3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase - Homo sapiens

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Accession Code	Q15125
Gene	EBP
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 230)
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGTWRRLSLCWFAVCGFIHLVIE GWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVCMETITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIY GDVLYFLTEHRDGFQHGELGHPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN

Structure Viewer (PDB: 6OHU)

Subcellular Location

Description
Endoplasmic reticulum membrane {Experimental EvidencePubMed:10406945}; Multi-pass membrane protein {Curator Inference}. Nucleus envelope {Experimental EvidencePubMed:10406945}. Cytoplasmic vesicle {Experimental EvidencePubMed:10406945}. Note=During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles. {Experimental EvidencePubMed:10406945}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cytoplasmic Vesicle (GO:0031410) Endoplasmic Reticulum (GO:0005783) Endoplasmic Reticulum Membrane (GO:0005789) Obsolete Integral Component Of Endoplasmic Reticulum Membrane (GO:0030176) Nuclear Envelope (GO:0005635)

Biology & Function

Description
Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. {Experimental EvidencePubMed:12760743, Experimental EvidencePubMed:8798407, Experimental EvidencePubMed:9894009}.
Assigned Ontology terms

Biological Process	Cholesterol Biosynthetic Process (GO:0006695) Cholesterol Biosynthetic Process Via Desmosterol (GO:0033489) Cholesterol Biosynthetic Process Via Lathosterol (GO:0033490) Cholesterol Metabolic Process (GO:0008203) Hemopoiesis (GO:0030097) Ossification Involved In Bone Maturation (GO:0043931) Sterol Biosynthetic Process (GO:0016126)
Molecular Function	C-8 Sterol Isomerase Activity (GO:0000247) Cholestenol Delta-Isomerase Activity (GO:0047750) Identical Protein Binding (GO:0042802) Steroid Delta-Isomerase Activity (GO:0004769)

Disease associations

Description
Chondrodysplasia punctata 2, X-linked dominant (CDPX2) [MIM:302960]: A clinically and genetically heterogeneous disorder characterized by punctiform calcification of the bones. The key clinical features of CDPX2 are chondrodysplasia punctata, linear ichthyosis, cataracts and short stature. CDPX2 is a rare disorder of defective cholesterol biosynthesis, biochemically characterized by an increased amount of 8-dehydrocholesterol and cholest-8(9)-en-3-beta-ol in the plasma and tissues. {Experimental EvidencePubMed:10391218, Experimental EvidencePubMed:10391219, Experimental EvidencePubMed:10942423, Experimental EvidencePubMed:11493318, Experimental EvidencePubMed:18176751, Experimental EvidencePubMed:25814754}. Note=The disease is caused by variants affecting the gene represented in this entry. MEND syndrome (MEND) [MIM:300960]: An X-linked recessive disorder associated with a defect in sterol biosynthesis. Disease manifestations and severity are highly variable. Clinical features include intellectual disability, short stature, scoliosis, digital abnormalities, cataracts, and dermatologic abnormalities. {Experimental EvidencePubMed:12503101, Experimental EvidencePubMed:20949533, Experimental EvidencePubMed:24459067, Experimental EvidencePubMed:24700572}. Note=The disease is caused by variants affecting the gene represented in this entry.
Database Associations
OMIM	300205 300960 302960
DisGeNET	10682

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (18 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
A0A142I5B9	RNA-directed RNA polymerase NS5	EBI-20626314	0.35
A0PK00	Transmembrane protein 120B	EBI-24669908	0.56
P0DTD1	2'-O-methyltransferase nsp16	EBI-25686067	0.35
Q05397	Focal adhesion kinase 1	EBI-20903608	0.40
Q9WMX2	RNA-directed RNA polymerase	EBI-9083439	0.37
Q8IXM6	Nurim	EBI-22753239	0.56
Q9BXJ8	Ion channel TACAN	EBI-22754310	0.56
Q9NV29	Transmembrane protein 100	EBI-24695294	0.56
Q16873	Leukotriene C4 synthase	EBI-23732251	0.56
Q15125	Self	EBI-24723056	0.56
Q9P0L0	Vesicle-associated membrane protein-associated protein A	EBI-24733627	0.56
Q5BJF2	Sigma intracellular receptor 2	EBI-24740501	0.56
Q53HI1	Protein unc-50 homolog	EBI-23922913	0.56
Q96AG4	Leucine-rich repeat-containing protein 59, N-terminally processed	EBI-24548327	0.56
Q8IY26	Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6	EBI-24647840	0.56
Q5JX71	Protein FAM209A	EBI-24758742	0.56
Q8TD20	Solute carrier family 2, facilitated glucose transporter member 12	EBI-21562097	0.35
Q8N6S5	ADP-ribosylation factor-like protein 6-interacting protein 6	EBI-24694418	0.56
Interactions with other proteins (197 interactors)

Partner (UniProt)		IntAct	Confidence score
O75030	Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32)	EBI-3915259	0.37
Q9Z1B5	Mitotic spindle assembly checkpoint protein MAD2A (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1)	EBI-10996176	0.35
P14625	Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)	EBI-11044830	0.35
Q92542	Nicastrin	EBI-11046886	0.35
O75446	Histone deacetylase complex subunit SAP30 (30 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP30) (Sin3-associated polypeptide p30)	EBI-11060854	0.35
Q8BGH2	Sorting and assembly machinery component 50 homolog	EBI-11097023	0.35
Q9R0Q3	Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (Membrane protein p24A) (Sid 394) (p24 family protein beta-1) (p24beta1)	EBI-11111571	0.35
Q8K1S6	Protein spire homolog 2 (Spir-2)	EBI-11147685	0.35
Q6NUS6	Tectonic-3	EBI-11368748	0.27
Q96GX1	Tectonic-2	EBI-11375285	0.27
P49286	Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor)	EBI-11576336	0.37
P27105	Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)	EBI-12452286	0.51
Q5T700	Low-density lipoprotein receptor class A domain-containing protein 1	EBI-24310594	0.56
Q8WWP7	GTPase IMAP family member 1 (Immunity-associated protein 1) (hIMAP1)	EBI-24268159	0.56
P02724	Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a)	EBI-22752401	0.56
Q8IWU4	Zinc transporter 8 (ZnT-8) (Solute carrier family 30 member 8)	EBI-22754620	0.56
Q9BWM7	Sideroflexin-3	EBI-22754569	0.56
Q6UX98	Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 24)	EBI-24270634	0.56
O95167	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit)	EBI-24271223	0.56
P23141	Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cholesteryl ester hydrolase) (CEH) (EC 3.1.1.13) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)	EBI-22757994	0.56
Q08426	Peroxisomal bifunctional enzyme (PBE) (PBFE) (L-bifunctional protein) (LBP) (Multifunctional enzyme 1) (MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]	EBI-22758661	0.56
Q9NVC3	Putative sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7)	EBI-22759787	0.56
Q6P1K1	Heme transporter HRG1 (Heme-responsive gene 1 protein homolog) (HRG-1) (hHRG-1) (Solute carrier family 48 member 1)	EBI-22760233	0.56
Q9H2L4	Transmembrane protein 60	EBI-24272883	0.56
Q96G79	Probable UDP-sugar transporter protein SLC35A4 (Solute carrier family 35 member A4)	EBI-22760053	0.56
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1]	EBI-24631155	0.56
Q96GQ5	RUS family member 1	EBI-24659828	0.56
Q9NRX6	Protein kish-B (Transmembrane protein 167B)	EBI-24660186	0.56
Q3SXY8	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1)	EBI-23669642	0.56
Q9BU79	Transmembrane protein 243 (MDR1- and mitochondrial taxol resistance-associated protein) (MM-TRAG)	EBI-24661627	0.56
Q9NZG7	Ninjurin-2 (Nerve injury-induced protein 2)	EBI-24663072	0.56
P23763	Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1)	EBI-24664214	0.56
P63027	Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)	EBI-24667622	0.56
Q9Y385	Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)	EBI-24670704	0.56
P01031	Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]	EBI-23688881	0.56
A5PKU2	TUSC5 protein	EBI-24671905	0.56
Q13190	Syntaxin-5	EBI-24673341	0.56
Q96CP7	TLC domain-containing protein 1 (Calfacilitin)	EBI-24673683	0.56
O75396	Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)	EBI-24674462	0.56
B2RUZ4	Small integral membrane protein 1 (Vel blood group antigen)	EBI-24675325	0.56
O43759	Synaptogyrin-1	EBI-24676164	0.56
P81534	Beta-defensin 103 (Beta-defensin 3) (BD-3) (DEFB-3) (HBD3) (hBD-3) (Defensin, beta 103) (Defensin-like protein)	EBI-24677503	0.56
Q8TBM7	Transmembrane protein 254	EBI-24681654	0.56
O14653	Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)	EBI-24684144	0.56
P07204	Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)	EBI-24684847	0.56
Q8N2H4	Protein SYS1 homolog	EBI-24685442	0.56
Q9Y342	Plasmolipin (Plasma membrane proteolipid)	EBI-24686559	0.56
Q7Z4F1	Low-density lipoprotein receptor-related protein 10 (LRP-10)	EBI-23718808	0.56
P43378	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)	EBI-24688841	0.56
P17152	Transmembrane protein 11, mitochondrial (Protein PM1) (Protein PMI)	EBI-24690030	0.56
O95870	Phosphatidylserine lipase ABHD16A (EC 3.1.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) (hBAT5) (Monoacylglycerol lipase ABHD16A) (EC 3.1.1.23) (Protein G5)	EBI-24690968	0.56
Q96BZ9	TBC1 domain family member 20	EBI-24696326	0.56
P30519	Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form]	EBI-23733774	0.56
Q9NW97	Transmembrane protein 51	EBI-24698352	0.56
Q9Y6X1	Stress-associated endoplasmic reticulum protein 1 (Ribosome-attached membrane protein 4)	EBI-24698993	0.56
Q96LL9	DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein)	EBI-24699507	0.56
Q86Y82	Syntaxin-12	EBI-24702845	0.56
Q92982	Ninjurin-1 (Nerve injury-induced protein 1) [Cleaved into: Secreted ninjurin-1 (Soluble ninjurin-1)]	EBI-24703744	0.56
P49447	Transmembrane ascorbate-dependent reductase CYB561 (EC 7.2.1.-) (Cytochrome b-561) (Cytochrome b561)	EBI-24704221	0.56
Q8N2M4	Lysoplasmalogenase-like protein TMEM86A (Transmembrane protein 86A)	EBI-24706015	0.56
Q8N8N0	E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152)	EBI-24705925	0.56
Q8NBD8	Transmembrane protein 229B	EBI-24706316	0.56
Q8TD22	Sideroflexin-5	EBI-24707774	0.56
Q9UGM5	Fetuin-B (16G2) (Fetuin-like protein IRL685) (Gugu)	EBI-24708280	0.56
O75379	Vesicle-associated membrane protein 4 (VAMP-4)	EBI-24711580	0.56
Q9HD20	Endoplasmic reticulum transmembrane helix translocase (EC 7.4.2.-) (Endoplasmic reticulum P5A-ATPase)	EBI-24716721	0.56
Q8TDT2	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5)	EBI-24716697	0.56
Q969S6	Transmembrane protein 203	EBI-24716998	0.56
O95452	Gap junction beta-6 protein (Connexin-30) (Cx30)	EBI-24717966	0.56
Q6ZSS7	Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog)	EBI-24719764	0.56
Q96F15	GTPase IMAP family member 5 (Immune-associated nucleotide-binding protein 5) (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated nucleotide 5 protein) (IAN-5) (hIAN5) (Immunity-associated protein 3)	EBI-23774914	0.56
Q9Y282	Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Serologically defined breast cancer antigen NY-BR-84)	EBI-24721575	0.56
Q969E2	Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4)	EBI-24722338	0.56
Q9BZL3	Small integral membrane protein 3 (NGF-induced differentiation clone 67 protein) (Small membrane protein NID67)	EBI-24722570	0.56
Q9Y5Z9	UbiA prenyltransferase domain-containing protein 1 (EC 2.5.1.-) (Transitional epithelial response protein 1)	EBI-24725377	0.56
O15400	Syntaxin-7	EBI-23784204	0.56
O43169	Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform)	EBI-23784333	0.56
O14925	Mitochondrial import inner membrane translocase subunit Tim23	EBI-24728082	0.56
Q12983	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	EBI-24729517	0.56
Q15836	Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)	EBI-24730650	0.56
P50281	Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)	EBI-24732670	0.56
Q9BSR8	Protein YIPF4 (YIP1 family member 4)	EBI-24732968	0.56
Q9UNK0	Syntaxin-8	EBI-24732900	0.56
Q8N661	Lysoplasmalogenase (EC 3.3.2.2) (Transmembrane protein 86B)	EBI-24733842	0.56
Q13520	Aquaporin-6 (AQP-6) (Aquaporin-2-like) (Kidney-specific aquaporin) (hKID)	EBI-23803453	0.56
Q9NUH8	Transmembrane protein 14B	EBI-24740093	0.56
Q9NV12	Transmembrane protein 140	EBI-24747854	0.56
Q7Z5P4	17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 16C member 3) (Short-chain dehydrogenase/reductase 9)	EBI-23821019	0.56
Q9NRQ5	Single-pass membrane and coiled-coil domain-containing protein 4 (Protein FN5)	EBI-24750511	0.56
Q96EC8	Protein YIPF6 (YIP1 family member 6)	EBI-24751251	0.56
Q6PI78	Transmembrane protein 65	EBI-24752570	0.56
Q7L5A8	Fatty acid 2-hydroxylase (EC 1.14.18.-) (Fatty acid alpha-hydroxylase) (Fatty acid hydroxylase domain-containing protein 1)	EBI-24753438	0.56
Q8NHS1	Claudin domain-containing protein 2	EBI-24753392	0.56
Q9NWH2	Transmembrane protein 242	EBI-24756813	0.56
Q9NX14	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Neuronal protein 17.3) (Np17.3) (p17.3)	EBI-24756945	0.56
Q9BTX3	Transmembrane protein 208	EBI-24763251	0.56
P60033	CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)	EBI-24764608	0.56
Q9BVK8	Transmembrane protein 147 (Protein NIFIE 14)	EBI-24764734	0.56
Q9H1M4	Beta-defensin 127 (Beta-defensin 27) (DEFB-27) (Defensin, beta 127)	EBI-24765471	0.56
Q9UHE5	N-acetyltransferase 8 (EC 2.3.1.-) (Acetyltransferase 2) (ATase2) (Camello-like protein 1) (Cysteinyl-conjugate N-acetyltransferase) (CCNAT) (EC 2.3.1.80)	EBI-24765482	0.56
Q9P0S3	ORM1-like protein 1 (Adoplin-1)	EBI-24766077	0.56
Q9UKR5	Ergosterol biosynthetic protein 28 homolog	EBI-24767459	0.56
A2RU14	Transmembrane protein 218	EBI-24768914	0.56
Q68G75	LEM domain-containing protein 1 (Cancer/testis antigen 50) (CT50) (LEM domain protein 1) (LEMP-1)	EBI-24769184	0.56
Q86W74	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S)	EBI-24769830	0.56
Q9H2C2	Protein ARV1 (hARV1)	EBI-24779387	0.56
Q04941	Proteolipid protein 2 (Differentiation-dependent protein A4) (Intestinal membrane A4 protein)	EBI-24781694	0.56
Q9H1C4	Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1)	EBI-24782065	0.56
O95393	Bone morphogenetic protein 10 (BMP-10)	EBI-24782166	0.56
Q9Y5U4	Insulin-induced gene 2 protein (INSIG-2)	EBI-24782454	0.56
Q9H0R3	Transmembrane protein 222	EBI-24783086	0.56
O14523	Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24)	EBI-24783925	0.56
Q9NTJ5	Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein)	EBI-24784958	0.56
Q16617	Protein NKG7 (G-CSF-induced gene 1 protein) (GIG-1 protein) (Granule membrane protein of 17 kDa) (GMP-17) (Natural killer cell protein 7) (p15-TIA-1)	EBI-24785619	0.56
Q8WW34	Transmembrane protein 239	EBI-24786375	0.56
P61266	Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2)	EBI-24787698	0.56
Q9P0B6	Coiled-coil domain-containing protein 167	EBI-24795437	0.56
Q14318	Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)	EBI-24797367	0.56
Q96IV6	Fatty acid hydroxylase domain-containing protein 2	EBI-24797582	0.56
P25942	Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)	EBI-23911966	0.56
Q2M3R5	Solute carrier family 35 member G1 (Partner of STIM1) (Transmembrane protein 20)	EBI-25279560	0.56
Q9BV81	ER membrane protein complex subunit 6 (Transmembrane protein 93)	EBI-25282644	0.56
P08195	4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)	EBI-25283560	0.56
Q9Y548	Protein YIPF1 (YIP1 family member 1)	EBI-25283492	0.56
Q9BWH2	FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6)	EBI-25286529	0.56
Q07108	Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)	EBI-24594671	0.56
Q8N138	ORM1-like protein 3	EBI-24641145	0.56
Q8N511	Transmembrane protein 199	EBI-25145474	0.56
Q53FV1	ORM1-like protein 2 (Adoplin-2)	EBI-24641826	0.56
Q8NHW4	C-C motif chemokine 4-like (Lymphocyte activation gene 1 protein) (LAG-1) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Monocyte adherence-induced protein 5-alpha) (Small-inducible cytokine A4-like)	EBI-24642201	0.56
P15151	Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)	EBI-24644197	0.56
Q8WVV5	Butyrophilin subfamily 2 member A2	EBI-24646926	0.56
P54849	Epithelial membrane protein 1 (EMP-1) (CL-20) (Protein B4B) (Tumor-associated membrane protein)	EBI-24647331	0.56
Q9NSU2	Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (Deoxyribonuclease III) (DNase III)	EBI-24652174	0.56
Q99519	Sialidase-1 (EC 3.2.1.18) (Acetylneuraminyl hydrolase) (G9 sialidase) (Lysosomal sialidase) (N-acetyl-alpha-neuraminidase 1)	EBI-24652828	0.56
Q01453	Peripheral myelin protein 22 (PMP-22) (Growth arrest-specific protein 3) (GAS-3)	EBI-24654227	0.56
P55061	Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6)	EBI-24654827	0.56
Q8WVX3	Uncharacterized protein C4orf3 (Hepatitis C virus F protein-transactivated protein 1) (HCV F-transactivated protein 1)	EBI-24654804	0.56
Q9Y5U9	Immediate early response 3-interacting protein 1	EBI-24656328	0.56
Q6UX34	Protein SNORC (Secondary ossification center-associated regulator of chondrocyte maturation protein)	EBI-24657064	0.56
P57105	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25)	EBI-24659444	0.56
Q96JW4	Solute carrier family 41 member 2	EBI-24746616	0.56
Q5TGU0	Translocator protein 2 (Peripheral-type benzodiazepine receptor-like protein 1)	EBI-24762253	0.56
Q14802	FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3)	EBI-24774166	0.56
A0AVG3	t-SNARE domain containing 1 (t-SNARE domain-containing protein 1)	EBI-24776609	0.56
Q9NZ43	Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31)	EBI-24789687	0.56
Q7L5N7	Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkenylglycerophosphocholine O-acyltransferase) (EC 2.3.1.25) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha)	EBI-24790934	0.56
Q0VAQ4	Small cell adhesion glycoprotein (Small transmembrane and glycosylated protein)	EBI-24790824	0.56
Q96MV1	TLC domain-containing protein 4 (Transmembrane protein 56)	EBI-25203477	0.56
Q5J8X5	Membrane-spanning 4-domains subfamily A member 13 (Testis-expressed transmembrane protein 4)	EBI-24791226	0.56
Q8N6R1	Stress-associated endoplasmic reticulum protein 2 (Ribosome-associated membrane protein RAMP4-2)	EBI-25205775	0.56
O95070	Protein YIF1A (54TMp) (YIP1-interacting factor homolog A)	EBI-24799738	0.56
P54315	Inactive pancreatic lipase-related protein 1 (PL-RP1)	EBI-24800746	0.56
Q69YG0	Transmembrane protein 42	EBI-24801451	0.56
P29033	Gap junction beta-2 protein (Connexin-26) (Cx26)	EBI-24803571	0.56
Q9P0S9	Transmembrane protein 14C	EBI-25216661	0.56
Q6UWT4	Uncharacterized protein C5orf46	EBI-24806821	0.56
O95292	Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)	EBI-24808346	0.56
Q2M2E3	Outer dense fiber protein 4 (Outer dense fiber of sperm tails protein 4) (Testis-specific protein oppo 1) (hOPPO1)	EBI-25223826	0.56
O14735	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase)	EBI-24810822	0.56
Q9H9P2	Chondrolectin (Transmembrane protein MT75)	EBI-24810960	0.56
P06681	Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment]	EBI-25266575	0.56
O43752	Syntaxin-6	EBI-25266516	0.56
Q5QGT7	Receptor-transporting protein 2 (3CxxC-type zinc finger protein 2)	EBI-25268527	0.56
P78329	Cytochrome P450 4F2 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94) (Phylloquinone omega-hydroxylase CYP4F2) (EC 1.14.14.78)	EBI-25269159	0.56
Q8N5M9	Protein jagunal homolog 1	EBI-25270965	0.56
Q9H0Q3	FXYD domain-containing ion transport regulator 6 (Phosphohippolin)	EBI-25273560	0.56
O95159	Zinc finger protein-like 1 (Zinc finger protein MCG4)	EBI-25273227	0.56
Q9Y3D6	Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)	EBI-25274191	0.56
Q7RTS5	Proton channel OTOP3 (Otopetrin-3)	EBI-25274864	0.56
O43889	Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]	EBI-12701192	0.56
Q8IWL3	Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]	EBI-13943458	0.35
Q8IVT5	Kinase suppressor of Ras 1 (EC 2.7.11.1)	EBI-14035152	0.35
Q99679	Probable G-protein coupled receptor 21	EBI-21516430	0.35
P06028	Glycophorin-B (PAS-3) (SS-active sialoglycoprotein) (Sialoglycoprotein delta) (CD antigen CD235b)	EBI-21557067	0.35
P35414	Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)	EBI-21559824	0.35
P41587	Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2)	EBI-21567910	0.35
Q8NHX9	Two pore channel protein 2 (Two pore calcium channel protein 2)	EBI-21578009	0.35
O95274	Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4)	EBI-21607810	0.35
P32241	Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1)	EBI-21613594	0.35
Q9H244	P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999)	EBI-21614520	0.35
Q9H2J7	Sodium-dependent neutral amino acid transporter B(0)AT2 (Sodium- and chloride-dependent neurotransmitter transporter NTT73) (Sodium-coupled branched-chain amino-acid transporter 1) (Solute carrier family 6 member 15) (Transporter v7-3)	EBI-21614809	0.35
Q9ULW2	Frizzled-10 (Fz-10) (hFz10) (FzE7) (CD antigen CD350)	EBI-21704037	0.35
Q00765	Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)	EBI-21723128	0.35
P46098	5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)	EBI-21749232	0.35
Q96G97	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein)	EBI-21755399	0.35
P25101	Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR)	EBI-21755472	0.35
Q9Y2T5	G-protein coupled receptor 52	EBI-21760939	0.35
Q53R12	Transmembrane 4 L6 family member 20	EBI-21829296	0.35
P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)	EBI-21830586	0.40
Q8NHS3	Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7)	EBI-21887118	0.35
P05161	Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP)	EBI-16720078	0.35
P05067	Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]	EBI-20769256	0.37
Q12816	Trophinin (MAGE-D3 antigen)	EBI-20904848	0.40
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	EBI-21360986	0.35
P13569	Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)	EBI-25416349	0.35
Q5T9L3	Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)	EBI-22085230	0.49

Cross-References

Database	Links
UNIPROT	Q15125 Q6FGL3 Q6IBI9
PDB	6OHT 6OHU
PROSITE	PS51751
OMIM	300205 300960 302960
DisGeNET	10682

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 6OHU)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

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Assigned Ontology terms

Disease associations

Description

Database Associations

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (18 interactors)

Interactions with other proteins (197 interactors)

Cross-References

Database

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Description

Description