Interactions with Nuclear Envelope proteins (8 interactors)
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Partner (NucEnvDB) IntAct Confidence score
P10415 Apoptosis regulator Bcl-2 EBI-2126646 0.44
P10909 Clusterin alpha chain EBI-4322676 0.61
P30429 Cell death protein 4 EBI-494146 0.40
Q07817 Self EBI-700842 0.59
Q64373 Bcl-2-like protein 1 EBI-700869 0.40
Q86Y07 Serine/threonine-protein kinase VRK2 EBI-6476114 0.50
P00519 Tyrosine-protein kinase ABL1 EBI-8488890 0.40
Q13625 Apoptosis-stimulating of p53 protein 2 EBI-15723914 0.56
Interactions with other proteins (104 interactors)
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Partner (UniProt) IntAct Confidence score
P49810 Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit] EBI-7072489 0.54
P49768 Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)] EBI-7072509 0.37
P70444 BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] EBI-15708450 0.44
Q92934 Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) EBI-7986686 0.97
O54918 Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) EBI-15616455 0.59
Q9NP97 Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) EBI-526396 0.35
P51572 B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) (6C6-AG tumor-associated antigen) (Protein CDM) (p28) EBI-78034 0.40
P45983 Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) EBI-7497515 0.52
Q14318 Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) EBI-7497660 0.44
Q07812 Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) EBI-701131 0.97
Q16611 Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) EBI-760384 0.95
O43521 Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death) EBI-701297 0.93
O00198 Activator of apoptosis harakiri (BH3-interacting domain-containing protein 3) (Neuronal death protein DP5) EBI-701309 0.70
Q9BXH1 Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis) EBI-707945 0.86
Q91ZE9 Bcl-2-modifying factor EBI-708056 0.44
Q13323 Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4) EBI-760279 0.91
P55957 BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] EBI-708176 0.86
Q61337 Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) EBI-709145 0.59
Q13794 Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa) EBI-709305 0.68
P02340 Cellular tumor antigen p53 (Tumor suppressor p53) EBI-728086 0.50
Q99ML1 Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis) EBI-728086 0.50
P04637 Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) EBI-727854 0.88
P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) EBI-1206864 0.00
P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) EBI-1207054 0.00
Q9C000 NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)] EBI-1246322 0.65
Q14457 Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] EBI-5234817 0.70
Q9H2V7 Protein spinster homolog 1 (HSpin1) (Spinster-like protein 1) EBI-1386556 0.46
O15304 Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) EBI-1393098 0.57
O35303 Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) EBI-1767441 0.40
O00429 Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1) EBI-1767523 0.44
A0A2S9PFE9 Proline-specific aminopeptidase (EC 3.4.11.9) EBI-2874931 0.00
O43889 Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)] EBI-8645414 0.37
P48558 Bax inhibitor 1 (BH3 domain-containing protein BXI1) EBI-5275391 0.40
P60709 Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] EBI-7102779 0.37
Q3B7T1 Erythroid differentiation-related factor 1 EBI-7102826 0.37
Q86XA0 Histone-arginine methyltransferase METTL23 (EC 2.1.1.319) (Methyltransferase-like protein 23) EBI-7102889 0.37
Q96N67 Dedicator of cytokinesis protein 7 EBI-7102942 0.37
P09467 Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase) EBI-7102996 0.37
Q9HC38 Glyoxalase domain-containing protein 4 EBI-7103053 0.37
Q6PKG0 La-related protein 1 (La ribonucleoprotein domain family member 1) EBI-7103101 0.37
P13667 Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) EBI-7103233 0.37
Q8IV08 5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Phospholipase D3) (PLD 3) EBI-7103438 0.37
Q8NEY8 Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50) EBI-7103564 0.37
P21246 Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1) EBI-7103628 0.37
P52756 RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) EBI-7103707 0.37
Q04724 Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) EBI-7103774 0.37
Q8IWV7 E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I) EBI-7103907 0.37
Q9HBF4 Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1) EBI-7103940 0.37
Q9UKY1 Zinc fingers and homeoboxes protein 1 EBI-7104013 0.37
Q9P2Y4 Zinc finger protein 219 EBI-7104091 0.37
Q96PU4 E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) EBI-6051471 0.40
P99999 Cytochrome c EBI-6589621 0.27
P04049 RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) EBI-6592472 0.27
P55211 Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] EBI-6593000 0.27
Q96LC9 Bcl-2-modifying factor EBI-10290553 0.81
Q61699 Heat shock protein 105 kDa (42 degrees C-HSP) (Heat shock 110 kDa protein) (Heat shock-related 100 kDa protein E7I) (HSP-E7I) EBI-11091301 0.35
P49286 Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor) EBI-11577578 0.00
Q7L3V2 Protein Bop (BH3-only protein) (Retrotransposon Gag-like protein 10) EBI-11509563 0.46
P03496 Non-structural protein 1 (NS1) (NS1A) EBI-11519828 0.37
Q20MH3 Non-structural protein 1 (NS1) EBI-11520043 0.37
Q0A2H0 Non-structural protein 1 (NS1) (NS1A) EBI-11520223 0.37
Q8NBJ4 Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) EBI-24661651 0.56
P56557 Transmembrane protein 50B (HCV p7-trans-regulated protein 3) EBI-24667028 0.56
Q9GZR5 Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) EBI-23702709 0.56
P22749 Granulysin (Lymphokine LAG-2) (Protein NKG5) (T-cell activation protein 519) EBI-24691348 0.56
Q7KZS0 Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) (Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast), isoform CRA_b) EBI-24702746 0.56
P27469 G0/G1 switch protein 2 (G0/G1 switch regulatory protein 2) (Putative lymphocyte G0/G1 switch gene) EBI-23766185 0.56
Q9Y282 Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84) EBI-24743336 0.56
Q9H2K0 Translation initiation factor IF-3, mitochondrial (IF-3(Mt)) (IF-3Mt) (IF3(mt)) (IF3mt) EBI-24748533 0.56
Q9H6H4 Receptor expression-enhancing protein 4 EBI-24749484 0.56
Q8IYJ2 Uncharacterized protein C10orf67, mitochondrial EBI-24779286 0.56
P78317 E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF) EBI-24796078 0.56
Q7Z5B4 Protein RIC-3 (Resistant to inhibitor of cholinesterase 3) EBI-23915698 0.56
P0C671 Protein BNIP5 EBI-24555838 0.56
Q6NTF9 Rhomboid domain-containing protein 2 EBI-24646649 0.56
Q5T7V8 RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (hNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) EBI-25269471 0.56
P24830 Regulatory protein E2 EBI-16046634 0.37
P06921 Regulatory protein E2 EBI-16047315 0.00
P06422 Regulatory protein E2 EBI-16048535 0.00
P36780 Regulatory protein E2 EBI-16049904 0.00
P04015 Regulatory protein E2 EBI-16050562 0.00
P06790 Regulatory protein E2 EBI-16051663 0.00
P06423 Regulatory protein E2 EBI-16052407 0.00
P03118 Regulatory protein E2 EBI-16053329 0.00
P36778 Regulatory protein E2 EBI-16054563 0.00
Q29RF7 Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112) EBI-21755538 0.35
Q99MI6 GTPase IMAP family member 3 (Immunity-associated nucleotide 4 protein) (IAN-4) EBI-15572392 0.56
Q8BWF2 GTPase IMAP family member 5 (GTPase of the immunity-associated protein 5) (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated protein 3) EBI-15572411 0.56
Q99104 Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) EBI-15666413 0.35
Q07813 Apoptosis regulator BAX EBI-15666413 0.53
Q8VDD5 Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) EBI-15666432 0.35
P42345 Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) EBI-15828862 0.69
P21796 Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) EBI-15828900 0.35
Q64010 Adapter molecule crk (Proto-oncogene c-Crk) (p38) EBI-15959690 0.40
O08734 Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) EBI-16176197 0.35
Q14790 Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] EBI-16211903 0.40
O15530 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1) EBI-16594603 0.35
P59637 Envelope small membrane protein (E protein) (sM protein) EBI-25487800 0.40
P59635 ORF7a protein (Accessory protein 7a) (Protein U122) (Protein X4) EBI-25494122 0.40
P37840 Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) EBI-25940857 0.56
Q9HB09 Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein) EBI-27086218 0.37
Q9H492 Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha) EBI-30828681 0.44
Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta) EBI-30830914 0.44
O75381 Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) EBI-30835456 0.44
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory