Receptor tyrosine-protein kinase erbB-2 - Homo sapiens

Receptor tyrosine-protein kinase erbB-2 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	Receptor tyrosine-protein kinase erbB-2
Accession Code	P04626
Gene	ERBB2
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 1255)
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEV QGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQ LCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQ EVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVF ETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHC LPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDK GCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQL MPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD GGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAG GMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPL PSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV

Structure Viewer (PDB: 1N8Z)

Subcellular Location

Description
Cell membrane {Experimental EvidencePubMed:32381043}; Single-pass type I membrane protein {Sequence Analysis}. Cell projection, ruffle membrane {Experimental EvidencePubMed:34380438}; Single-pass type I membrane protein {Sequence Analysis}. Note=Internalized from the cell membrane in response to EGF stimulation. {Experimental EvidencePubMed:32381043}. [Isoform 1]: Cell membrane {ECO:0000269\|PubMed:31138794, ECO:0000269\|PubMed:33497358}; Single-pass type I membrane protein {Sequence Analysis}. Early endosome {ECO:0000269\|PubMed:31138794}. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). {ECO:0000269\|PubMed:31138794}. [Isoform 2]: Cytoplasm. Nucleus. [Isoform 3]: Cytoplasm. Nucleus.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Apical Plasma Membrane (GO:0016324) Basal Plasma Membrane (GO:0009925) Basolateral Plasma Membrane (GO:0016323) Cytosol (GO:0005829) Early Endosome (GO:0005769) Endosome Membrane (GO:0010008) ERBB3:ERBB2 Complex (GO:0038143) Myelin Sheath (GO:0043209) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Receptor Complex (GO:0043235) Obsolete Spanning Component Of Plasma Membrane (GO:0044214)

Biology & Function

Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {Curator Inference}. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {Experimental EvidencePubMed:10358079, Experimental EvidencePubMed:15380516, Experimental EvidencePubMed:21555369}.
Assigned Ontology terms

Biological Process	Cell Surface Receptor Signaling Pathway (GO:0007166) Cellular Response To Epidermal Growth Factor Stimulus (GO:0071364) Cellular Response To Growth Factor Stimulus (GO:0071363) Enzyme-Linked Receptor Protein Signaling Pathway (GO:0007167) ERBB2-EGFR Signaling Pathway (GO:0038134) ERBB2-ERBB3 Signaling Pathway (GO:0038133) ERBB2-ERBB4 Signaling Pathway (GO:0038135) Heart Development (GO:0007507) Immature T Cell Proliferation In Thymus (GO:0033080) Intracellular Signal Transduction (GO:0035556) Motor Neuron Axon Guidance (GO:0008045) Myelination (GO:0042552) Negative Regulation Of Immature T Cell Proliferation In Thymus (GO:0033088) Neuromuscular Junction Development (GO:0007528) Neuron Differentiation (GO:0030182) Oligodendrocyte Differentiation (GO:0048709) Peptidyl-Tyrosine Phosphorylation (GO:0018108) Peripheral Nervous System Development (GO:0007422) Phosphatidylinositol 3-Kinase Signaling (GO:0014065) Positive Regulation Of Cell Adhesion (GO:0045785) Positive Regulation Of Cell Growth (GO:0030307) Positive Regulation Of Cell Population Proliferation (GO:0008284) Positive Regulation Of Epithelial Cell Proliferation (GO:0050679) Positive Regulation Of GTPase Activity (GO:0043547) Positive Regulation Of Kinase Activity (GO:0033674) Positive Regulation Of MAP Kinase Activity (GO:0043406) Positive Regulation Of MAPK Cascade (GO:0043410) Positive Regulation Of Protein Phosphorylation (GO:0001934) Positive Regulation Of Protein Targeting To Membrane (GO:0090314) Positive Regulation Of Transcription By RNA Polymerase I (GO:0045943) Positive Regulation Of Translation (GO:0045727) Protein Autophosphorylation (GO:0046777) Protein Phosphorylation (GO:0006468) Regulation Of Angiogenesis (GO:0045765) Regulation Of ERK1 And ERK2 Cascade (GO:0070372) Regulation Of Microtubule-Based Process (GO:0032886) Signal Transduction (GO:0007165) Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway (GO:0007169) Wound Healing (GO:0042060)
Molecular Function	ATP Binding (GO:0005524) ErbB-3 Class Receptor Binding (GO:0043125) Identical Protein Binding (GO:0042802) Protein C-Terminus Binding (GO:0008022) Protein Heterodimerization Activity (GO:0046982) Protein Phosphatase Binding (GO:0019903) Protein Tyrosine Kinase Activity (GO:0004713) RNA Polymerase I Core Binding (GO:0001042) Transmembrane Receptor Protein Tyrosine Kinase Activity (GO:0004714) Transmembrane Signaling Receptor Activity (GO:0004888)

