UniProtKB:P68040}. Cell projection, dendrite {ECO:0000250\|UniProtKB:P68040}. Cell projection, phagocytic cup {ECO:0000269\|PubMed:21347310}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene- transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310). {ECO:0000250\|UniProtKB:P68040, Experimental EvidencePubMed:11279199, ECO:0000269\|PubMed:11884618, Experimental EvidencePubMed:17956333, ECO:0000269\|PubMed:21347310}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Cytosolic Small Ribosomal Subunit (GO:0022627) Dendrite (GO:0030425) Extracellular Exosome (GO:0070062) IRE1-RACK1-PP2A Complex (GO:1990630) Midbody (GO:0030496) Mitochondrion (GO:0005739) Neuronal Cell Body (GO:0043025) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perikaryon (GO:0043204) Perinuclear Region Of Cytoplasm (GO:0048471) Phagocytic Cup (GO:0001891) Small Ribosomal Subunit (GO:0015935)

Biology & Function

Description
Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome- mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). {Experimental EvidencePubMed:11884618, Experimental EvidencePubMed:12589061, Experimental EvidencePubMed:12958311, Experimental EvidencePubMed:17108144, Experimental EvidencePubMed:17244529, Experimental EvidencePubMed:17956333, Experimental EvidencePubMed:18088317, Experimental EvidencePubMed:18258429, Experimental EvidencePubMed:18621736, Experimental EvidencePubMed:19423701, Experimental EvidencePubMed:19674157, Experimental EvidencePubMed:19785988, Experimental EvidencePubMed:20499158, Experimental EvidencePubMed:20541605, Experimental EvidencePubMed:20573744, Experimental EvidencePubMed:20976005, Experimental EvidencePubMed:21212275, Experimental EvidencePubMed:21347310, Experimental EvidencePubMed:23636399, Experimental EvidencePubMed:28132843, Experimental EvidencePubMed:9584165}. (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. {Experimental EvidencePubMed:21347310}. (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs. {Experimental EvidencePubMed:11312657}. (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs. {Experimental EvidencePubMed:28636603}. (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses. {ECO:0000269\|PubMed:25416947}.
Assigned Ontology terms

