Calcium-binding and coiled-coil domain-containing protein 2 - Homo sapiens

Calcium-binding and coiled-coil domain-containing protein 2 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Calcium-binding and coiled-coil domain-containing protein 2
Accession Code	Q13137
Gene	CALCOCO2
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 446)
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPID LNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELK DSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQ EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEII CNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPIC KADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL

Structure Viewer (PDB: 4XKL)

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:12869526, Experimental EvidencePubMed:17635994, Experimental EvidencePubMed:9230084}. Cytoplasm, cytoskeleton {Experimental EvidencePubMed:17635994}. Cytoplasmic vesicle, autophagosome membrane {Experimental EvidencePubMed:25771791}; Peripheral membrane protein {Curator Inference}. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. {Experimental EvidencePubMed:12869526, ECO:0000269\|PubMed:7540613, Experimental EvidencePubMed:9230084}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	Curator Inference {ECO:0000305}
Assigned Ontology terms

Cellular Component	Autophagosome (GO:0005776) Autophagosome Membrane (GO:0000421) Cytoplasm (GO:0005737) Cytoplasmic Vesicle (GO:0031410) Cytoskeleton (GO:0005856) Cytosol (GO:0005829) Intracellular Membrane-Bounded Organelle (GO:0043231) Membrane (GO:0016020) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) PML Body (GO:0016605)

Biology & Function

Description
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {Experimental EvidencePubMed:17635994, Experimental EvidencePubMed:22246324, Experimental EvidencePubMed:23022382, Experimental EvidencePubMed:23386746, Experimental EvidencePubMed:25771791}.
Assigned Ontology terms

Biological Process	Positive Regulation Of Autophagosome Maturation (GO:1901098) Response To Type II Interferon (GO:0034341) Viral Process (GO:0016032) Xenophagy (GO:0098792)
Molecular Function	Metal Ion Binding (GO:0046872) Protein Homodimerization Activity (GO:0042803)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (11 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O75604	Ubiquitin carboxyl-terminal hydrolase 2	EBI-24334992	0.56
O75716	Serine/threonine-protein kinase 16	EBI-10189253	0.56
P29991	RNA-directed RNA polymerase NS5	EBI-8829245	0.37
P50613	Cyclin-dependent kinase 7	EBI-21835901	0.35
Q02821	Importin subunit alpha	EBI-11534474	0.56
Q06787	Fragile X messenger ribonucleoprotein 1	EBI-6115370	0.55
Q13137	Self	EBI-758068	0.37
Q99IB8	RNA-directed RNA polymerase	EBI-6928172	0.37
Q9WMX2	RNA-directed RNA polymerase	EBI-9081202	0.57
Q96T37	RNA-binding protein 15	EBI-10293900	0.56
Q9H7C4	Syncoilin	EBI-21702482	0.35
Interactions with other proteins (218 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9Y3C5	RING finger protein 11	EBI-7220121	0.37
Q96S44	EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)	EBI-752485	0.74
O00214	Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)	EBI-752575	0.85
Q53FD0	Zinc finger C2HC domain-containing protein 1C	EBI-752725	0.37
Q8N715	Coiled-coil domain-containing protein 185	EBI-752740	0.37
Q8TBB1	E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)	EBI-753001	0.55
Q8N2W9	E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)	EBI-753673	0.37
Q8N5R6	Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61)	EBI-753856	0.37
P25786	Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)	EBI-753919	0.67
P26599	Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)	EBI-754081	0.37
Q3YEC7	Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1)	EBI-754117	0.37
Q9UBL6	Copine-7 (Copine VII)	EBI-24292126	0.56
Q96F93	ZNF101 protein	EBI-754906	0.37
Q9Y4Z0	U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)	EBI-754981	0.78
P29353	SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)	EBI-755236	0.55
P60520	Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)	EBI-755311	0.78
Q15906	Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1)	EBI-755386	0.37
Q9Y4E5	E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)	EBI-755704	0.37
Q9BQY9	Dysbindin domain-containing protein 2 (Casein kinase-1 binding protein) (CK1BP) (HSMNP1)	EBI-755827	0.37
Q14966	Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein)	EBI-755848	0.37
Q96D16	FBXL18 protein	EBI-755989	0.67
O95201	Zinc finger protein 205 (Zinc finger protein 210)	EBI-756364	0.37
P51116	RNA-binding protein FXR2 (FMR1 autosomal homolog 2)	EBI-756460	0.37
Q7L590	Protein MCM10 homolog (HsMCM10)	EBI-756649	0.37
Q9UNA4	DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B)	EBI-756718	0.37
Q9UKA9	Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein)	EBI-756841	0.37
O95251	Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)	EBI-757276	0.37
Q9BSM1	Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)	EBI-757711	0.37
P56279	T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)	EBI-757792	0.87
Q96GM5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit)	EBI-757918	0.67
Q8IYF1	Elongin-A2 (EloA2) (RNA polymerase II transcription factor SIII subunit A2) (Transcription elongation factor B polypeptide 3B)	EBI-757939	0.55
O14639	Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin)	EBI-757951	0.37
Q9H0I2	Enkurin domain-containing protein 1	EBI-758104	0.67
Q9BUY5	Zinc finger protein 426	EBI-758131	0.37
Q9BVV2	Fibronectin type III domain-containing protein 11	EBI-758146	0.67
P30626	Sorcin (22 kDa protein) (CP-22) (CP22) (V19)	EBI-758236	0.74
Q9BWD7	FASTK protein	EBI-758320	0.37
Q12933	TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)	EBI-758476	0.37
Q9H9D4	Zinc finger protein 408 (PR domain zinc finger protein 17)	EBI-758947	0.67
Q15038	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2) (Proline-rich transcript in brain protein)	EBI-759250	0.67
Q8TCX5	Rhophilin-1 (GTP-Rho-binding protein 1)	EBI-759364	0.37
Q9UBV8	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)	EBI-759700	0.67
Q9UBZ4	DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2)	EBI-759748	0.37
Q9H0R8	Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)	EBI-759847	0.78
O95990	Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A)	EBI-760045	0.37
Q7Z3B3	KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog)	EBI-760072	0.74
Q5NEX4	Dihydrolipoyl dehydrogenase (EC 1.8.1.4)	EBI-2808427	0.00
A0A3N4B896	Putative siderophore biosynthesis protein IucC	EBI-2840104	0.00
Q9UNI6	Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity tyrosine phosphatase YVH1)	EBI-8633706	0.74
Q15884	Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)	EBI-8636634	0.37
Q13671	Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)	EBI-8641704	0.67
Q8WUI4	Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)	EBI-10276459	0.56
Q99471	Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1)	EBI-8644653	0.67
Q6PF05	Tetratricopeptide repeat protein 23-like	EBI-8656859	0.37
Q86YD7	Protein FAM90A1	EBI-8656891	0.78
P01106	Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)	EBI-3962281	0.35
O43913	Origin recognition complex subunit 5	EBI-3935022	0.37
P15927	Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)	EBI-3935032	0.37
Q9Y4K3	TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)	EBI-3935052	0.37
Q9Y6K9	NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)	EBI-3935062	0.37
Q14161	ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)	EBI-3935072	0.37
Q8TDY2	RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)	EBI-3935082	0.37
Q15051	IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ)	EBI-4286917	0.35
Q7Z434	Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)	EBI-6115370	0.58
Q8NCU4	Coiled-coil domain-containing protein 191	EBI-6115370	0.35
Q9UHD2	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)	EBI-6115370	0.75
P48634	Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)	EBI-6115370	0.35
A7MCY6	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	EBI-6115370	0.53
Q9H6S1	5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP)	EBI-6115370	0.53
Q9NVV4	Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP)	EBI-6115370	0.50
Q9QYP6	5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1)	EBI-6115837	0.35
O41947	31 protein (Uncharacterized protein GAMMAHV.ORF31)	EBI-9640332	0.37
A8KA13	B-cell CLL/lymphoma 6, member B (Zinc finger protein), isoform CRA_a (cDNA FLJ16548 fis, clone PLACE7000410, highly similar to B-cell CLL/lymphoma 6 member B protein) (cDNA FLJ77637) (cDNA FLJ77701, highly similar to Homo sapiens B-cell CLL/lymphoma 6, member B (zinc finger protein)(BCL6B), mRNA)	EBI-10174899	0.56
Q2TBE0	CWF19-like protein 2	EBI-10175027	0.56
B2R9Y1	cDNA, FLJ94608, Homo sapiens reticulon 4 interacting protein 1 (RTN4IP1), mRNA	EBI-10175744	0.56
Q8WWY3	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31)	EBI-10177378	0.72
O00560	Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)	EBI-10180081	0.56
O43189	PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)	EBI-10183509	0.56
O43324	Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18)	EBI-10183831	0.56
O43602	Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)	EBI-10184475	0.56
O95363	Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)	EBI-10191564	0.78
P00540	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos)	EBI-10193294	0.78
P14678	Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B')	EBI-10198485	0.56
P17482	Homeobox protein Hox-B9 (Homeobox protein Hox-2.5) (Homeobox protein Hox-2E)	EBI-10199927	0.56
P25791	Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)	EBI-10202872	0.56
P26196	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)	EBI-10203823	0.72
P26640	Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS)	EBI-10204357	0.56
P32969	60S ribosomal protein L9 (Large ribosomal subunit protein uL6)	EBI-10206135	0.56
P41227	N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10)	EBI-10208549	0.78
P49901	Sperm mitochondrial-associated cysteine-rich protein	EBI-10211623	0.56
P50539	Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11)	EBI-10212007	0.72
P51946	Cyclin-H (MO15-associated protein) (p34) (p37)	EBI-10212597	0.56
P61968	LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)	EBI-10218982	0.56
P62979	Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a (Small ribosomal subunit protein eS31)]	EBI-10220080	0.56
Q02040	A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A)	EBI-10222670	0.56
Q05CH4	SLC15A3 protein	EBI-10223754	0.56
Q08117	TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)	EBI-10224979	0.56
Q12774	Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)	EBI-10227037	0.56
Q14997	Proteasome activator complex subunit 4 (Proteasome activator PA200)	EBI-10234580	0.56
Q14D33	Receptor-transporting protein 5 (3CxxC-type zinc finger protein 5) (CXXC-type zinc finger protein 11)	EBI-10234924	0.72
Q17RB8	LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191)	EBI-10238780	0.56
Q3B820	Protein FAM161A	EBI-10240301	0.72
Q5U5U6	Epididymis secretory protein Li 50 (Ubiquitin B) (Ubiquitin B, isoform CRA_a)	EBI-10247590	0.56
Q6NYC8	Phostensin (Protein phosphatase 1 F-actin cytoskeleton-targeting subunit) (Protein phosphatase 1 regulatory subunit 18)	EBI-10251814	0.56
Q6P4J0	N-terminal amino-acid N(alpha)-acetyltransferase NatA (EC 2.3.1.255)	EBI-10252829	0.56
Q6PIY7	Poly(A) RNA polymerase GLD2 (hGLD-2) (EC 2.7.7.19) (PAP-associated domain-containing protein 4) (Terminal nucleotidyltransferase 2) (Terminal uridylyltransferase 2) (TUTase 2)	EBI-10253897	0.56
Q7Z4I7	LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2)	EBI-10257703	0.56
Q86TG7	Retrotransposon-derived protein PEG10 (Embryonal carcinoma differentiation-regulated protein) (Mammalian retrotransposon-derived protein 2) (Myelin expression factor 3-like protein 1) (MEF3-like protein 1) (Paternally expressed gene 10 protein) (Retrotransposon gag domain-containing protein 3) (Retrotransposon-derived gag-like polyprotein) (Ty3/Gypsy-like protein)	EBI-10258559	0.67
Q86W54	Spermatogenesis-associated protein 24 (Testis protein T6441 homolog)	EBI-10259956	0.56
Q8IVS8	Glycerate kinase (EC 2.7.1.31) (HBeAg-binding protein 4)	EBI-10261677	0.56
Q8IYX8	Centrosomal protein CEP57L1 (Centrosomal protein 57kDa-like protein 1) (Centrosomal protein of 57 kDa-related protein) (Cep57R) (Cep57-related protein)	EBI-10264302	0.56
Q8N4T4	Rho guanine nucleotide exchange factor 39	EBI-10265711	0.67
Q8NBM4	Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1)	EBI-10269199	0.56
Q8TBE0	Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1)	EBI-10273199	0.56
Q8TBZ8	Zinc finger protein 564	EBI-10273829	0.56
Q8TES7	Fas-binding factor 1 (FBF-1) (Protein albatross)	EBI-10275340	0.56
Q8WU02	C9orf61 protein	EBI-10276217	0.56
Q8WXI9	Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)	EBI-10278009	0.56
Q92567	Protein FAM168A (Tongue cancer chemotherapy resistance-associated protein 1)	EBI-10278631	0.56
Q92608	Dedicator of cytokinesis protein 2	EBI-10278809	0.56
Q969Z0	FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4)	EBI-10281521	0.56
Q96A72	Protein mago nashi homolog 2	EBI-10281716	0.72
Q96BZ8	Leukocyte receptor cluster member 1	EBI-10282682	0.56
Q96C32	Polyubiquitin-C (UBC protein)	EBI-10283082	0.56
Q96D03	DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)	EBI-10284252	0.56
Q99732	Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)	EBI-10294748	0.72
Q9BU23	Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153)	EBI-10298573	0.56
Q9BV47	Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Low-molecular-mass dual-specificity phosphatase 4) (DSP-4) (LDP-4) (Mitogen-activated protein kinase phosphatase 8) (MAP kinase phosphatase 8) (MKP-8) (Novel amplified gene in thyroid anaplastic cancer)	EBI-10299234	0.56
Q9BXF9	Tektin-3	EBI-10301058	0.67
Q9BXY8	Protein BEX2 (Brain-expressed X-linked protein 2) (hBex2)	EBI-10301594	0.56
Q9H7H0	Methyltransferase-like protein 17, mitochondrial (EC 2.1.1.-) (False p73 target gene protein) (Methyltransferase 11 domain-containing protein 1) (Protein RSM22 homolog, mitochondrial)	EBI-10308833	0.78
Q9HC52	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	EBI-10310384	0.72
Q9NQT4	Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B)	EBI-10312366	0.56
Q9NU19	TBC1 domain family member 22B	EBI-10313689	0.56
Q9NX63	MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3)	EBI-10316161	0.56
Q9P0T4	Zinc finger protein 581	EBI-10317870	0.56
Q9P2K6	Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)	EBI-10318921	0.56
Q9UIM3	FK506-binding protein-like (WAF-1/CIP1 stabilizing protein 39) (WISp39)	EBI-10322118	0.56
Q9UJV3	Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)	EBI-10322427	0.56
Q9UJW0	Dynactin subunit 4 (Dyn4) (Dynactin subunit p62)	EBI-10322497	0.56
Q9UMS0	NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5)	EBI-10324153	0.56
Q9Y3M9	Zinc finger protein 337	EBI-10327900	0.56
Q9Y4X0	Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein)	EBI-10328456	0.67
P30566	Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)	EBI-21246927	0.37
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1)	EBI-21247102	0.37
X5DP31	Aryl-hydrocarbon receptor nuclear translocator 2 isoform E	EBI-21247566	0.37
X5D7R7	Major vault protein isoform G	EBI-21250303	0.37
X5DP17	Major vault protein isoform H	EBI-21250609	0.37
Q99608	Necdin	EBI-21250960	0.37
O43741	5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)	EBI-21251734	0.37
P03182	Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)	EBI-11721938	0.35
P30119	Uncharacterized protein BTRF1	EBI-11736591	0.37
P05759	Ubiquitin-40S ribosomal protein S31 [Cleaved into: Ubiquitin; 40S ribosomal protein S31 (CEP76) (S37) (Small ribosomal subunit protein eS31) (YS24)]	EBI-11522944	0.56
P0CH08	Ubiquitin-60S ribosomal protein L40 [Cleaved into: Ubiquitin; 60S ribosomal protein L40-A (CEP52) (Large ribosomal subunit protein eL40-A)]	EBI-11523121	0.56
P32902	37S ribosomal protein MRP4, mitochondrial (Mitochondrial small ribosomal subunit protein uS2m)	EBI-11526925	0.56
P38815	Endosomal/vacuolar adapter protein YPT35 (PX domain-containing protein YPT35)	EBI-11529521	0.56
P39518	Long-chain-fatty-acid--CoA ligase 2 (EC 6.2.1.3) (Fatty acid activator 2) (Long-chain acyl-CoA synthetase 2)	EBI-11529902	0.56
P40302	Proteasome subunit alpha type-6 (Macropain subunit PRE5) (Multicatalytic endopeptidase complex subunit PRE5) (Proteasome component PRE5) (Proteinase YSCE subunit PRE5)	EBI-11530551	0.56
P40325	Proline-rich protein HUA1	EBI-11530725	0.56
P41911	Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial (EC 1.1.1.8)	EBI-11531747	0.56
Q06630	Mitochondrial homologous recombination protein 1 (Cross-linked transcription component 1) (Mitochondrial large ribosomal subunit protein mL67)	EBI-11535826	0.56
Q06707	SWR1-complex protein 7	EBI-11535920	0.56
Q07821	Iron-sulfur assembly protein 1	EBI-11536127	0.56
Q12342	Protein LDB17 (Low dye-binding protein 17)	EBI-11537295	0.56
P28702	Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)	EBI-16433077	0.56
A0A0S2Z4M1	Axin-1 (Axis inhibition protein 1)	EBI-16433037	0.56
O15169	Axin-1 (Axis inhibition protein 1) (hAxin)	EBI-16433027	0.56
A0A0S2Z5X4	Zinc finger protein 688 isoform 4	EBI-16433137	0.56
Q3SY00	Testis-specific protein 10-interacting protein (Tsga10-interacting protein)	EBI-24288555	0.56
P57086	SCAN domain-containing protein 1	EBI-24289178	0.56
P47897	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	EBI-24292527	0.56
Q7L5A3	Protein FAM214B	EBI-24308054	0.56
Q5JVL4	EF-hand domain-containing protein 1 (Myoclonin-1)	EBI-24316916	0.56
P56524	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-24325092	0.56
Q9P1Z0	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1)	EBI-24331244	0.56
Q96HB5	Coiled-coil domain-containing protein 120	EBI-24332120	0.56
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)	EBI-24338182	0.56
Q9BSH4	Translational activator of cytochrome c oxidase 1 (Coiled-coil domain-containing protein 44) (Translational activator of mitochondrially-encoded cytochrome c oxidase I)	EBI-24338552	0.56