Disease associations

Description
Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {Experimental EvidencePubMed:15457249}. Note=The gene represented in this entry is involved in disease pathogenesis. Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. {Experimental EvidencePubMed:15457249, Experimental EvidencePubMed:17344846}. Note=The gene represented in this entry is involved in disease pathogenesis. Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {Experimental EvidencePubMed:15457249}. Note=The gene represented in this entry is involved in disease pathogenesis. Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {Experimental EvidencePubMed:15457249, Experimental EvidencePubMed:17344846}. Note=The protein represented in this entry is involved in disease pathogenesis. Note=Chromosomal aberrations involving ERBB2 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with CDK12, leading to CDK12-ERBB2 fusion leading to truncated CDK12 protein not in-frame with ERBB2. {ECO:0000269\|PubMed:21097718}. Visceral neuropathy, familial, 2, autosomal recessive (VSCN2) [MIM:619465]: An autosomal recessive disorder characterized by intestinal dysmotility due to aganglionosis (Hirschsprung disease), hypoganglionosis, and/or chronic intestinal pseudoobstruction. Patients also show peripheral axonal neuropathy, hypotonia, mild developmental delay, unilateral ptosis, and sensorineural hearing loss. {ECO:0000269\|PubMed:33497358}. Note=The disease is caused by variants affecting the gene represented in this entry.
Database Associations
OMIM	137800 164870 167000 211980 613659 619465
DisGeNET	2064

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (41 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O00165	HCLS1-associated protein X-1	EBI-32718334	0.35
O75694	Nuclear pore complex protein Nup155	EBI-32721465	0.27
P04406	Glyceraldehyde-3-phosphate dehydrogenase	EBI-9687897	0.55
Q9UQF2	C-Jun-amino-terminal kinase-interacting protein 1	EBI-7873480	0.59
Q80TH2	Erbin	EBI-7806162	0.37
P04626	Self	EBI-1000502	0.93
P12931	Proto-oncogene tyrosine-protein kinase Src	EBI-8289901	0.71
Q05397	Focal adhesion kinase 1	EBI-2942138	0.54
Q14974	Importin subunit beta-1	EBI-4373084	0.57
P49792	E3 SUMO-protein ligase RanBP2	EBI-4373195	0.46
Q14289	Protein-tyrosine kinase 2-beta	EBI-6589791	0.27
P42704	Leucine-rich PPR motif-containing protein, mitochondrial	EBI-8770853	0.53
P62879	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	EBI-8770853	0.35
Q9P0L0	Vesicle-associated membrane protein-associated protein A	EBI-8770853	0.55
P57088	Transmembrane protein 33	EBI-8770853	0.35
Q8IWX7	Protein unc-45 homolog B	EBI-9363369	0.40
Q15256	Receptor-type tyrosine-protein phosphatase R	EBI-20977323	0.51
Q6ZMQ8	Serine/threonine-protein kinase LMTK1	EBI-25367655	0.37
Q14643	Inositol 1,4,5-trisphosphate receptor type 1	EBI-25368139	0.37
Q8NDT2	Putative RNA-binding protein 15B	EBI-25368403	0.37
Q93045	Stathmin-2	EBI-25368535	0.37
Q9NXE4	Sphingomyelin phosphodiesterase 4	EBI-25368491	0.37
Q9H6X4	Transmembrane protein 134	EBI-25368557	0.37
Q9H0U4	Ras-related protein Rab-1B	EBI-32718334	0.35
P63244	Receptor of activated protein C kinase 1, N-terminally processed	EBI-32721465	0.27
P43034	Platelet-activating factor acetylhydrolase IB subunit beta	EBI-32721465	0.27
Q8N1F7	Nuclear pore complex protein Nup93	EBI-32721465	0.27
P00519	Tyrosine-protein kinase ABL1	EBI-7881352	0.44
O70248	Amyloid-beta A4 precursor protein-binding family A member 3	EBI-22242478	0.35
P84085	ADP-ribosylation factor 5	EBI-25367743	0.37
Q93084	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	EBI-8770853	0.35
Q9Y6K0	Choline/ethanolaminephosphotransferase 1	EBI-32718334	0.35
Q96LT7	Guanine nucleotide exchange factor C9orf72	EBI-20938756	0.35
Q96S66	Chloride channel CLIC-like protein 1	EBI-32721465	0.27
Q9NXW2	DnaJ homolog subfamily B member 12	EBI-32718334	0.35
P31689	DnaJ homolog subfamily A member 1	EBI-8770853	0.53
O75190	DnaJ homolog subfamily B member 6	EBI-8770853	0.35
Q99704	Docking protein 1	EBI-7878971	0.44
Q03001	Dystonin	EBI-25367963	0.37
P00533	Epidermal growth factor receptor	EBI-702075	0.95
P50402	Emerin	EBI-32718334	0.35
Interactions with other proteins (452 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9H299	SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1) (TNF inhibitory protein B1) (TIP-B1)	EBI-8533023	0.40
P29353	SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)	EBI-8533045	0.82
O00459	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)	EBI-8533204	0.70
P62993	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)	EBI-8533665	0.92
O00443	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)	EBI-641125	0.35
O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)	EBI-641125	0.52
P23727	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)	EBI-7472363	0.40
P43405	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)	EBI-7872191	0.44
P20936	Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)	EBI-7872273	0.59
P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)	EBI-7872323	0.44
Q92569	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)	EBI-7872366	0.59
P27986	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)	EBI-7872561	0.76
P23458	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)	EBI-7872614	0.44
Q9Y490	Talin-1	EBI-7872742	0.44
Q7KZ85	Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)	EBI-7872692	0.44
Q63HR2	Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)	EBI-7872814	0.44
Q13387	C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)	EBI-7873391	0.44
P09769	Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)	EBI-7873560	0.44
O14796	SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)	EBI-7873641	0.44
P98077	SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)	EBI-7873711	0.44
Q8TEW6	Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5)	EBI-7873800	0.44
P46109	Crk-like protein	EBI-7873890	0.44
P46108	Adapter molecule crk (Proto-oncogene c-Crk) (p38)	EBI-7873995	0.44
P42684	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)	EBI-7874156	0.44
Q9NSE2	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)	EBI-7874052	0.44
P42681	Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)	EBI-7877479	0.44
P42224	Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)	EBI-7877610	0.57
O15524	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)	EBI-7877654	0.44
Q9H6Q3	Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)	EBI-7877680	0.44
Q13239	Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)	EBI-7877723	0.44
Q8WYP3	Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2)	EBI-7877809	0.44
Q13671	Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)	EBI-7877852	0.44
Q7Z7G1	Cytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer)	EBI-7878187	0.44
Q08881	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)	EBI-7878322	0.44
O14654	Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)	EBI-7878365	0.44
P35568	Insulin receptor substrate 1 (IRS-1)	EBI-7878450	0.44
Q14451	Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)	EBI-7878494	0.78
Q7Z6G8	Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)	EBI-7878520	0.44
Q6PKX4	Docking protein 6 (Downstream of tyrosine kinase 6)	EBI-7878747	0.44
Q8WV28	B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)	EBI-7879040	0.44
P51451	Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)	EBI-7879084	0.44
O95704	Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2)	EBI-7879155	0.44
O00213	Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)	EBI-7879203	0.44
Q92625	Ankyrin repeat and SAM domain-containing protein 1A (Odin)	EBI-7879248	0.44
Q9UKW4	Guanine nucleotide exchange factor VAV3 (VAV-3)	EBI-7879334	0.44
P52735	Guanine nucleotide exchange factor VAV2 (VAV-2)	EBI-7879377	0.44
Q96D37	Proto-oncogene vav (VAV1 protein)	EBI-7879875	0.44
Q68CZ2	Tensin-3 (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6)	EBI-7879918	0.44
P78314	SH3 domain-binding protein 2 (3BP-2)	EBI-7880141	0.44
Q9NP31	SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)	EBI-7880184	0.44
Q06124	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)	EBI-7880270	0.59
P16885	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)	EBI-7880409	0.57
O43639	Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)	EBI-7880962	0.44
O75791	GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)	EBI-7881093	0.57
O75553	Disabled homolog 1	EBI-7881180	0.44