Biological Process	Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process (GO:0006919) Cell Cycle (GO:0007049) Cellular Response To Glucose Stimulus (GO:0071333) Cellular Response To Growth Factor Stimulus (GO:0071363) Cytoplasmic Translation (GO:0002181) Gastrulation (GO:0007369) Negative Regulation Of Cell Growth (GO:0030308) Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response (GO:1900102) Negative Regulation Of Gene Expression (GO:0010629) Negative Regulation Of Hydrogen Peroxide-Induced Neuron Death (GO:1903208) Negative Regulation Of Peptidyl-Serine Phosphorylation (GO:0033137) Negative Regulation Of Phagocytosis (GO:0050765) Negative Regulation Of Protein Binding (GO:0032091) Negative Regulation Of Protein Kinase B Signaling (GO:0051898) Negative Regulation Of Smoothened Signaling Pathway (GO:0045879) Negative Regulation Of Translation (GO:0017148) Negative Regulation Of Wnt Signaling Pathway (GO:0030178) Pigmentation (GO:0043473) Positive Regulation Of Apoptotic Process (GO:0043065) Positive Regulation Of Cell Migration (GO:0030335) Positive Regulation Of Cyclic-Nucleotide Phosphodiesterase Activity (GO:0051343) Positive Regulation Of Gastrulation (GO:2000543) Positive Regulation Of Golgi To Plasma Membrane Protein Transport (GO:0042998) Positive Regulation Of GTPase Activity (GO:0043547) Positive Regulation Of Intrinsic Apoptotic Signaling Pathway (GO:2001244) Positive Regulation Of Mitochondrial Depolarization (GO:0051901) Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process (GO:0032436) Positive Regulation Of Protein Phosphorylation (GO:0001934) Positive Regulation Of Protein-Containing Complex Assembly (GO:0031334) Protein Ubiquitination (GO:0016567) Regulation Of Cell Cycle (GO:0051726) Regulation Of Cell Division (GO:0051302) Regulation Of Establishment Of Cell Polarity (GO:2000114) Regulation Of Protein Localization (GO:0032880) Rescue Of Stalled Ribosome (GO:0072344) Rhythmic Process (GO:0048511)
Molecular Function	BH3 Domain Binding (GO:0051434) Cadherin Binding (GO:0045296) Cyclin Binding (GO:0030332) Cysteine-Type Endopeptidase Activator Activity Involved In Apoptotic Process (GO:0008656) Enzyme Binding (GO:0019899) Ion Channel Inhibitor Activity (GO:0008200) Molecular Adaptor Activity (GO:0060090) Protein Homodimerization Activity (GO:0042803) Protein Kinase C Binding (GO:0005080) Protein Phosphatase Binding (GO:0019903) Protein Tyrosine Kinase Inhibitor Activity (GO:0030292) Receptor Tyrosine Kinase Binding (GO:0030971) Ribosome Binding (GO:0043022) RNA Binding (GO:0003723) SH2 Domain Binding (GO:0042169) Signaling Adaptor Activity (GO:0035591) Signaling Receptor Binding (GO:0005102)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (8 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P63244	Self	EBI-9685865	0.40
Q8IWX8	Calcium homeostasis endoplasmic reticulum protein	EBI-7723227	0.37
Q92905	COP9 signalosome complex subunit 5	EBI-21325777	0.55
P00533	Epidermal growth factor receptor	EBI-9072870	0.40
P04626	Receptor tyrosine-protein kinase erbB-2	EBI-32721465	0.27
P07948	Tyrosine-protein kinase Lyn	EBI-9072792	0.40
A0A142I5B9	RNA-directed RNA polymerase NS5	EBI-20625330	0.35
P0DTD1	2'-O-methyltransferase nsp16	EBI-25509375	0.35
Interactions with other proteins (238 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9Y561	Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)	EBI-296801	0.51
Q9Y6K9	NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)	EBI-361479	0.00
P60709	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	EBI-353790	0.40
P21246	Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1)	EBI-728946	0.00
Q8NBJ4	Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2)	EBI-728949	0.00
P12236	ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]	EBI-730822	0.00
P38936	Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)	EBI-734149	0.00
Q9UMR2	ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B)	EBI-734245	0.00
Q9Y3Q8	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1)	EBI-759787	0.37
Q1EHW4	Histone deacetylase complex subunit SAP25 (25 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP25) (mSin3A-binding protein)	EBI-922367	0.35
P03255	Early E1A protein (Early E1A 32 kDa protein)	EBI-7140618	0.46
P48551	Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)	EBI-958438	0.58
P13569	Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)	EBI-1170380	0.53
P63167	Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)	EBI-1769001	0.63
O43521	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	EBI-1769058	0.40
O54918	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	EBI-1769191	0.54
P22303	Acetylcholinesterase (AChE) (EC 3.1.1.7)	EBI-1769965	0.53
Q8BT07	Centrosomal protein of 55 kDa (Cep55)	EBI-2559310	0.40
Q8VD62	UPF0696 protein C11orf68 homolog (Basophilic leukemia-expressed protein Bles03) (Protein WF-3)	EBI-2562857	0.40
Q5NHX0	Elongation factor G (EF-G)	EBI-2806664	0.00
Q5NF74	Transketolase (EC 2.2.1.1)	EBI-2806657	0.00
Q6KMS8	Elongation factor P (EF-P)	EBI-2833445	0.00
A0A6L8PL93	Germination protein YpeB	EBI-2833438	0.00
Q81UI7	Protein translocase subunit SecA 2 (EC 7.4.2.8)	EBI-2833459	0.00
Q81U22	Coproporphyrin III ferrochelatase 1 (EC 4.99.1.9)	EBI-2833452	0.00
A0A6L7H0W6	Zinc protease, insulinase family	EBI-2833466	0.00
Q8CZY2	RecBCD enzyme subunit RecC (EC 3.1.11.5) (Exonuclease V subunit RecC) (ExoV subunit RecC) (Helicase/nuclease RecBCD subunit RecC)	EBI-2847653	0.00
A0A0H2W269	Replication-associated recombination protein A	EBI-2847660	0.00
Q8CZR4	2,4-dienoyl-CoA reductase (Putative NADPH dehydrogenase)	EBI-2869177	0.00
Q8D1J6	Putative haloacid dehalogenase-like hydrolase	EBI-2869170	0.00
Q7CHU1	Protein MtfA (Mlc titration factor A)	EBI-2869212	0.00
Q8ZAR3	Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]	EBI-2869205	0.00
A0A5P8YIB0	Asparagine synthetase B (EC 6.3.5.4)	EBI-2869184	0.00
A0A380PMW3	Anti-sigma-E factor RseA (Regulator of SigE) (Sigma-E anti-sigma factor RseA) (Sigma-E factor negative regulatory protein)	EBI-2869191	0.00
A0A0H2W3W7	Flagellar motor switch protein FliN	EBI-2869198	0.00
Q92731	Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)	EBI-2880601	0.35
P40337	von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)	EBI-3507770	0.61
P00325	All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)	EBI-3906988	0.37
P61586	Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)	EBI-3927722	0.37
Q96GD4	Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)	EBI-3935523	0.37
Q92615	La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5)	EBI-3941736	0.74
Q9HC52	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	EBI-3951861	0.35
P42345	Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)	EBI-4369732	0.35
Q6R327	Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)	EBI-4369851	0.35
P61254	60S ribosomal protein L26 (Large ribosomal subunit protein uL24)	EBI-4369851	0.64
P18124	60S ribosomal protein L7 (Large ribosomal subunit protein uL30)	EBI-4369851	0.64
Q9UKV8	Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)	EBI-8660720	0.50
P23396	40S ribosomal protein S3 (EC 4.2.99.18) (Small ribosomal subunit protein uS3)	EBI-8660895	0.71
Q16659	Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)	EBI-7208705	0.37
Q6QDQ4	Nucleoprotein (Nucleocapsid protein)	EBI-5276631	0.35
O75928	E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)	EBI-7626183	0.40
Q8C5D8	E3 SUMO-protein ligase PIAS2 (EC 2.3.2.27) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) (RING-type E3 ubiquitin transferase PIAS2)	EBI-7626323	0.27
Q9NR09	Baculoviral IAP repeat-containing protein 6 (EC 2.3.2.27) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (RING-type E3 ubiquitin transferase BIRC6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)	EBI-5654605	0.00
Q8WWY3	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31)	EBI-7733021	0.37
Q13123	Protein Red (Cytokine IK) (IK factor) (Protein RER)	EBI-7738872	0.37
Q9BRX9	WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)	EBI-7744956	0.37
Q96DF8	Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2)	EBI-7747320	0.37
P55795	Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]	EBI-7760044	0.37
P12830	Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	EBI-6083772	0.27
Q77M19	V protein	EBI-6156361	0.35
P19320	Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106)	EBI-6189915	0.35
Q9JKL7	Splicing regulatory glutamine/lysine-rich protein 1 (SR-related protein of 86 kDa) (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12)	EBI-6452273	0.35
Q08752	Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D)	EBI-6467805	0.59
Q86VP6	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)	EBI-21322532	0.35
Q13616	Cullin-1 (CUL-1)	EBI-21323857	0.35
Q13618	Cullin-3 (CUL-3)	EBI-21329068	0.35
Q4VGL6	Roquin-1 (Roquin) (EC 2.3.2.27) (Protein Sanroque) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1)	EBI-8759371	0.35
P0C090	Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING-type E3 ubiquitin transferase Roquin-2)	EBI-8759987	0.35
Q9NWQ8	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)	EBI-9072771	0.40
P05771	Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)	EBI-9072870	0.40
P03206	Trans-activator protein BZLF1 (EB1) (Zebra)	EBI-9347475	0.58
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	EBI-9515510	0.35
Q99497	Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124)	EBI-9685618	0.58
Q16666	Gamma-interferon-inducible protein 16 (Ifi-16) (Interferon-inducible myeloid differentiation transcriptional activator)	EBI-9995438	0.35
P41218	Myeloid cell nuclear differentiation antigen	EBI-9996028	0.35
P19838	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	EBI-11322417	0.35
P05412	Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)	EBI-11323169	0.35
Q6ZWV7	60S ribosomal protein L35	EBI-10997876	0.35
P23116	Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Centrosomin) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (p162)	EBI-11020127	0.35
P27635	60S ribosomal protein L10 (Laminin receptor homolog) (Large ribosomal subunit protein uL16) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM)	EBI-11035646	0.35
Q99PL5	Ribosome-binding protein 1 (Ribosome receptor protein) (RRp) (mRRp)	EBI-11066888	0.35
P06748	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)	EBI-11145880	0.35
Q96EQ0	Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2)	EBI-11152414	0.35
P48039	Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)	EBI-11576149	0.37
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54)	EBI-24285633	0.56
Q9NZN8	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2)	EBI-24339799	0.56
Q14694	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)	EBI-24503222	0.56
Q13895	Bystin	EBI-24793226	0.56
Q9H000	E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)	EBI-24393937	0.56
Q14194	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)	EBI-24451162	0.56
Q96B67	Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)	EBI-24535923	0.56
Q86UU5	Gametogenetin	EBI-24569623	0.56
Q86WP2	Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein)	EBI-24635039	0.56
Q0P631	TMEM131 protein	EBI-24637360	0.56
O43309	Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96)	EBI-25272992	0.56
P35609	Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)	EBI-12698011	0.56
P53041	Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)	EBI-14023934	0.35
Q8NI37	Protein phosphatase PTC7 homolog (EC 3.1.3.16) (T-cell activation protein phosphatase 2C) (TA-PP2C) (T-cell activation protein phosphatase 2C-like)	EBI-14026943	0.35
Q8IVT5	Kinase suppressor of Ras 1 (EC 2.7.11.1)	EBI-14035332	0.35
Q9NUD5	Zinc finger CCHC domain-containing protein 3	EBI-21868538	0.35
Q9HCJ0	Trinucleotide repeat-containing gene 6C protein	EBI-21868538	0.35
P46013	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	EBI-21868538	0.35
P42694	Probable helicase with zinc finger domain (EC 3.6.4.-) (Down-regulated in human cancers protein)	EBI-21868538	0.35
Q71RC2	La-related protein 4 (La ribonucleoprotein domain family member 4)	EBI-21877645	0.40
Q5MNZ9	WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa)	EBI-21877614	0.35
P54645	5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)	EBI-16361875	0.35
P80386	5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) (5'-AMP-activated protein kinase 40 kDa subunit)	EBI-16362252	0.35
O75530	Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)	EBI-15825729	0.53
Q9NY59	Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II)	EBI-15825773	0.40
P01375	Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]	EBI-15825849	0.35
Q9HCE5	N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14)	EBI-20595531	0.35
Q0VD86	Protein INCA1 (Inhibitor of CDK interacting with cyclin A1)	EBI-20620635	0.51
P51957	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)	EBI-20721387	0.35
P10636	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	EBI-20798291	0.35
A2A935	Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)	EBI-21022882	0.35
P14404	Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein homolog)	EBI-21026252	0.35
O96013	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)	EBI-26962273	0.35
Q5T7N2	LINE-1 type transposase domain-containing protein 1 (ES cell-associated protein 11)	EBI-20993270	0.35
P13693	Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23)	EBI-20992046	0.35
P12004	Proliferating cell nuclear antigen (PCNA) (Cyclin)	EBI-21255323	0.37
P03372	Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)	EBI-21301141	0.35
Q9H3D4	Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)	EBI-25300147	0.37
P46734	Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)	EBI-25377403	0.35
P0DOF2	Matrix protein (Phosphoprotein M2)	EBI-25603126	0.35
P69479	Phosphoprotein (Protein P) (Protein M1)	EBI-25568051	0.35
Q9UKT8	F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)	EBI-25594515	0.68
P0DTC2	Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2']	EBI-25509945	0.35
P0DTD3	Putative ORF9c protein (ORF9c) (Uncharacterized protein 14) (ORF14)	EBI-25510342	0.35
Q5EP34	Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)	EBI-25772822	0.35
P46783	40S ribosomal protein S10 (Small ribosomal subunit protein eS10)	EBI-26597393	0.61
P25398	40S ribosomal protein S12 (Small ribosomal subunit protein eS12)	EBI-26597393	0.50
P62841	40S ribosomal protein S15 (RIG protein) (Small ribosomal subunit protein uS19)	EBI-26597393	0.61
P62249	40S ribosomal protein S16 (Small ribosomal subunit protein uS9)	EBI-26597393	0.61
P08708	40S ribosomal protein S17 (Small ribosomal subunit protein eS17)	EBI-26597393	0.61
P62269	40S ribosomal protein S18 (Ke-3) (Ke3) (Small ribosomal subunit protein uS13)	EBI-26597393	0.61
P39019	40S ribosomal protein S19 (Small ribosomal subunit protein eS19)	EBI-26597393	0.61
P60866	40S ribosomal protein S20 (Small ribosomal subunit protein uS10)	EBI-26597393	0.61
P62851	40S ribosomal protein S25 (Small ribosomal subunit protein eS25)	EBI-26597393	0.61
P62979	Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a (Small ribosomal subunit protein eS31)]	EBI-26597393	0.61
P62857	40S ribosomal protein S28 (Small ribosomal subunit protein eS28)	EBI-26597393	0.61
P62273	40S ribosomal protein S29 (Small ribosomal subunit protein uS14)	EBI-26597393	0.61
P46782	40S ribosomal protein S5 (Small ribosomal subunit protein uS7) [Cleaved into: 40S ribosomal protein S5, N-terminally processed]	EBI-26597393	0.61
P62906	60S ribosomal protein L10a (CSA-19) (Large ribosomal subunit protein uL1) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6)	EBI-26359000	0.50
Q96L21	60S ribosomal protein L10-like (Large ribosomal subunit protein uL16-like)	EBI-26359000	0.50
P62913	60S ribosomal protein L11 (CLL-associated antigen KW-12) (Large ribosomal subunit protein uL5)	EBI-26359000	0.50
P26373	60S ribosomal protein L13 (Breast basic conserved protein 1) (Large ribosomal subunit protein eL13)	EBI-26359000	0.50
P40429	60S ribosomal protein L13a (23 kDa highly basic protein) (Large ribosomal subunit protein uL13)	EBI-26359000	0.50
P50914	60S ribosomal protein L14 (CAG-ISL 7) (Large ribosomal subunit protein eL14)	EBI-26359000	0.50
P61313	60S ribosomal protein L15 (Large ribosomal subunit protein eL15)	EBI-26359000	0.50
P18621	60S ribosomal protein L17 (60S ribosomal protein L23) (Large ribosomal subunit protein uL22) (PD-1)	EBI-26359000	0.50
Q07020	60S ribosomal protein L18 (Large ribosomal subunit protein eL18)	EBI-26359000	0.50
Q02543	60S ribosomal protein L18a (Large ribosomal subunit protein eL20)	EBI-26359000	0.50
P84098	60S ribosomal protein L19 (Large ribosomal subunit protein eL19)	EBI-26359000	0.50
P46778	60S ribosomal protein L21 (Large ribosomal subunit protein eL21)	EBI-26359000	0.50
P35268	60S ribosomal protein L22 (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) (Large ribosomal subunit protein eL22)	EBI-26359000	0.50
P62829	60S ribosomal protein L23 (60S ribosomal protein L17) (Large ribosomal subunit protein uL14)	EBI-26359000	0.50
P62750	60S ribosomal protein L23a (Large ribosomal subunit protein uL23)	EBI-26359000	0.50
P83731	60S ribosomal protein L24 (60S ribosomal protein L30) (Large ribosomal subunit protein eL24)	EBI-26359000	0.50
P61353	60S ribosomal protein L27 (Large ribosomal subunit protein eL27)	EBI-26359000	0.50
P46776	60S ribosomal protein L27a (Large ribosomal subunit protein uL15)	EBI-26359000	0.50
P46779	60S ribosomal protein L28 (Large ribosomal subunit protein eL28)	EBI-26359000	0.50
P47914	60S ribosomal protein L29 (Cell surface heparin-binding protein HIP) (Large ribosomal subunit protein eL29)	EBI-26359000	0.50
P62888	60S ribosomal protein L30 (Large ribosomal subunit protein eL30)	EBI-26359000	0.50
P62899	60S ribosomal protein L31 (Large ribosomal subunit protein eL31)	EBI-26359000	0.50
P62910	60S ribosomal protein L32 (Large ribosomal subunit protein eL32)	EBI-26359000	0.50
P49207	60S ribosomal protein L34 (Large ribosomal subunit protein eL34)	EBI-26359000	0.50
P42766	60S ribosomal protein L35 (Large ribosomal subunit protein uL29)	EBI-26359000	0.50
P18077	60S ribosomal protein L35a (Cell growth-inhibiting gene 33 protein) (Large ribosomal subunit protein eL33)	EBI-26359000	0.50
Q9Y3U8	60S ribosomal protein L36 (Large ribosomal subunit protein eL36)	EBI-26359000	0.50
P83881	60S ribosomal protein L36a (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) (Large ribosomal subunit protein eL42)	EBI-26359000	0.50
P61927	60S ribosomal protein L37 (G1.16) (Large ribosomal subunit protein eL37)	EBI-26359000	0.50
P61513	60S ribosomal protein L37a (Large ribosomal subunit protein eL43)	EBI-26359000	0.50
P63173	60S ribosomal protein L38 (Large ribosomal subunit protein eL38)	EBI-26359000	0.50
P62891	60S ribosomal protein L39 (Large ribosomal subunit protein eL39)	EBI-26359000	0.50
P39023	60S ribosomal protein L3 (HIV-1 TAR RNA-binding protein B) (TARBP-B) (Large ribosomal subunit protein uL3)	EBI-26359000	0.50
P62987	Ubiquitin-60S ribosomal protein L40 (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (Large ribosomal subunit protein eL40)]	EBI-26359000	0.50
P62945	60S ribosomal protein L41 (HG12) (Large ribosomal subunit protein eL41)	EBI-26359000	0.50
P36578	60S ribosomal protein L4 (60S ribosomal protein L1) (Large ribosomal subunit protein uL4)	EBI-26359000	0.50
P46777	60S ribosomal protein L5 (Large ribosomal subunit protein uL18)	EBI-26359000	0.50
Q02878	60S ribosomal protein L6 (Large ribosomal subunit protein eL6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107)	EBI-26359000	0.50
P62424	60S ribosomal protein L7a (Large ribosomal subunit protein eL8) (PLA-X polypeptide) (Surfeit locus protein 3)	EBI-26359000	0.50
P62917	60S ribosomal protein L8 (Large ribosomal subunit protein uL2)	EBI-26359000	0.50
P32969	60S ribosomal protein L9 (Large ribosomal subunit protein uL6)	EBI-26359000	0.50
P62280	40S ribosomal protein S11 (Small ribosomal subunit protein uS17)	EBI-26359000	0.50
P62277	40S ribosomal protein S13 (Small ribosomal subunit protein uS15)	EBI-26359000	0.50
P62263	40S ribosomal protein S14 (Small ribosomal subunit protein uS11)	EBI-26359000	0.50
P62244	40S ribosomal protein S15a (Small ribosomal subunit protein uS8)	EBI-26359000	0.50
P63220	40S ribosomal protein S21 (Small ribosomal subunit protein eS21)	EBI-26359000	0.50
P62266	40S ribosomal protein S23 (Small ribosomal subunit protein uS12)	EBI-26359000	0.50
P62847	40S ribosomal protein S24 (Small ribosomal subunit protein eS24)	EBI-26359000	0.50
P62854	40S ribosomal protein S26 (Small ribosomal subunit protein eS26)	EBI-26359000	0.50
P42677	40S ribosomal protein S27 (Metallopan-stimulin 1) (MPS-1) (Small ribosomal subunit protein eS27)	EBI-26359000	0.50
P15880	40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) (Small ribosomal subunit protein uS5)	EBI-26359000	0.50
P62861	FAU ubiquitin-like and ribosomal protein S30 [Cleaved into: Ubiquitin-like protein FUBI; 40S ribosomal protein S30 (Small ribosomal subunit protein eS30)]	EBI-26359000	0.50
P61247	40S ribosomal protein S3a (Small ribosomal subunit protein eS1) (v-fos transformation effector protein) (Fte-1)	EBI-26359000	0.50
P62701	40S ribosomal protein S4, X isoform (SCR10) (Single copy abundant mRNA protein) (Small ribosomal subunit protein eS4)	EBI-26359000	0.50
P62753	40S ribosomal protein S6 (Phosphoprotein NP33) (Small ribosomal subunit protein eS6)	EBI-26359000	0.50
P62081	40S ribosomal protein S7 (Small ribosomal subunit protein eS7)	EBI-26359000	0.50
P62241	40S ribosomal protein S8 (Small ribosomal subunit protein eS8)	EBI-26359000	0.50
P46781	40S ribosomal protein S9 (Small ribosomal subunit protein uS4)	EBI-26359000	0.50
P08865	40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) (Small ribosomal subunit protein uS2)	EBI-26359000	0.50
Q09161	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)	EBI-26396507	0.35
P52298	Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)	EBI-26399642	0.35
Q99608	Necdin	EBI-26955247	0.27
A0A0F6B2Z0	Type III secretion system effector arginine glycosyltransferase	EBI-27034162	0.35
Q13363	C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)	EBI-27044482	0.35
F1PAA9	Cadherin-1 (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	EBI-27079701	0.27
P35226	Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)	EBI-27109494	0.35
O00311	Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)	EBI-28930020	0.35
O43318	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)	EBI-28931001	0.35
P22612	cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)	EBI-28934688	0.35
P36507	Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)	EBI-28935019	0.35
P43405	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)	EBI-28935283	0.35
P53350	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)	EBI-28938281	0.35
P57078	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)	EBI-28938584	0.35
Q05513	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)	EBI-28938998	0.35
Q16566	Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR)	EBI-28941485	0.35
Q16539	Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)	EBI-28941466	0.35
Q2M2I8	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)	EBI-28941588	0.35
Q6PHR2	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)	EBI-28941815	0.35
Q86YV6	Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)	EBI-28942265	0.35
Q8IY84	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase)	EBI-28942464	0.35
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)	EBI-28944101	0.35
Q9H1R3	Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)	EBI-28946206	0.35
Q9NQU5	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)	EBI-28946365	0.35
Q9Y2K2	Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)	EBI-28947183	0.35
P78362	SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]	EBI-28948274	0.35
Q8NCK7	Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11)	EBI-27105115	0.35
P0DTC9	Nucleoprotein (N) (Nucleocapsid protein) (NC) (Protein N)	EBI-28955760	0.35
Q9BZB8	Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)	EBI-29014562	0.27
Q8WV16	DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A)	EBI-30863977	0.35
P29376	Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)	EBI-32718970	0.35
Q9UM73	ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)	EBI-32719830	0.27
P17948	Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)	EBI-32722433	0.27
P36888	Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)	EBI-32722567	0.27
P08069	Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]	EBI-32722947	0.27
Q96Q04	Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Lemur tyrosine kinase 3)	EBI-32723651	0.27
O15146	Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)	EBI-32724025	0.27

Cross-References

Database	Links
UNIPROT	P63244 B3KTJ0 D3DWS0 P25388 P99049 Q53HU2 Q5J8M6 Q5VLR4 Q6FH47
PDB	4AOW 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I
Pfam	PF00400
PROSITE	PS00678 PS50082 PS50294
OMIM	176981
DisGeNET	10399

Receptor of activated protein C kinase 1, N-terminally processed (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 4AOW)

Subcellular Location

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Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

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Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (8 interactors)

Interactions with other proteins (238 interactors)

Cross-References

Database

Links

Description

Description