Hypoxia-inducible factor 1-alpha inhibitor - Homo sapiens

Hypoxia-inducible factor 1-alpha inhibitor (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Hypoxia-inducible factor 1-alpha inhibitor
Accession Code	Q9NWT6
Gene	HIF1AN
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 349)
MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEY LQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVM DFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMR NIEKMLGEALGNPQEVGPLLNTMIKGRYN

Structure Viewer (PDB: 6HL5)

Subcellular Location

Description
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nucleoplasm (GO:0005654) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {Experimental EvidencePubMed:12042299, Experimental EvidencePubMed:12080085, Experimental EvidencePubMed:17003112, Experimental EvidencePubMed:17573339, Experimental EvidencePubMed:18299578, Experimental EvidencePubMed:19245366, Experimental EvidencePubMed:21177872, Experimental EvidencePubMed:21251231}.
Assigned Ontology terms

Biological Process	Negative Regulation Of Notch Signaling Pathway (GO:0045746) Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia (GO:0061428) Obsolete Peptidyl-Asparagine Hydroxylation (GO:0042265) Peptidyl-Aspartic Acid Hydroxylation (GO:0042264) Peptidyl-Histidine Hydroxylation (GO:0036138) Positive Regulation Of Myoblast Differentiation (GO:0045663) Positive Regulation Of Vasculogenesis (GO:2001214)
Molecular Function	2-Oxoglutarate-Dependent Dioxygenase Activity (GO:0016706) Ankyrin Repeat Binding (GO:0071532) Carboxylic Acid Binding (GO:0031406) Ferrous Iron Binding (GO:0008198) NF-KappaB Binding (GO:0051059) Notch Binding (GO:0005112) Oxygen Sensor Activity (GO:0019826) [Protein]-Asparagine 3-Dioxygenase Activity (GO:0036140) Peptidyl-Histidine Dioxygenase Activity (GO:0036139) Protein Homodimerization Activity (GO:0042803) Zinc Ion Binding (GO:0008270)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (10 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O95271	Poly [ADP-ribose] polymerase tankyrase-1	EBI-8565753	0.78
P58546	Myotrophin	EBI-15602804	0.44
Q86UE4	Protein LYRIC	EBI-16813719	0.35
Q8WXH0	Nesprin-2	EBI-12502476	0.35
Q9H4L5	Oxysterol-binding protein-related protein 3	EBI-21638930	0.35
Q9NUQ3	Gamma-taxilin	EBI-21638930	0.35
Q9P0L0	Vesicle-associated membrane protein-associated protein A	EBI-12502476	0.35
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	EBI-15099018	0.75
O75190	DnaJ homolog subfamily B member 6	EBI-12502476	0.35
Q06787	Fragile X messenger ribonucleoprotein 1	EBI-12502476	0.35
Interactions with other proteins (204 interactors)

Partner (UniProt)		IntAct	Confidence score
Q96DX5	Ankyrin repeat and SOCS box protein 9 (ASB-9)	EBI-754615	0.78
Q8WXK3	Ankyrin repeat and SOCS box protein 13 (ASB-13)	EBI-755812	0.55
Q9Y283	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2)	EBI-759370	0.64
Q16665	Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)	EBI-1035055	0.92
Q6GQQ9	OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)	EBI-2510717	0.56
Q9H2K2	Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)	EBI-8565642	0.74
Q8TAK5	GA-binding protein subunit beta-2 (GABP subunit beta-2) (GABPB-2)	EBI-8565789	0.44
Q9HBA0	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)	EBI-8565771	0.44
Q8IY67	Ribonucleoprotein PTB-binding 1 (Protein raver-1)	EBI-12502476	0.35
P54132	RecQ-like DNA helicase BLM (EC 3.6.4.12) (Bloom syndrome protein) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)	EBI-12502476	0.35
Q8NB46	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52)	EBI-12502476	0.64
Q05823	2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L)	EBI-12502476	0.79
Q9NVH0	Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2)	EBI-12502476	0.35
Q9NWX5	Ankyrin repeat and SOCS box protein 6 (ASB-6)	EBI-12502476	0.53
Q68DC2	Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6)	EBI-12502476	0.35
Q9NU02	Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5)	EBI-12502476	0.35
O95218	Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) (Zinc finger, splicing)	EBI-12502476	0.35
Q969S3	Cytoplasmic 60S subunit biogenesis factor ZNF622 (Zinc finger protein 622) (Zinc finger-like protein 9)	EBI-12502476	0.35
Q8N5A5	Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)	EBI-12502476	0.35
Q9NUD5	Zinc finger CCHC domain-containing protein 3	EBI-12502476	0.35
Q8WYQ9	Zinc finger CCHC domain-containing protein 14 (BDG-29)	EBI-12502476	0.35
Q86T24	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33)	EBI-12502476	0.35
Q9BQA1	Methylosome protein 50 (MEP-50) (Androgen receptor cofactor p44) (WD repeat-containing protein 77) (p44/Mep50)	EBI-12502476	0.35
Q96MT7	Cilia- and flagella-associated protein 44 (WD repeat-containing protein 52)	EBI-12502476	0.35
Q14157	Ubiquitin-associated protein 2-like (Protein NICE-4)	EBI-12502476	0.35
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	EBI-12502476	0.35
Q9UM00	Calcium load-activated calcium channel (CLAC channel) (Transmembrane and coiled-coil domain-containing protein 1) (Transmembrane and coiled-coil domains protein 4) (Xenogeneic cross-immune protein PCIA3)	EBI-12502476	0.35
Q9Y4G6	Talin-2	EBI-12502476	0.35
Q99081	Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)	EBI-12502476	0.35
Q15370	Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2)	EBI-12502476	0.35
Q15369	Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1)	EBI-12502476	0.35
Q92844	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	EBI-12502476	0.35
Q9UNL2	Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma)	EBI-12502476	0.35
Q9Y2K2	Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK)	EBI-12502476	0.35
P60468	Protein transport protein Sec61 subunit beta	EBI-12502476	0.35
O43159	Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin)	EBI-12502476	0.35
P62847	40S ribosomal protein S24 (Small ribosomal subunit protein eS24)	EBI-12502476	0.35
P62841	40S ribosomal protein S15 (RIG protein) (Small ribosomal subunit protein uS19)	EBI-12502476	0.35
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	EBI-12502476	0.35
P61927	60S ribosomal protein L37 (G1.16) (Large ribosomal subunit protein eL37)	EBI-12502476	0.35
P61353	60S ribosomal protein L27 (Large ribosomal subunit protein eL27)	EBI-12502476	0.35
P57078	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)	EBI-12502476	0.50
Q7L0Y3	tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221)	EBI-12502476	0.35
Q04206	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)	EBI-12502476	0.35
Q9HCJ3	Ribonucleoprotein PTB-binding 2 (Protein raver-2)	EBI-12502476	0.35
Q2TAL8	Transcriptional regulator QRICH1 (Glutamine-rich protein 1)	EBI-12502476	0.35
O00487	26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1)	EBI-12502476	0.35
Q9UNM6	26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5)	EBI-12502476	0.35
O75832	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))	EBI-12502476	0.59
P62195	26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)	EBI-12502476	0.35
P35998	26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)	EBI-12502476	0.35
Q5H9R7	Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)	EBI-12502476	0.35
Q9UPN7	Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1)	EBI-12502476	0.35
O15355	Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)	EBI-12502476	0.35
P62875	DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)	EBI-12502476	0.35
P30876	DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2)	EBI-12502476	0.35
Q4KWH8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-1) (Phospholipase C-eta-1) (PLC-eta-1) (Phospholipase C-like protein 3) (PLC-L3)	EBI-12502476	0.35
O60733	85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9)	EBI-12502476	0.35
Q8IZ21	Phosphatase and actin regulator 4	EBI-12502476	0.35
P08237	ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)	EBI-12502476	0.35
Q8N3A8	Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8)	EBI-12502476	0.35
Q9BXW6	Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1)	EBI-12502476	0.53
Q9H857	5'-nucleotidase domain-containing protein 2 (EC 3.1.3.-)	EBI-12502476	0.35
Q9UM47	Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]	EBI-12502476	0.53
Q04721	Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]	EBI-12502476	0.35
Q9Y3T9	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor)	EBI-12502476	0.35
O00221	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)	EBI-12502476	0.35
P25963	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)	EBI-12502476	0.73
Q00653	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]	EBI-12502476	0.53
Q9P032	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa)	EBI-12502476	0.35
Q9Y6Q9	Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)	EBI-12502476	0.35
Q9HCH0	Nck-associated protein 5-like (NCKAP5-like) (Centrosomal protein of 169 kDa) (Cep169)	EBI-12502476	0.35
P41227	N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10)	EBI-12502476	0.35
Q9NZJ7	Mitochondrial carrier homolog 1 (Presenilin-associated protein)	EBI-12502476	0.35
Q8TE76	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4)	EBI-12502476	0.35
Q5TCX8	Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)	EBI-12502476	0.64
Q15773	Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2)	EBI-12502476	0.35
Q96AX9	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)	EBI-12502476	0.35
O43318	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)	EBI-12502476	0.35
Q7L5Y9	E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)	EBI-12502476	0.35
Q9BRK4	Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)	EBI-12502476	0.35
P83369	U7 snRNA-associated Sm-like protein LSm11	EBI-12502476	0.35
Q9ULH0	Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)	EBI-12502476	0.35
Q8N163	Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC)	EBI-12502476	0.35
Q7LBC6	Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B)	EBI-12502476	0.35
Q96SI1	BTB/POZ domain-containing protein KCTD15 (Potassium channel tetramerization domain-containing protein 15)	EBI-12502476	0.35
Q13418	Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)	EBI-12502476	0.59
Q12894	Interferon-related developmental regulator 2 (Protein SKMC15)	EBI-12502476	0.35
Q9ULT8	E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)	EBI-12502476	0.64
Q00341	Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)	EBI-12502476	0.35
O15379	Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)	EBI-12502476	0.35
Q9Y450	HBS1-like protein (ERFS)	EBI-12502476	0.35
Q9H6D7	HAUS augmin-like complex subunit 4	EBI-12502476	0.35
Q8IYU2	E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1)	EBI-12502476	0.35
Q9UKJ3	G patch domain-containing protein 8	EBI-12502476	0.35
O60547	GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)	EBI-12502476	0.53
Q9NRA8	Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)	EBI-12502476	0.53
P06730	Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)	EBI-12502476	0.35
Q9H9B1	Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)	EBI-12502476	0.35
Q96F86	Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1)	EBI-12502476	0.35
Q9Y678	Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)	EBI-12502476	0.35
A5YKK6	CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)	EBI-12502476	0.35
Q99439	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)	EBI-12502476	0.35
Q96ST8	Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123)	EBI-12502476	0.35
Q5VT06	Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa)	EBI-12502476	0.35
Q12834	Cell division cycle protein 20 homolog (p55CDC)	EBI-12502476	0.35
Q8WXE0	Caskin-2 (CASK-interacting protein 2)	EBI-12502476	0.35
Q9UKZ1	CCR4-NOT transcription complex subunit 11	EBI-12502476	0.35
Q9BY42	Replication termination factor 2 (RTF2) (Replication termination factor 2 domain-containing protein 1)	EBI-12502476	0.35
Q6ZUT1	Uncharacterized protein NKAPD1 (NKAP domain containing protein 1)	EBI-12502476	0.35
P20290	Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3)	EBI-12502476	0.35
Q9NVI7	ATPase family AAA domain-containing protein 3A	EBI-12502476	0.35
Q8NBU5	Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase)	EBI-12502476	0.35
Q9H765	Ankyrin repeat and SOCS box protein 8 (ASB-8)	EBI-12502476	0.64
P27540	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)	EBI-12502476	0.35
Q92625	Ankyrin repeat and SAM domain-containing protein 1A (Odin)	EBI-12502476	0.64
Q9ULJ7	Ankyrin repeat domain-containing protein 50	EBI-24286767	0.56
Q8N8A2	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44)	EBI-12502476	0.35
O15084	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK)	EBI-12502476	0.35
Q96NW4	Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)	EBI-12502476	0.53
O75179	Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16)	EBI-12502476	0.35
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK)	EBI-12502476	0.35
Q9P2R3	Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)	EBI-12502476	0.35
Q96FW1	Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)	EBI-10770028	0.70
P46531	Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]	EBI-11473706	0.44
P19838	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	EBI-11322417	0.74
P47086	Uncharacterized protein YJR011C	EBI-11532399	0.56
Q6P5F9	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)	EBI-11603310	0.35
Q6PG48	ANKRD12 protein	EBI-24615512	0.56
Q7Z713	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp)	EBI-24425210	0.56
Q9H672	Ankyrin repeat and SOCS box protein 7 (ASB-7)	EBI-24534882	0.56
Q8NFD2	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase)	EBI-25272595	0.67
Q96P71	N-terminal EF-hand calcium-binding protein 3 (Amyloid-beta A4 protein-binding family A member 2-binding protein) (Nek2-interacting protein 1) (Neuronal calcium-binding protein 3) (X11L-binding protein 51)	EBI-15098946	0.40
Q9Y575	Ankyrin repeat and SOCS box protein 3 (ASB-3)	EBI-21571836	0.35
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)	EBI-21638930	0.35
Q9UHD2	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)	EBI-21638930	0.35
Q9H6R7	WD repeat and coiled-coil-containing protein	EBI-21638930	0.35
Q9BQS8	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)	EBI-21638930	0.53
Q8WXD9	Caskin-1 (CASK-interacting protein 1)	EBI-21638930	0.35
Q8TES7	Fas-binding factor 1 (FBF-1) (Protein albatross)	EBI-21638930	0.35
Q8TBX8	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	EBI-21638930	0.35
Q15653	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)	EBI-21638930	0.53
Q05086	Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)	EBI-21638930	0.53
Q04864	Proto-oncogene c-Rel	EBI-21638930	0.35
Q01484	Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin)	EBI-21638930	0.35
P78356	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	EBI-21638930	0.53
P55196	Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)	EBI-21638930	0.35
P47974	mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)	EBI-21638930	0.35
P40222	Alpha-taxilin	EBI-21638930	0.53
Q12955	Ankyrin-3 (ANK-3) (Ankyrin-G)	EBI-21638930	0.35
Q8WXI3	Ankyrin repeat and SOCS box protein 10 (ASB-10)	EBI-21754620	0.35
Q9BW85	Splicing factor YJU2 (Coiled-coil domain-containing protein 94)	EBI-21758292	0.35
Q9Y574	Ankyrin repeat and SOCS box protein 4 (ASB-4)	EBI-21801297	0.35
Q8WVL7	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor)	EBI-21811862	0.69
Q3KP44	Ankyrin repeat domain-containing protein 55	EBI-21876401	0.35
Q96NS5	Ankyrin repeat and SOCS box protein 16 (ASB-16)	EBI-21897846	0.35
Q495B1	Ankyrin repeat and death domain-containing protein 1A	EBI-21900536	0.40
Q9UK73	Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)	EBI-15602843	0.59
Q9BZF9	Uveal autoantigen with coiled-coil domains and ankyrin repeats	EBI-15602883	0.51
Q06547	GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) (Nuclear respiratory factor 2) (Transcription factor E4TF1-47) (Transcription factor E4TF1-53)	EBI-15603005	0.44
P55273	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)	EBI-15603110	0.44
O14974	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)	EBI-15603359	0.44
Q9UL18	Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99)	EBI-16813719	0.35
P09012	U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)	EBI-16813719	0.35
O14497	AT-rich interactive domain-containing protein 1A (ARID domain-containing protein 1A) (B120) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A) (Osa homolog 1) (hOSA1) (SWI-like protein) (SWI/SNF complex protein p270) (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1) (hELD)	EBI-16813719	0.35
Q4U2R6	39S ribosomal protein L51, mitochondrial (L51mt) (MRP-L51) (Mitochondrial large ribosomal subunit protein mL51) (bMRP-64) (bMRP64)	EBI-16813719	0.35
Q9Y2X3	Nucleolar protein 58 (Nucleolar protein 5)	EBI-16813719	0.35
Q9Y2T7	Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog)	EBI-16813719	0.35
Q9UQ35	Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)	EBI-16813719	0.35
Q9H4B7	Tubulin beta-1 chain	EBI-16813719	0.35
Q9BWF3	RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)	EBI-16813719	0.35
Q9BVA1	Tubulin beta-2B chain	EBI-16813719	0.35
Q9BU76	Multiple myeloma tumor-associated protein 2 (hMMTAG2)	EBI-16813719	0.35
Q9BPZ3	Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2)	EBI-16813719	0.35
Q99700	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)	EBI-16813719	0.35
Q96MR6	Cilia- and flagella-associated protein 57 (WD repeat-containing protein 65)	EBI-16813719	0.35
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B)	EBI-16813719	0.35
Q92925	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B)	EBI-16813719	0.35
Q92784	Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4)	EBI-16813719	0.35
Q92734	Protein TFG (TRK-fused gene protein)	EBI-16813719	0.35
Q8WUZ0	B-cell CLL/lymphoma 7 protein family member C	EBI-16813719	0.35
Q8NFD5	AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R)	EBI-16813719	0.35
Q8N5F7	NF-kappa-B-activating protein	EBI-16813719	0.35
Q6PKG0	La-related protein 1 (La ribonucleoprotein domain family member 1)	EBI-16813719	0.35
Q4VC05	B-cell CLL/lymphoma 7 protein family member A	EBI-16813719	0.35
Q15020	Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)	EBI-16813719	0.35
Q13838	Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)	EBI-16813719	0.35
Q13283	Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)	EBI-16813719	0.35
Q13243	Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)	EBI-16813719	0.35
Q12926	ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Hel-N1)	EBI-16813719	0.35
Q07955	Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)	EBI-16813719	0.35
P82664	28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt) (Mitochondrial small ribosomal subunit protein uS10m)	EBI-16813719	0.35
P51531	Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)	EBI-16813719	0.35
P51532	Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)	EBI-16813719	0.35
Q9BQE3	Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]	EBI-16814752	0.53
Q7L014	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)	EBI-16814752	0.35
Q13772	Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1)	EBI-16814752	0.35
P48668	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)	EBI-16814752	0.35
Q969F8	KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (hOT7T175) (Hypogonadotropin-1) (Kisspeptins receptor) (Metastin receptor)	EBI-21282024	0.40
Q71UM5	40S ribosomal protein S27-like (Small ribosomal subunit protein eS27-like)	EBI-25479285	0.35
P50502	Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein)	EBI-25479285	0.35
Q9Y6H1	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP)	EBI-25479285	0.35
P40763	Signal transducer and activator of transcription 3 (Acute-phase response factor)	EBI-25485488	0.40
Q59H18	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)	EBI-28941654	0.35

Cross-References

Database	Links
UNIPROT	Q9NWT6 D3DR69 Q5W147 Q969Q7 Q9NPV5
PDB	1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6 6RUJ 7A1J 7A1K 7A1L 7A1M 7A1N 7A1O 7A1P 7A1Q 7A1S
Pfam	PF13621
PROSITE	PS51184
OMIM	606615
DisGeNET	55662

Hypoxia-inducible factor 1-alpha inhibitor (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 6HL5)

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Position in the Nuclear Envelope

Membrane Topology

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Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (10 interactors)

Interactions with other proteins (204 interactors)

Cross-References

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Description

Description