NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Twinfilin-2 - Mus musculus - NucEnvDB

Twinfilin-2 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Twinfilin-2
Accession Code	Q9Z0P5
Gene	Twf2
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 349)
MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQG FEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRIN EVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPTNVAQLPSRIPRDAARYHFFL YKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFK QAFAKPKGPGGKRGHKRLIRGPGENGEDS

Structure Viewer (PDB: 7DS3)

Subcellular Location

Description
Cytoplasm, cytoskeleton {Experimental EvidencePubMed:19955359}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:10406962}. Cell projection, stereocilium {Experimental EvidencePubMed:19774077, Experimental EvidencePubMed:19955359}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. Isoform 2 found also along myofibrils in cardiomyocytes (PubMed:18837697). Localized in cochlea hair cells to the tips of the middle and short rows of stereocilia (PubMed:19955359). {ECO:0000269\|PubMed:18837697, Experimental EvidencePubMed:19955359}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Actin Filament (GO:0005884) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Filopodium (GO:0030175) Growth Cone (GO:0030426) Lamellipodium (GO:0030027) Myofibril (GO:0030016) Perinuclear Region Of Cytoplasm (GO:0048471) Stereocilium (GO:0032420)

Biology & Function

Description
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. {Experimental EvidencePubMed:18837697, Experimental EvidencePubMed:19955359}.
Assigned Ontology terms

Biological Process	Actin Filament Depolymerization (GO:0030042) Barbed-End Actin Filament Capping (GO:0051016) Cell Projection Organization (GO:0030030) Cellular Response To Growth Factor Stimulus (GO:0071363) Cellular Response To Retinoic Acid (GO:0071300) Intracellular Signal Transduction (GO:0035556) Negative Regulation Of Actin Filament Polymerization (GO:0030837) Positive Regulation Of Axon Extension (GO:0045773) Positive Regulation Of Lamellipodium Assembly (GO:0010592) Positive Regulation Of Neuron Projection Development (GO:0010976) Regulation Of Actin Cytoskeleton Organization (GO:0032956) Regulation Of Lamellipodium Assembly (GO:0010591) Regulation Of Microvillus Length (GO:0032532) Sequestering Of Actin Monomers (GO:0042989)
Molecular Function	Actin Filament Binding (GO:0051015) Actin Monomer Binding (GO:0003785) ATP Binding (GO:0005524) Phosphatidylinositol-4,5-Bisphosphate Binding (GO:0005546) Protein Kinase C Binding (GO:0005080)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P52927	High mobility group protein HMGI-C (High mobility group AT-hook protein 2)	EBI-9986179	0.35
Q93KQ6	Non-specific serine/threonine protein kinase (EC 2.7.11.1)	EBI-16142792	0.35

Cross-References

Database	Links
UNIPROT	Q9Z0P5 Q3TD06 Q3TZG2 Q8BN77 Q9DCK8
PDB	7DS3
Pfam	PF00241
PROSITE	PS51263

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