National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Equilibrative nucleoside transporter 2 |
| Accession Code | Q14542 |
| Gene | SLC29A2 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 456) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. |
| Nuclear Membrane | SL-0182 | The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {Experimental EvidencePubMed:9396714}. | Assigned Ontology terms |
Interactions with other proteins (2 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | Q14542 B3KPY7 O43530 Q52M84 Q96R00 Q9UPE0 |
| Pfam | PF01733 |
| OMIM | 602110 |
| DisGeNET | 3177 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory