National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | 2-acylglycerol O-acyltransferase 3 |
| Accession Code | Q86VF5 |
| Gene | MOGAT3 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 341) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {Experimental EvidencePubMed:12618427, Experimental EvidencePubMed:27184406, Experimental EvidencePubMed:28420705}. | Assigned Ontology terms |
Interactions with other proteins (5 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | Q86VF5 Q496A6 Q496A7 Q496A8 Q9UDW7 |
| Pfam | PF03982 |
| OMIM | 610184 |
| DisGeNET | 346606 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory