DnaJ homolog subfamily B member 6 - Homo sapiens

DnaJ homolog subfamily B member 6 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	DnaJ homolog subfamily B member 6
Accession Code	O75190
Gene	DNAJB6
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 326)
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGG SHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFEDFFGNRRGPRGSRSRGTGSFFSAFSGFPSFGSGFSSFDTG FTSFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKMVNGRKITTKRIVENGQERVEVEEDGQLKSLTINGVADDDALAE ERMRRGQNALPAQPAGLRPPKPPRPASLLRHAPHCLSEEEGEQDRPRAPGPWDPLASAAGLKEGGKRKKQKQREESKKKK STKGNH

Structure Viewer (PDB: 7JSQ)

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:10954706}. Nucleus {Experimental EvidencePubMed:10954706}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269\|PubMed:22366786}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Membrane (GO:0016020) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Z Disc (GO:0030018)

Biology & Function

Description
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. {Experimental EvidencePubMed:10954706, Experimental EvidencePubMed:11896048, Experimental EvidencePubMed:20159555, Experimental EvidencePubMed:22366786, Experimental EvidencePubMed:28233300}.
Assigned Ontology terms

Biological Process	Actin Cytoskeleton Organization (GO:0030036) Chaperone-Mediated Protein Folding (GO:0061077) Chorio-Allantoic Fusion (GO:0060710) Chorion Development (GO:0060717) Extracellular Matrix Organization (GO:0030198) Intermediate Filament Organization (GO:0045109) Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process (GO:0043154) Negative Regulation Of DNA-Templated Transcription (GO:0045892) Negative Regulation Of Inclusion Body Assembly (GO:0090084) Protein Folding (GO:0006457) Protein Localization To Nucleus (GO:0034504) Regulation Of Cellular Response To Heat (GO:1900034) Regulation Of Protein Localization (GO:0032880) Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development (GO:0060715)
Molecular Function	ATPase Activator Activity (GO:0001671) Chaperone Binding (GO:0051087) DNA Binding (GO:0003677) Heat Shock Protein Binding (GO:0031072) Identical Protein Binding (GO:0042802) Protein Folding Chaperone (GO:0044183) Unfolded Protein Binding (GO:0051082)

Disease associations

Description
Muscular dystrophy, limb-girdle, autosomal dominant 1 (LGMDD1) [MIM:603511]: An autosomal dominant myopathy characterized by adult onset of proximal muscle weakness, beginning in the hip girdle region and later progressing to the shoulder girdle region. {Experimental EvidencePubMed:22334415, Experimental EvidencePubMed:22366786}. Note=The disease is caused by variants affecting the gene represented in this entry. There is evidence that LGMDD1 is caused by dysfunction of isoform B (PubMed:22366786). {Experimental EvidencePubMed:22366786}.
Database Associations
OMIM	603511 611332
DisGeNET	10049

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (7 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P05783	Keratin, type I cytoskeletal 18	EBI-1255173	0.62
P04626	Receptor tyrosine-protein kinase erbB-2	EBI-8770853	0.35
Q9NWT6	Hypoxia-inducible factor 1-alpha inhibitor	EBI-12502476	0.35
O75190	Self	EBI-12593128	0.40
Q9Y605	MORF4 family-associated protein 1	EBI-25910113	0.56
Q99598	Translin-associated protein X	EBI-25909865	0.56
Q9Y224	RNA transcription, translation and transport factor protein	EBI-26615064	0.35
Interactions with other proteins (161 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9Y5J5	Pleckstrin homology-like domain family A member 3 (TDAG51/Ipl homolog 1)	EBI-1073616	0.00
Q15714	TSC22 domain family protein 1 (Cerebral protein 2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)	EBI-1082393	0.00
P01241	Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone)	EBI-1084628	0.00
Q9HCU9	Breast cancer metastasis-suppressor 1	EBI-1199948	0.51
P01106	Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)	EBI-1237540	0.35
P05787	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)	EBI-1255584	0.40
P11142	Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)	EBI-1255642	0.48
Q8AZK7	Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) (Epstein-Barr nuclear antigen 5) (EBNA-5) (EBV nuclear antigen 5)	EBI-9632715	0.53
P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)	EBI-2116670	0.00
Q8IY92	Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)	EBI-2371263	0.35
P0DPB6	DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19)	EBI-3941479	0.37
O75923	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1)	EBI-5357236	0.45
Q13326	Gamma-sarcoglycan (Gamma-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG)	EBI-5357396	0.45
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)	EBI-5656165	0.00
Q15327	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein)	EBI-5656148	0.00
P58340	Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1)	EBI-9360287	0.57
O75155	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2)	EBI-5656188	0.00
Q15773	Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2)	EBI-9360330	0.63
Q9UKD2	mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4)	EBI-5656239	0.00
Q00872	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)	EBI-5656274	0.00
P52179	Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1)	EBI-5656292	0.00
P36871	Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)	EBI-5656311	0.00
O75563	Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)	EBI-5656329	0.00
Q7KZ85	Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)	EBI-5656346	0.00
Q8WZ42	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)	EBI-5656363	0.00
Q96CW5	Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98)	EBI-5656400	0.00
Q13617	Cullin-2 (CUL-2)	EBI-21327106	0.35
Q13618	Cullin-3 (CUL-3)	EBI-21329068	0.35
Q96DB2	Histone deacetylase 11 (HD11) (EC 3.5.1.98)	EBI-6598272	0.35
Q9Y468	Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) (L3MBTL1)	EBI-8833199	0.53
Q13398	Zinc finger protein 211 (Zinc finger protein C2H2-25)	EBI-8837070	0.35
Q8K2C9	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1)	EBI-9360309	0.40
Q13200	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)	EBI-9360352	0.40
Q9BTE6	Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1)	EBI-9360374	0.40
Q99933	BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1)	EBI-9392988	0.35
O95816	BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)	EBI-9393030	0.35
O95817	BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)	EBI-9393075	0.35
O95429	BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains)	EBI-9393134	0.35
Q13451	Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)	EBI-9393873	0.35
Q96BE0	Heat shock protein family A (Hsp70) member 8b	EBI-9394503	0.35
P31948	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)	EBI-9395526	0.35
Q9UNE7	E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)	EBI-9395575	0.35
Q62925	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)	EBI-9971410	0.00
Q13404	Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)	EBI-9971410	0.00
P22314	Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)	EBI-9971410	0.00
P61088	Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)	EBI-9971410	0.00
Q16659	Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)	EBI-12502733	0.35
P57078	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)	EBI-12503575	0.35
Q6ZWV7	60S ribosomal protein L35	EBI-10997876	0.35
E9Q2H1	E3 ubiquitin-protein ligase UBR5	EBI-11033563	0.35
Q91YN9	BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)	EBI-11052510	0.35
P43243	Matrin-3	EBI-11071398	0.35
O55187	E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (E3 SUMO-protein transferase CBX4) (Polycomb 2 homolog) (Pc2) (mPc2)	EBI-11125708	0.35
P26447	Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)	EBI-11158347	0.35
Q5JU00	Dynein regulatory complex subunit 5 (T-complex-associated testis-expressed protein 1) (Tcte-1)	EBI-11367780	0.27
Q9UPV0	Centrosomal protein of 164 kDa (Cep164)	EBI-11379107	0.27
Q6P5F9	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)	EBI-11603310	0.35
Q9BW83	Intraflagellar transport protein 27 homolog (Putative GTP-binding protein RAY-like) (Rab-like protein 4)	EBI-12453281	0.35
Q71U36	Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	EBI-11897791	0.53
P03452	Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]	EBI-12577240	0.35
P03431	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)	EBI-12579142	0.35
P03428	Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)	EBI-12579909	0.35
I6T1Z2	Non-structural protein 1 (NS1)	EBI-12581764	0.35
Q5EP37	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)	EBI-12582596	0.35
C5E527	Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)	EBI-12585514	0.35
Q1K9H5	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)	EBI-12588098	0.35
B4URF7	Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)	EBI-12588729	0.35
Q9BY84	Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7)	EBI-14027455	0.35
Q8N5I9	NOP protein chaperone 1	EBI-21859350	0.35
P25686	DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)	EBI-21859350	0.35
Q6ZNJ1	Neurobeachin-like protein 2	EBI-16749633	0.35
Q86U44	N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70)	EBI-20594935	0.35
P10636	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	EBI-20799058	0.35
Q8TED1	Probable glutathione peroxidase 8 (GPx-8) (GSHPx-8) (EC 1.11.1.9)	EBI-20902320	0.40
A2A935	Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)	EBI-21022882	0.35
P14404	Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein homolog)	EBI-21026252	0.35
P54253	Ataxin-1 (Spinocerebellar ataxia type 1 protein)	EBI-21132804	0.35
P42858	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-25945964	0.56
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	EBI-22228108	0.40
Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5)	EBI-25409226	0.35
P0DOF2	Matrix protein (Phosphoprotein M2)	EBI-25603126	0.35
O95072	Meiotic recombination protein REC8 homolog (Cohesin Rec8p)	EBI-25483697	0.35
Q9IK92	Nucleoprotein (Protein N) (Nucleocapsid protein)	EBI-25747216	0.35
O43572	A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)	EBI-26451580	0.35
P15313	V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1)	EBI-25909736	0.56
O94778	Aquaporin-8 (AQP-8)	EBI-25909728	0.56
P09525	Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)	EBI-25909720	0.56
Q9NP70	Ameloblastin	EBI-25909712	0.56
P54687	Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (Protein ECA39)	EBI-25909745	0.56
Q8TD91	Melanoma-associated antigen C3 (Cancer/testis antigen 7.2) (CT7.2) (Hepatocellular carcinoma-associated antigen 2) (MAGE-C3 antigen)	EBI-25910153	0.56
P06276	Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase)	EBI-25909753	0.56
Q96QF0	Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein)	EBI-25910137	0.56
Q96CS2	HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) (Enhancer of invasion-cluster) (HEI-C)	EBI-25910129	0.56
Q9UII2	ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1)	EBI-25910121	0.56
Q86TI2	Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)	EBI-25910103	0.56
Q8WTV1	THAP domain-containing protein 3	EBI-25910095	0.56
Q8NHS9	Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)	EBI-25910087	0.56
Q9BRX9	WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)	EBI-25910079	0.56
Q96JB6	Lysyl oxidase homolog 4 (EC 1.4.3.-) (Lysyl oxidase-like protein 4) (Lysyl oxidase-related protein C)	EBI-25910069	0.56
Q9BQS8	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)	EBI-25910059	0.56
Q9BRX5	DNA replication complex GINS protein PSF3 (GINS complex subunit 3)	EBI-25910051	0.56
Q9H270	Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)	EBI-25910033	0.56
Q96LR2	Leucine rich adaptor protein 1 (Leucine repeat adapter protein 35A)	EBI-25910025	0.56
Q96FW1	Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)	EBI-25910017	0.56
Q96EN9	Required for excision 1-B domain-containing protein	EBI-25910001	0.56
Q9BUL9	Ribonuclease P protein subunit p25 (RNase P protein subunit p25)	EBI-25909993	0.56
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291)	EBI-25909975	0.56
Q9NNX6	CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209)	EBI-25909967	0.56
Q9H0W9	Ester hydrolase C11orf54 (EC 3.1.-.-)	EBI-25909959	0.56
Q9UBP4	Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)	EBI-25909951	0.56
Q9UH77	Kelch-like protein 3	EBI-25909941	0.56
Q6PID6	Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor)	EBI-25909933	0.56
Q96H20	Vacuolar-sorting protein SNF8 (ELL-associated protein of 30 kDa) (ESCRT-II complex subunit VPS22) (hVps22)	EBI-25909925	0.56
Q99871	HAUS augmin-like complex subunit 7 (26S proteasome-associated UCH37-interacting protein 1) (UCHL5-interacting protein) (X-linked protein STS1769)	EBI-25909915	0.56
Q8IXS7	SRGAP3 protein	EBI-25909907	0.56
Q9UJX2	Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)	EBI-25909897	0.56
Q14457	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]	EBI-25909889	0.56
O75558	Syntaxin-11	EBI-25909881	0.56
O15273	Telethonin (Titin cap protein)	EBI-25909873	0.56
Q12888	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	EBI-25909857	0.56
Q15293	Reticulocalbin-1	EBI-25909849	0.56
P30154	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)	EBI-25909841	0.56
I6L9F6	NEFL protein	EBI-25909833	0.56
Q13123	Protein Red (Cytokine IK) (IK factor) (Protein RER)	EBI-25909817	0.56
P80217	Interferon-induced 35 kDa protein (IFP 35) (Ifi-35)	EBI-25909809	0.56
H3BUJ7	Transcription factor E4F1	EBI-25909801	0.56
A0A024RCP2	Decapping nuclease (EC 3.6.1.-)	EBI-25909793	0.56
P53672	Beta-crystallin A2 (Beta-A2 crystallin)	EBI-25909785	0.56
P24310	Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)	EBI-25909777	0.56
Q13191	E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)	EBI-25909769	0.56
Q13887	Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)	EBI-25909761	0.56
Q6XD76	Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44)	EBI-25910145	0.56
Q6ZTN6	Ankyrin repeat domain-containing protein 13D	EBI-25910219	0.56
Q494V2	Cilia- and flagella-associated protein 100 (Coiled-coil domain-containing protein 37)	EBI-25910227	0.56
Q8NBB4	Zinc finger and SCAN domain-containing protein 1	EBI-25910203	0.56
Q6PJW8	Consortin	EBI-25910195	0.56
Q8N6F8	Methyltransferase-like protein 27 (Williams-Beuren syndrome chromosomal region 27 protein)	EBI-25910187	0.56
Q8NA54	IQ and ubiquitin-like domain-containing protein	EBI-25910179	0.56
Q6P1L5	Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein)	EBI-25910169	0.56
Q6P597	Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)	EBI-25910161	0.56
Q6NXT2	Histone H3.3C (Histone H3.5)	EBI-25910261	0.56
Q3KNS6	Zinc finger protein 829	EBI-25910243	0.56
Q7Z6I5	Spermatogenesis-associated protein 12 (Spermatogenesis-related protein 5)	EBI-25910235	0.56
Q8IV33	Uncharacterized protein KIAA0825	EBI-25910211	0.56
P48431	Transcription factor SOX-2	EBI-26574478	0.35
O60303	Katanin-interacting protein	EBI-26582514	0.35
Q8N488	RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)	EBI-27110926	0.35
P35226	Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)	EBI-27109494	0.35
P04049	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)	EBI-28931531	0.35
P22612	cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)	EBI-28934688	0.35
P80192	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1)	EBI-28938802	0.35
Q8IY84	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase)	EBI-28942464	0.35
Q8IWB6	Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein)	EBI-28942423	0.35
Q8NFD2	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase)	EBI-28943481	0.35
Q96D53	Atypical kinase COQ8B, mitochondrial (EC 2.7.-.-) (AarF domain-containing protein kinase 4) (Coenzyme Q protein 8B)	EBI-28944341	0.35
Q99558	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)	EBI-28944828	0.35
Q9NR20	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1)	EBI-28946409	0.35
Q9NSY0	Nuclear receptor-binding protein 2 (Transformation-related gene 16 protein) (TRG-16)	EBI-28946547	0.35
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3)	EBI-28946731	0.35
Q8NCK7	Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11)	EBI-27103180	0.35
Q05DH4	FHF complex subunit HOOK interacting protein 1A (FHIP1A) (FTS and Hook-interacting protein like) (FHIP-L)	EBI-34574576	0.27

Cross-References

Database	Links
UNIPROT	O75190 A4D232 A8K7D8 A8KAG0 B4DN73 E9PCZ2 O95806 Q53EN8 Q59EF2 Q6FIC8 Q75MA2 Q9UIK6
PDB	6U3R 6U3S 7JSQ 7QBY
Pfam	PF00226
PROSITE	PS00636 PS50076
OMIM	603511 611332
DisGeNET	10049

DnaJ homolog subfamily B member 6 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 7JSQ)

Subcellular Location

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Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

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Assigned Ontology terms

Disease associations

Description

Database Associations

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (7 interactors)

Interactions with other proteins (161 interactors)

Cross-References

Database

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Description

Description