Q96FJ0	AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)	EBI-25243983	0.56
P51504	Zinc finger protein 80 (ZNFpT17)	EBI-24480415	0.56
Q8NE01	Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3)	EBI-24488458	0.56
Q8NA54	IQ and ubiquitin-like domain-containing protein	EBI-24496225	0.56
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16 (IL-16) (Lymphocyte chemoattractant factor) (LCF)]	EBI-24503792	0.56
Q96IQ9	Zinc finger protein 414	EBI-24507508	0.56
Q494U1	Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)	EBI-24374123	0.56
Q9BWG6	Sodium channel modifier 1	EBI-24383955	0.56
Q6NX45	Zinc finger protein 774	EBI-24388156	0.56
Q6VB84	Forkhead box protein D4-like 3 (FOXD4-like 3)	EBI-24390683	0.56
Q9C0A6	Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5)	EBI-24391757	0.56
O00311	Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)	EBI-24403310	0.56
P08218	Chymotrypsin-like elastase family member 2B (EC 3.4.21.71) (Elastase-2B)	EBI-24406407	0.56
P09067	Homeobox protein Hox-B5 (Homeobox protein HHO.C10) (Homeobox protein Hox-2A) (Homeobox protein Hu-1)	EBI-24427120	0.56
Q5T619	Zinc finger protein 648	EBI-24430220	0.56
Q9H7X3	Zinc finger protein 696	EBI-24432271	0.56
Q6PF15	Kelch-like protein 35	EBI-24453693	0.56
Q9BXW4	Microtubule-associated proteins 1A/1B light chain 3C (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (MAP1A/MAP1B light chain 3 C) (MAP1A/MAP1B LC3 C) (Microtubule-associated protein 1 light chain 3 gamma)	EBI-24455075	0.56
Q99633	Pre-mRNA-splicing factor 18 (PRP18 homolog) (hPRP18)	EBI-24456947	0.56
P28676	Grancalcin	EBI-24461986	0.56
Q6IQ23	Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)	EBI-16398399	0.35
Q53EZ4	Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6)	EBI-21572102	0.35
P0CG47	Polyubiquitin-B [Cleaved into: Ubiquitin]	EBI-21572102	0.35
Q3KP66	Innate immunity activator protein	EBI-21617875	0.35
Q9BU40	Chordin-like protein 1 (Neuralin-1) (Neurogenesin-1) (Ventroptin)	EBI-21739567	0.35
Q96DB2	Histone deacetylase 11 (HD11) (EC 3.5.1.98)	EBI-21787335	0.35
E9PKR8	Sulfotransferase (EC 2.8.2.-)	EBI-21872066	0.35
Q9UHQ4	B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29)	EBI-21883433	0.40
P29972	Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Urine water channel) (Water channel protein for red blood cells and kidney proximal tubule)	EBI-21268671	0.37
Q9H788	SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)	EBI-21268710	0.37
P15622	Zinc finger protein 250 (Zinc finger protein 647)	EBI-21268658	0.37
Q96HA8	Protein N-terminal glutamine amidohydrolase (EC 3.5.1.122) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (WDYHV motif-containing protein 1)	EBI-21268697	0.37
P61417	Chaperone protein YscY (Yop proteins translocation protein Y)	EBI-20817146	0.37
Q83DE4	Uncharacterized protein	EBI-21285435	0.37
P21580	Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37]	EBI-20737339	0.35
Q9UKE5	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)	EBI-28946906	0.55
Q14296	Fas-activated serine/threonine kinase (FAST kinase) (EC 2.7.11.1) (EC 2.7.11.8)	EBI-22127120	0.37
P0CG48	Polyubiquitin-C [Cleaved into: Ubiquitin]	EBI-22146758	0.37
Q92574	Hamartin (Tuberous sclerosis 1 protein)	EBI-26515497	0.37
Q8N612	FHF complex subunit HOOK interacting protein 1B (FHIP1B) (FTS and Hook-interacting protein) (FHIP)	EBI-34574737	0.27

Cross-References

Database	Links
UNIPROT	Q13137 B2RBT0 B4DDC4 B4DDT4 B4DP36 B4E0C0 E7ENK0 E7ETP5 E9PBE5 Q53FQ5 Q53HB5 Q6IBN9 Q9BTF7
PDB	2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L 7EAA
Pfam	PF17751
PROSITE	PS51905
OMIM	604587
DisGeNET	10241

Calcium-binding and coiled-coil domain-containing protein 2 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 4XKL)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

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Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (11 interactors)

Interactions with other proteins (218 interactors)

Cross-References

Database

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Description

Description