P51813	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)	EBI-7881223	0.44
O75815	Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)	EBI-7881266	0.44
P40763	Signal transducer and activator of transcription 3 (Acute-phase response factor)	EBI-7883743	0.78
Q92529	SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)	EBI-7883839	0.44
P42679	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)	EBI-7884171	0.59
Q9UQQ2	SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)	EBI-7884193	0.44
P16591	Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)	EBI-7884310	0.44
Q6ZV89	SH2 domain-containing protein 5	EBI-7884338	0.44
P15882	N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2)	EBI-7884418	0.44
P42680	Tyrosine-protein kinase Tec (EC 2.7.10.2)	EBI-7891341	0.44
Q9BRG2	SH2 domain-containing protein 3A (Novel SH2-containing protein 1)	EBI-7892184	0.44
O14492	SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)	EBI-7893084	0.44
P21860	Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)	EBI-875459	0.97
Q15303	Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]	EBI-875465	0.82
P62157	Calmodulin (CaM)	EBI-1257031	0.40
P62161	Calmodulin-1	EBI-1257044	0.44
P16070	CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)	EBI-1774582	0.35
P08575	Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)	EBI-2256762	0.00
Q15262	Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)	EBI-2257483	0.00
P23470	Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)	EBI-2258522	0.00
P23471	Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)	EBI-2263296	0.00
P23467	Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)	EBI-2264176	0.00
Q12913	Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)	EBI-2264587	0.00
Q16827	Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)	EBI-2265156	0.00
P26045	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)	EBI-2266001	0.00
Q05209	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)	EBI-3952071	0.59
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)	EBI-2266470	0.00
Q02297	Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]	EBI-2460992	0.44
P41240	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)	EBI-8677066	0.35
O95980	Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)	EBI-8569595	0.56
Q9Y316	Protein MEMO1 (C21orf19-like protein) (Hepatitis C virus NS5A-transactivated protein 7) (HCV NS5A-transactivated protein 7) (Mediator of ErbB2-driven cell motility 1) (Mediator of cell motility 1) (Memo-1)	EBI-7072663	0.40
O14980	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)	EBI-4373229	0.56
Q00610	Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)	EBI-4373234	0.35
Q15075	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2)	EBI-4373273	0.57
P50570	Dynamin-2 (EC 3.6.5.5)	EBI-4373368	0.35
P42566	Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)	EBI-4373373	0.43
P60709	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	EBI-4373715	0.54
O95602	DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194)	EBI-4373923	0.57
Q9UBN7	Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)	EBI-4398276	0.55
P15309	Prostatic acid phosphatase (PAP) (EC 3.1.3.2) (5'-nucleotidase) (5'-NT) (EC 3.1.3.5) (Acid phosphatase 3) (Ecto-5'-nucleotidase) (Protein tyrosine phosphatase ACP3) (EC 3.1.3.48) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]	EBI-8681281	0.47
P98172	Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]	EBI-5451673	0.46
P46940	Ras GTPase-activating-like protein IQGAP1 (p195)	EBI-5458762	0.60
O43157	Plexin-B1 (Semaphorin receptor SEP)	EBI-6092574	0.40
O75367	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)	EBI-6249307	0.56
P06401	Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)	EBI-6255956	0.35
Q96SB4	SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)	EBI-6659552	0.44
P08238	Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)	EBI-6424213	0.79
P35070	Probetacellulin [Cleaved into: Betacellulin (BTC)]	EBI-6590054	0.27
P14923	Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)	EBI-6592604	0.27
P01135	Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)]	EBI-6593605	0.27
Q99650	Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB)	EBI-6595538	0.27
Q16543	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]	EBI-8770673	0.69
Q03169	Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein)	EBI-8770853	0.35
P25686	DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)	EBI-8770853	0.35
P33947	ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)	EBI-8770853	0.35
Q9HCY8	Protein S100-A14 (S100 calcium-binding protein A14) (S114)	EBI-8770853	0.35
Q3ZCQ8	Mitochondrial import inner membrane translocase subunit TIM50	EBI-8770853	0.53
P36542	ATP synthase subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit)	EBI-8770853	0.53
P08195	4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)	EBI-8770853	0.35
P07355	Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)	EBI-8770853	0.35
Q9NVI7	ATPase family AAA domain-containing protein 3A	EBI-8770853	0.53
P07900	Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)	EBI-8770853	0.86
O60884	DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14)	EBI-8770853	0.57
P15880	40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) (Small ribosomal subunit protein uS5)	EBI-8770853	0.35
O00483	Cytochrome c oxidase subunit NDUFA4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit)	EBI-8770853	0.53
P02786	Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]	EBI-8770853	0.67
P27348	14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)	EBI-8770853	0.35
P55795	Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]	EBI-8770853	0.35
Q00325	Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3)	EBI-8770853	0.53
P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)	EBI-8770853	0.35
Q9H254	Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)	EBI-8770853	0.35
P11021	Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)	EBI-8770853	0.66
P49411	Elongation factor Tu, mitochondrial (EF-Tu) (P43)	EBI-8770853	0.35
P61619	Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)	EBI-8770853	0.53
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)	EBI-8770853	0.35
Q99959	Plakophilin-2	EBI-8770853	0.35
P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)	EBI-8770853	0.35
Q9BVV7	Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)	EBI-8770853	0.53
Q9P035	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1)	EBI-8770853	0.35
Q92504	Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)	EBI-8770853	0.53
Q8TF42	Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)	EBI-8770853	0.35
Q9UJM3	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (MIG-6)	EBI-8770853	0.66
O95292	Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)	EBI-8770853	0.67
Q9HAV0	Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)	EBI-8770853	0.35
P43307	Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)	EBI-8770853	0.35
Q8WUY1	Protein THEM6 (Mesenchymal stem cell protein DSCD75) (Thioesterase superfamily member 6)	EBI-8770853	0.53
P35232	Prohibitin 1	EBI-8770853	0.35
Q8NHS0	DnaJ homolog subfamily B member 8	EBI-8770853	0.35
Q99623	Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)	EBI-8770853	0.35
Q9UBM7	7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2)	EBI-8770853	0.35
P53007	Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Mitochondrial citrate carrier) (CIC) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)	EBI-8770853	0.35
P27824	Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)	EBI-8770853	0.57
Q9NTG1	Polycystin family receptor for egg jelly (PKD and REJ homolog) (Polycystic kidney disease and receptor for egg jelly-related protein)	EBI-8770853	0.35
P05023	Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1)	EBI-8770853	0.64
P62873	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)	EBI-8770853	0.35
P10620	Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I)	EBI-8770853	0.35
P16520	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)	EBI-8770853	0.35
Q9GZT3	SRA stem-loop-interacting RNA-binding protein, mitochondrial	EBI-8770853	0.35
O95470	Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)	EBI-8770853	0.35
Q96FQ6	Protein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16)	EBI-8770853	0.35
Q8IXB1	DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)	EBI-8770853	0.35
O95573	Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)	EBI-8770853	0.53
P16615	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)	EBI-8770853	0.35
Q14032	Bile acid-CoA:amino acid N-acyltransferase (BACAT) (BAT) (EC 2.3.1.65) (Bile acid-CoA thioesterase) (Choloyl-CoA hydrolase) (EC 3.1.2.27) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2)	EBI-8997691	0.37
Q9BU70	tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O)	EBI-8997704	0.37
P49336	Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)	EBI-8997717	0.37
Q14093	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II)	EBI-8997730	0.37
O75474	GSK-3-binding protein FRAT2 (Frequently rearranged in advanced T-cell lymphomas 2) (FRAT-2)	EBI-8997756	0.37
P09467	Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)	EBI-8997743	0.37
P37058	17-beta-hydroxysteroid dehydrogenase type 3 (17-beta-HSD 3) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 2) (Testicular 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase 3) (EC 1.1.1.64)	EBI-8997769	0.37
Q9P1Z9	Coiled-coil domain-containing protein 180	EBI-8997782	0.37
Q02750	Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)	EBI-8997795	0.37
Q6FHJ7	Secreted frizzled-related protein 4 (sFRP-4) (Frizzled protein, human endometrium) (FrpHE)	EBI-8997821	0.37
Q15797	Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)	EBI-8997834	0.37
O75820	Zinc finger protein 189	EBI-8997860	0.37
P01137	Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]	EBI-8997847	0.37
O94812	BAI1-associated protein 3 (BAP3) (Brain-specific angiogenesis inhibitor I-associated protein 3)	EBI-9064260	0.37
P08133	Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70)	EBI-9064247	0.37
P41252	Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)	EBI-9064312	0.37
P51797	H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6)	EBI-9064273	0.37
Q9P2T1	GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)	EBI-9064286	0.55
Q00341	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)	EBI-9064299	0.37
Q9BUL5	PHD finger protein 23 (PDH-containing protein JUNE-1)	EBI-9064351	0.37
Q8IW90	MTCH1 protein	EBI-9064325	0.37
Q96DR8	Mucin-like protein 1 (Protein BS106) (Small breast epithelial mucin)	EBI-9064338	0.37
Q9H3H9	Transcription elongation factor A protein-like 2 (TCEA-like protein 2) (Transcription elongation factor S-II protein-like 2)	EBI-9064403	0.37
P49005	DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50)	EBI-9064364	0.37
P07602	Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]	EBI-9064377	0.37
Q9Y6E0	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]	EBI-9064390	0.37
Q9Y5J1	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50)	EBI-9064442	0.37
Q15904	V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)	EBI-9064416	0.37
Q8N6N2	Tetratricopeptide repeat protein 9B (TPR repeat protein 9B)	EBI-9064429	0.37
P05093	Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)	EBI-9067433	0.37
Q14627	Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)	EBI-9067472	0.37
O94923	D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase)	EBI-9067459	0.37
Q9Y337	Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)	EBI-9067485	0.37
O95274	Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)	EBI-9067498	0.37
P11245	Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (N-acetyltransferase type 2) (NAT-2) (Polymorphic arylamine N-acetyltransferase) (PNAT)	EBI-9067511	0.37
Q9P2W1	Homologous-pairing protein 2 homolog (Nuclear receptor coactivator GT198) (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein)	EBI-9067537	0.37
Q9GZV8	PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14)	EBI-9067524	0.37
Q9BYZ6	Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83)	EBI-9067550	0.37
Q92748	Thyroid hormone-inducible hepatic protein (Spot 14 protein) (S14) (SPOT14)	EBI-9067563	0.37
Q13451	Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)	EBI-9363176	0.40
Q3UJD6	Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19)	EBI-9363211	0.40
Q6PK50	HSP90AB1 protein	EBI-9363230	0.40
Q9BPW0	Serine/threonine-protein phosphatase (EC 3.1.3.16)	EBI-9363250	0.40
P58340	Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1)	EBI-9363270	0.40
Q9BTE6	Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1)	EBI-9363294	0.40
Q9Y266	Nuclear migration protein nudC (Nuclear distribution protein C homolog)	EBI-9363318	0.40
Q13200	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)	EBI-9363339	0.40
P31948	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)	EBI-9363393	0.57
Q8IVD9	NudC domain-containing protein 3	EBI-9363414	0.40
B4DYC6	cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1 (SUGT1), mRNA	EBI-9363439	0.40
Q96BE0	Heat shock protein family A (Hsp70) member 8b	EBI-9363465	0.40
Q9HB71	Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein)	EBI-9363493	0.57
Q15773	Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2)	EBI-9363541	0.40
Q53FC7	Heat shock 70kDa protein 6 (HSP70B') variant	EBI-9363565	0.40
Q13882	Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)	EBI-9293590	0.63
P14618	Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)	EBI-9353947	0.44
P06241	Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)	EBI-9396596	0.56
P15311	Ezrin (Cytovillin) (Villin-2) (p81)	EBI-9690211	0.37
P06461	Probable protein E5B	EBI-11723785	0.35
P0C739	Protein BNLF2a	EBI-11725101	0.35
P0CK58	Apoptosis regulator BALF1	EBI-11732874	0.35
P48651	Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I)	EBI-11145552	0.35
P26641	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)	EBI-11145552	0.35
O15260	Surfeit locus protein 4	EBI-11145552	0.35
Q9H9Y6	DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)	EBI-11145552	0.35
Q92973	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)	EBI-11145552	0.35
Q3V6T2	Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)	EBI-11145552	0.35
P11498	Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)	EBI-11145552	0.35
Q8ND82	Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633)	EBI-11145552	0.35
Q9Y251	Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]	EBI-11145552	0.35
Q969S3	Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9)	EBI-11145552	0.35
Q99952	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)	EBI-12739796	0.56
P22681	E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)	EBI-13637258	0.40
P04201	Proto-oncogene Mas	EBI-21538834	0.35
Q8TDQ0	Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)	EBI-21556046	0.35
P43115	Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)	EBI-21607127	0.35
P37173	TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)	EBI-21668347	0.35
P40259	B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)	EBI-21668943	0.35
Q58DX5	Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2)	EBI-21782845	0.35
P24394	Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]	EBI-21800565	0.35
Q8NBA8	tRNA-uridine aminocarboxypropyltransferase 2 (EC 2.5.1.25) (DTW domain-containing protein 2)	EBI-21829890	0.35
P14625	Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)	EBI-16072470	0.40
Q93034	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)	EBI-16247158	0.40
O14522	Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)	EBI-20977013	0.37
Q92729	Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)	EBI-20977022	0.37
Q9H0C8	Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16)	EBI-20980596	0.37
O95147	Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (MKP-1-like protein tyrosine phosphatase) (MKP-L) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6)	EBI-20980636	0.37
Q8NEJ0	Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 20) (LMW-DSP20)	EBI-20980646	0.37
Q8WTR2	Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1)	EBI-20980656	0.37
Q8WUJ0	Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)	EBI-20980666	0.37
P29350	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)	EBI-20980616	0.37
P35813	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA)	EBI-20980576	0.37
P49593	Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2)	EBI-20980586	0.37
B4F779	DCC-interacting protein 13-beta (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)	EBI-22242273	0.35
P62078	Mitochondrial import inner membrane translocase subunit Tim8 B (Deafness dystonia protein 2 homolog)	EBI-22242273	0.35
A0A0G2K064	Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48)	EBI-22242273	0.35
Q64537	Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)	EBI-22242273	0.35
Q6AZ23	Caspase-6 (EC 3.4.22.59)	EBI-22242273	0.35
Q62985	SH2B adapter protein 1 (FceRI gamma-chain-interacting protein SH2-B) (SH2 domain-containing protein 1B) (SH2-B PH domain-containing signaling mediator 1)	EBI-22242478	0.35
P41499	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)	EBI-22242478	0.35
F1LM93	Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)	EBI-22242478	0.35
A0A0G2JVN4	Ubiquitin carboxyl-terminal hydrolase 19	EBI-22242478	0.35
P68101	Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)	EBI-22242478	0.35
M0R6T4	MMS19 nucleotide excision repair protein	EBI-22242478	0.35
Q3KRF2	High density lipoprotein binding protein (Vigilin) (High density lipoprotein binding protein, isoform CRA_c) (Vigilin)	EBI-22242478	0.35
Q5M963	N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase)	EBI-22242478	0.35
D3ZT90	Glutaryl-CoA dehydrogenase	EBI-22242478	0.35
Q8K1Q0	Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1)	EBI-22242478	0.35
Q6AYD5	G1 to S phase transition 1	EBI-22242478	0.35
Q9QZC5	Growth factor receptor-bound protein 7 (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)	EBI-22242478	0.35
P62083	40S ribosomal protein S7 (S8)	EBI-22242478	0.35
B2GV09	Llgl2 protein	EBI-22242478	0.35
B2RZ33	Cytoplasmic protein	EBI-22242478	0.35
D3ZD73	RNA helicase (EC 3.6.4.13)	EBI-22242478	0.35
M0R7K1	Protein lin-7 homolog	EBI-22242478	0.35
P62703	40S ribosomal protein S4, X isoform	EBI-22242478	0.35
G3V8S2	SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1)	EBI-22242478	0.35
Q9Z2M4	Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (EC 1.3.1.124) (2,4-dienoyl-CoA reductase 2) (DCR-AKL) (pVI-AKL)	EBI-22242478	0.35
Q66X93	Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (SND p102) (p100 co-activator) (p105 coactivator)	EBI-22242478	0.35
Q9WVK3	Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) (PX-2,4-DCR1) (Peroxisomal 2,4-dienoyl-CoA reductase) (RLF98)	EBI-22242478	0.35
Q8VID1	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (EC 1.1.1.300) (NADPH-dependent carbonyl reductase) (CR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (Short chain dehydrogenase/reductase family 25C member 2) (Protein SDR25C2)	EBI-22242478	0.35
P10860	Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (Memory-related gene 2 protein) (MRG-2)	EBI-22242478	0.35
P15651	Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)	EBI-22242478	0.35
P24666	Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)	EBI-25367578	0.37
P25098	Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)	EBI-25367534	0.37
P26038	Moesin (Membrane-organizing extension spike protein)	EBI-25367457	0.37
P63104	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)	EBI-25367490	0.37
Q15654	Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1)	EBI-25367468	0.37
Q96NW7	Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1)	EBI-25367523	0.37
P04075	Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)	EBI-25367688	0.37
O00170	AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9)	EBI-25367666	0.37
P09972	Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase)	EBI-25367699	0.37
Q13367	AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP)	EBI-25367710	0.37
Q02952	A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)	EBI-25367677	0.37
P84077	ADP-ribosylation factor 1 (EC 3.6.5.2)	EBI-25367732	0.37
P51693	Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]	EBI-25367721	0.37
Q7L266	Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]	EBI-25367754	0.37
P27449	V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)	EBI-25367765	0.37
Q12981	Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8)	EBI-25367776	0.37
Q96D05	Protein FAM241B	EBI-25367787	0.37
Q9UKR5	Ergosterol biosynthetic protein 28 homolog	EBI-25367798	0.37
Q96A57	Transmembrane protein 230	EBI-25367809	0.37
P57076	Cilia- and flagella-associated protein 298 (Protein kurly homolog)	EBI-25367820	0.37
Q8N5G0	Small integral membrane protein 20 (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa) (MITRAC7) [Cleaved into: Phoenixin-14 (PNX-14); Phoenixin-20 (PNX-20)]	EBI-25367831	0.37
P16152	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1)	EBI-25367842	0.37
Q9Y2S6	Translation machinery-associated protein 7 (Coiled-coil domain-containing protein 72)	EBI-25367853	0.37
P12277	Creatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B)	EBI-25367897	0.37
O75122	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2)	EBI-25367908	0.37
Q14055	Collagen alpha-2(IX) chain	EBI-25367919	0.37
Q14050	Collagen alpha-3(IX) chain	EBI-25367930	0.37
P52943	Cysteine-rich protein 2 (CRP-2) (Protein ESP1)	EBI-25367941	0.37
O75534	Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR)	EBI-25367952	0.37
P23528	Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)	EBI-25367886	0.37
Q9NYZ1	Golgi apparatus membrane protein TVP23 homolog B	EBI-25367974	0.37
P62942	Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)	EBI-25367985	0.37
Q00688	Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase)	EBI-25367996	0.37
P49368	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5)	EBI-25367864	0.37
Q8N111	Cell cycle exit and neuronal differentiation protein 1 (BM88 antigen)	EBI-25367875	0.37
P23677	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A)	EBI-25368128	0.37
Q7Z5L9	Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)	EBI-25368117	0.37
Q12906	Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)	EBI-25368106	0.37
P10809	60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)	EBI-25368095	0.37
P38646	Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)	EBI-25368084	0.37
P06396	Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)	EBI-25368073	0.37
Q13491	Neuronal membrane glycoprotein M6-b (M6b)	EBI-25368062	0.37
O76003	Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)	EBI-25368051	0.37
P60520	Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)	EBI-25368040	0.37
Q9H0R8	Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)	EBI-25368029	0.37
O75369	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	EBI-25368018	0.37
Q14318	Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)	EBI-25368007	0.55
Q9H9V9	2-oxoglutarate and iron-dependent oxygenase JMJD4 (EC 1.14.11.-) (JmjC domain-containing protein 4) (Jumonji domain-containing protein 4) (Lysyl-hydroxylase JMJD4)	EBI-25368150	0.37
Q07866	Kinesin light chain 1 (KLC 1)	EBI-25368172	0.37
Q8NC69	BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6)	EBI-25368161	0.37
Q9BRJ7	Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos)	EBI-25368260	0.37
Q9Y2I6	Ninein-like protein	EBI-25368249	0.37
Q643R3	Lysophospholipid acyltransferase LPCAT4 (1-acylglycerol-3-phosphate O-acyltransferase 7) (1-AGP acyltransferase 7) (1-AGPAT 7) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (1-alkenylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.121) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acyltransferase-like 3) (Lysophosphatidylcholine acyltransferase 4) (Lysophosphatidylethanolamine acyltransferase 2) (EC 2.3.1.n7) (Plasmalogen synthase)	EBI-25368194	0.37
B2RTY4	Unconventional myosin-IXa (Unconventional myosin-9a)	EBI-25368227	0.37
Q7L2J0	7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog)	EBI-25368216	0.37
P40925	Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)	EBI-25368205	0.37
O00214	Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)	EBI-25368183	0.37
Q14690	Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11)	EBI-25368293	0.37
P11940	Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)	EBI-25368282	0.37
Q9ULJ1	Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like)	EBI-25368271	0.37
P12036	Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)	EBI-25368238	0.37
P30086	Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]	EBI-25368304	0.37
P18669	Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B)	EBI-25368315	0.37
Q9Y237	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4)	EBI-25368326	0.37
Q14863	POU domain, class 6, transcription factor 1 (Brain-specific homeobox/POU domain protein 5) (Brain-5) (Brn-5) (mPOU homeobox protein)	EBI-25368337	0.37
P30044	Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)	EBI-25368359	0.37
P25786	Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)	EBI-25368370	0.37
P17980	26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)	EBI-25368381	0.37
P51148	Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)	EBI-25368392	0.37
Q6NTF9	Rhomboid domain-containing protein 2	EBI-25368414	0.37
Q8N4K4	Reprimo-like protein	EBI-25368425	0.37
Q15181	Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)	EBI-25368348	0.37
P31949	Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]	EBI-25368447	0.37
Q14151	Scaffold attachment factor B2 (SAF-B2)	EBI-25368458	0.37
Q9Y6D0	Selenoprotein K (SelK)	EBI-25368469	0.37
O43246	Cationic amino acid transporter 4 (CAT-4) (CAT4) (Solute carrier family 7 member 4)	EBI-25368480	0.37
Q9NQC3	Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)	EBI-25368436	0.37
O60641	Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)	EBI-25368502	0.37
P10451	Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)	EBI-25368513	0.37
P16949	Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)	EBI-25368524	0.37
Q9HCE3	Zinc finger protein 532	EBI-25368634	0.37
Q9ULU4	Protein kinase C-binding protein 1 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Rack7) (Zinc finger MYND domain-containing protein 8)	EBI-25368623	0.37
Q96NC0	Zinc finger matrin-type protein 2	EBI-25368612	0.37
Q8TCF1	AN1-type zinc finger protein 1 (Zinc finger AN1-type-containing protein 1)	EBI-25368601	0.37
P19971	Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)	EBI-25368590	0.37
P10599	Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)	EBI-25368579	0.37
Q8WW01	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	EBI-25368568	0.37
O15061	Synemin (Desmuslin)	EBI-25368546	0.37
P0DOF2	Matrix protein (Phosphoprotein M2)	EBI-25603126	0.35
Q96JA1	Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1)	EBI-25424141	0.75
Q6UXM1	Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)	EBI-25424266	0.35
P0DTD8	ORF7b protein (ORF7b) (Accessory protein 7b)	EBI-25687199	0.53
Q7TFA1	Protein non-structural 7b (ns7b) (Accessory protein 7b)	EBI-25688644	0.35
F1PAA9	Cadherin-1 (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	EBI-27079701	0.27
P63252	Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)	EBI-28956128	0.27
Q9BUF5	Tubulin beta-6 chain (Tubulin beta class V)	EBI-32718334	0.35
Q58FF8	Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb)	EBI-32718334	0.35
Q01813	ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)	EBI-32718334	0.35
Q9NNW5	WD repeat-containing protein 6	EBI-32718334	0.35
P05141	ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]	EBI-32718334	0.35
Q53GQ0	Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)	EBI-32718334	0.35
P00367	Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)	EBI-32718334	0.42
Q5T9A4	ATPase family AAA domain-containing protein 3B (AAA-TOB3)	EBI-32718334	0.35
P17858	ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)	EBI-32718334	0.35
A1L0T0	2-hydroxyacyl-CoA lyase 2 (EC 4.1.2.-) (Acetolactate synthase-like protein) (IlvB-like protein)	EBI-32718334	0.35
Q15293	Reticulocalbin-1	EBI-32718334	0.35
Q96EY1	DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)	EBI-32718334	0.35
Q9BSD7	Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase)	EBI-32718334	0.42
P13674	Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)	EBI-32718334	0.42
P13667	Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)	EBI-32718334	0.35
Q9H936	Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22)	EBI-32718334	0.35
P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)	EBI-32718334	0.35
Q9UBS4	DnaJ homolog subfamily B member 11 (APOBEC1-binding protein 2) (ABBP-2) (DnaJ protein homolog 9) (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (HEDJ) (Human DnaJ protein 9) (hDj-9) (PWP1-interacting protein 4)	EBI-32718334	0.35
Q9Y4W6	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)	EBI-32718334	0.42
O14967	Calmegin	EBI-32718334	0.35
Q9UBX3	Mitochondrial dicarboxylate carrier (DIC) (Solute carrier family 25 member 10)	EBI-32718334	0.35
Q5VV42	Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase)	EBI-32718334	0.35
P05067	Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]	EBI-32718334	0.35
Q8IV08	5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Phospholipase D3) (PLD 3)	EBI-32718334	0.35
Q9UET6	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1)	EBI-32718334	0.35
O43819	Protein SCO2 homolog, mitochondrial	EBI-32718334	0.35
Q9Y4L1	Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170)	EBI-32718334	0.42
O94905	Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)	EBI-32718334	0.35
Q5XKP0	MICOS complex subunit MIC13 (Protein P117)	EBI-32718334	0.35
P62158	Calmodulin-1	EBI-32718334	0.42
Q9NZ01	Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)	EBI-32718334	0.35
Q04837	Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17)	EBI-32718334	0.35
Q5K4L6	Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) (EC 6.2.1.-)	EBI-32718334	0.35
Q15072	Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146)	EBI-32718334	0.35
O15269	Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)	EBI-32718334	0.35
Q13308	Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)	EBI-32718334	0.35
P54709	Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)	EBI-32718334	0.35
Q9H3P7	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]	EBI-32721465	0.27
O95487	Protein transport protein Sec24B (SEC24-related protein B)	EBI-32721465	0.27
Q14141	Septin-6	EBI-32721465	0.27
Q96B97	SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)	EBI-32721465	0.27
O95757	Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)	EBI-32721465	0.27
O75410	Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)	EBI-32721465	0.27
P05198	Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)	EBI-32721465	0.27
Q15437	Protein transport protein Sec23B (hSec23B) (SEC23-related protein B)	EBI-32721465	0.27
P35241	Radixin	EBI-32721465	0.27
Q13643	Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2)	EBI-32721465	0.27
Q92599	Septin-8	EBI-32721465	0.27
Q9NSK0	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)	EBI-32721465	0.27
O60282	Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1)	EBI-32721465	0.27
P16333	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)	EBI-32721465	0.27
Q12774	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	EBI-32721465	0.27
Q96JB5	CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27)	EBI-32721465	0.27
O95486	Protein transport protein Sec24A (SEC24-related protein A)	EBI-32721465	0.27
Q13586	Stromal interaction molecule 1	EBI-32721465	0.27
P18085	ADP-ribosylation factor 4	EBI-32721465	0.27
P51648	Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Aldehyde dehydrogenase 10) (Fatty aldehyde dehydrogenase) (Microsomal aldehyde dehydrogenase)	EBI-32721465	0.27
Q9GZT9	Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)	EBI-32721465	0.27
Q9UKD2	mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4)	EBI-32721465	0.27
Q93008	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)	EBI-32721465	0.27
P09543	2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)	EBI-32721465	0.27
Q96PK6	RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein)	EBI-32721465	0.27
Q5JRA6	Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3)	EBI-32721465	0.27
P51659	Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]	EBI-32721465	0.27
O95433	Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38)	EBI-32721465	0.27
Q9Y5M8	Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1)	EBI-32721465	0.27
Q15717	ELAV-like protein 1 (Hu-antigen R) (HuR)	EBI-32721465	0.27
Q9H939	Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2)	EBI-32721465	0.27
P61088	Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)	EBI-32721465	0.27
Q92974	Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)	EBI-32721465	0.27
Q5VUB5	Protein FAM171A1 (Astroprincin) (APCN)	EBI-32721465	0.27
O94979	Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein)	EBI-32721465	0.27
Q9H9A6	Leucine-rich repeat-containing protein 40	EBI-32721465	0.27
O14745	Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)	EBI-32721465	0.27
Q13541	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	EBI-32721465	0.27
Q14126	Desmoglein-2 (Cadherin family member 5) (HDGC)	EBI-34582386	0.40

Cross-References

Database	Links
UNIPROT	P04626 B2RZG3 B4DHN3 Q14256 Q6LDV1 Q9UMK4 X5D2V5
PDB	1MFG 1MFL 1MW4 1N8Z 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 4NND 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6LBX 6OGE 7JXH 7MN5 7MN6 7MN8
Pfam	PF00757 PF14843 PF07714 PF01030
PROSITE	PS00107 PS50011 PS00109
OMIM	137800 164870 167000 211980 613659 619465
DisGeNET	2064

Receptor tyrosine-protein kinase erbB-2 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 1N8Z)

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Position in the Nuclear Envelope

Membrane Topology

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Database Associations

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (41 interactors)

Interactions with other proteins (452 interactors)

Cross-References

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Description

Description