NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Plasminogen activator inhibitor 1 RNA-binding protein - Rattus norvegicus - NucEnvDB

Plasminogen activator inhibitor 1 RNA-binding protein (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Plasminogen activator inhibitor 1 RNA-binding protein
Accession Code	Q6AXS5
Gene	Serbp1
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 407)
MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVADKKEETQPPVALKKEGIRRVGRRPDQQLQGDGKIIDRRPER RPPRERRFEKPLEEKGEGGEFSVDRPIIERPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNCSDLEQSNVTEETPE GEEHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKS SASAPDVDDPEAFPALA

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q8NC51}. Nucleus {By SimilarityUniProtKB:Q8NC51}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q8NC51}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation. {By SimilarityUniProtKB:Q8NC51}.
Assigned Ontology terms

Biological Process	PML Body Organization (GO:0030578) Regulation Of Apoptotic Process (GO:0042981)
Molecular Function	MRNA 3'-UTR Binding (GO:0003730) Ribosome Binding (GO:0043022) RNA Binding (GO:0003723) SUMO Binding (GO:0032183)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q96RT1	Erbin	EBI-22258042	0.35
Interactions with other proteins (8 interactors)

Partner (UniProt)		IntAct	Confidence score
P61980	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (dC stretch-binding protein) (CSBP)	EBI-931202	0.35
Q62976	Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog)	EBI-1638145	0.35
P35968	Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)	EBI-22252438	0.35
P43403	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)	EBI-22252989	0.35
P11274	Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)	EBI-22253187	0.35
P08575	Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)	EBI-22253598	0.35
P51692	Signal transducer and activator of transcription 5B	EBI-22257101	0.35
O75096	Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)	EBI-22258804	0.35

Cross-References

Database	Links
UNIPROT	Q6AXS5 Q8VHU3
Pfam	PF04774 PF16174

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