Nucleoporin p58/p45 - Homo sapiens

Nucleoporin p58/p45 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Nucleoporin p58/p45
Accession Code	Q9BVL2
Gene	NUP58
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 599)
MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGSKPATGFTLGG TNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTA TTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSK ALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELK NAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALA AQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGP QPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGI TASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR

Structure Viewer (PDB: 5IJN)

Subcellular Location

Description
Nucleus, nuclear pore complex {By SimilarityUniProtKB:P70581}. Nucleus membrane {By SimilarityUniProtKB:P70581}; Peripheral membrane protein {By SimilarityUniProtKB:P70581}; Cytoplasmic side {By SimilarityUniProtKB:P70581}. Nucleus membrane {By SimilarityUniProtKB:P70581}; Peripheral membrane protein {By SimilarityUniProtKB:P70581}; Nucleoplasmic side {By SimilarityUniProtKB:P70581}. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. {By SimilarityUniProtKB:P70581}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Nuclear Membrane	SL-0182	The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Nuclear Pore Complex	SL-0185	The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active bidirectional transport of macromolecules such as proteins, RNAs etc across the double-membrane nuclear envelope.The NPC is composed of at least 30 distinct subunits known as Nucleoporins (NUPs).
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:P70581}
Assigned Ontology terms

Cellular Component	Nuclear Envelope (GO:0005635) Nuclear Membrane (GO:0031965) Nuclear Pore (GO:0005643)

Biology & Function

Description
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {By SimilarityUniProtKB:P70581}.
Assigned Ontology terms

Biological Process	MRNA Transport (GO:0051028) Nucleocytoplasmic Transport (GO:0006913) Protein Transport (GO:0015031) Regulation Of Protein Import Into Nucleus (GO:0042306)
Molecular Function	Identical Protein Binding (GO:0042802) Nuclear Localization Sequence Binding (GO:0008139) Protein-Containing Complex Binding (GO:0044877) Structural Constituent Of Nuclear Pore (GO:0017056)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (19 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P0DTD1	2'-O-methyltransferase nsp16	EBI-25491191	0.53
P37198	Nuclear pore glycoprotein p62	EBI-8635195	0.80
P49792	E3 SUMO-protein ligase RanBP2	EBI-11077390	0.35
P52948	Nuclear pore complex protein Nup96	EBI-11077390	0.35
Q8N1F7	Nuclear pore complex protein Nup93	EBI-11077390	0.35
Q99598	Translin-associated protein X	EBI-25907995	0.56
Q9BZF3	Oxysterol-binding protein-related protein 6	EBI-21639380	0.35
P20749	B-cell lymphoma 3 protein	EBI-25907809	0.56
Q8WUX9	Charged multivesicular body protein 7	EBI-25908519	0.56
A1KXE4	Myelin-associated neurite-outgrowth inhibitor	EBI-25908575	0.56
O14770	Homeobox protein Meis2	EBI-24450131	0.56
Q9BTX1	Nucleoporin NDC1	EBI-11077390	0.35
P57740	Nuclear pore complex protein Nup107	EBI-11077390	0.35
Q5SRE5	Nucleoporin NUP188	EBI-11077390	0.35
Q92621	Nuclear pore complex protein Nup205	EBI-11077390	0.35
P35658	Nuclear pore complex protein Nup214	EBI-11077390	0.35
Q8NFH5	Nucleoporin NUP35	EBI-11077390	0.35
O15504	Nucleoporin NUP42	EBI-11077390	0.35
Q7Z3B4	Nucleoporin p54	EBI-10299822	0.92
Interactions with other proteins (129 interactors)

Partner (UniProt)		IntAct	Confidence score
A0A6L8PKS7	Methyl-accepting chemotaxis protein	EBI-2811590	0.00
P25054	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	EBI-3437349	0.00
Q9P2A4	ABI gene family member 3 (New molecule including SH3) (Nesh)	EBI-8635212	0.78
P27361	Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)	EBI-7201994	0.37
P42858	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-6451221	0.74
Q13077	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)	EBI-10299812	0.84
Q9UMX0	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)	EBI-10299842	0.56
Q99988	Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)	EBI-11077390	0.35
Q969P6	DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.6.2.1)	EBI-11077390	0.35
Q9BSD7	Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase)	EBI-11077390	0.35
P11532	Dystrophin	EBI-11077390	0.35
O15440	ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11)	EBI-11077390	0.35
Q96A73	Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa)	EBI-11077390	0.35
Q96BD5	PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)	EBI-11077390	0.35
Q14746	Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein)	EBI-11077390	0.35
Q9BPU9	B9 domain-containing protein 2 (MKS1-related protein 2)	EBI-11377507	0.27
Q96NL6	Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1)	EBI-11396361	0.27
Q96JB2	Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94)	EBI-24514268	0.72
Q7Z3Y7	Keratin, type I cytoskeletal 28 (Cytokeratin-28) (CK-28) (Keratin-25D) (K25D) (Keratin-28) (K28) (Type I inner root sheath-specific keratin-K25irs4)	EBI-24531449	0.56
Q9NYP9	Protein Mis18-alpha (FAPP1-associated protein 1)	EBI-24615263	0.72
O95994	Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)	EBI-24618865	0.56
Q96KN3	Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)	EBI-24406190	0.56
Q9Y2V7	Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6)	EBI-24474216	0.56
Q7Z3Y8	Keratin, type I cytoskeletal 27 (Cytokeratin-27) (CK-27) (Keratin-25C) (K25C) (Keratin-27) (K27) (Type I inner root sheath-specific keratin-K25irs3)	EBI-24474479	0.56
Q9UHD9	Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)	EBI-24475280	0.56
Q14525	Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II) (Keratin-33B) (K33B)	EBI-24599138	0.72
P55347	Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1)	EBI-24638583	0.72
Q96P53	WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22)	EBI-21607501	0.35
Q96A37	E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)	EBI-21627270	0.35
Q5VX52	Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2)	EBI-21635815	0.35
Q9NVF7	F-box only protein 28	EBI-21639380	0.35
Q9HD26	Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST)	EBI-21639380	0.35
Q96AX9	E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1)	EBI-21639380	0.35
Q15075	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2)	EBI-21639380	0.35
O75150	E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B)	EBI-21639380	0.35
Q9H1M0	Nucleoporin-62 C-terminal-like protein	EBI-21639380	0.35
Q96FN4	Copine-2 (Copine II)	EBI-21659658	0.35
O75830	Serpin I2 (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Pancreas-specific protein TSA2004) (Peptidase inhibitor 14) (PI-14)	EBI-20916376	0.40
Q9BYV2	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)	EBI-22024904	0.00
Q6P1K2	Polyamine-modulated factor 1 (PMF-1)	EBI-25907819	0.56
O75886	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)	EBI-25908093	0.56
Q99996	A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao)	EBI-25908085	0.56
O60636	Tetraspanin-2 (Tspan-2) (Tetraspan NET-3)	EBI-25908077	0.56
Q14154	DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1)]	EBI-25908069	0.56
Q6ZU52	Uncharacterized protein KIAA0408	EBI-25908059	0.56
A1A512	KIAA0355 protein	EBI-25908051	0.56
Q13503	Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)	EBI-25908043	0.56
Q52LW3	Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29)	EBI-25908035	0.56
O00303	Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)	EBI-25908027	0.56
Q92783	Signal transducing adapter molecule 1 (STAM-1)	EBI-25908019	0.56
Q8WUW1	Protein BRICK1 (BRK1)	EBI-25908011	0.56
P49459	Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)	EBI-25908003	0.56
Q86WV8	Hamartin (Tuberous sclerosis 1)	EBI-25907987	0.56
Q14765	Signal transducer and activator of transcription 4	EBI-25907979	0.56
Q96GM5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit)	EBI-25907971	0.56
P47804	RPE-retinal G protein-coupled receptor	EBI-25907963	0.56
P35998	26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)	EBI-25907955	0.56
Q9BR81	Protocadherin gamma subfamily C, 3 (Protocadherin gamma-C3)	EBI-25907939	0.56
Q13562	Neurogenic differentiation factor 1 (NeuroD) (NeuroD1) (Class A basic helix-loop-helix protein 3) (bHLHa3)	EBI-25907931	0.56
P02795	Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II)	EBI-25907923	0.56
P27338	Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B)	EBI-25907915	0.56
P80217	Interferon-induced 35 kDa protein (IFP 35) (Ifi-35)	EBI-25907899	0.56
Q06547	GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) (Nuclear respiratory factor 2) (Transcription factor E4TF1-47) (Transcription factor E4TF1-53)	EBI-25907891	0.56
O15287	Fanconi anemia group G protein (Protein FACG) (DNA repair protein XRCC9)	EBI-25907875	0.56
P41970	ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2)	EBI-25907867	0.56
H3BUJ7	Transcription factor E4F1	EBI-25907859	0.56
Q14117	Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase)	EBI-25907851	0.56
P24310	Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)	EBI-25907843	0.56
Q86WV5	CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog)	EBI-25907835	0.56
Q13887	Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)	EBI-25907827	0.56
Q9NP70	Ameloblastin	EBI-25907801	0.56
Q9BQS8	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)	EBI-25908407	0.56
O75934	Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)	EBI-25908101	0.56
Q9BV99	Leucine-rich repeat-containing protein 61	EBI-25908389	0.56
Q9BRX5	DNA replication complex GINS protein PSF3 (GINS complex subunit 3)	EBI-25908381	0.56
Q969X5	Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32)	EBI-25908373	0.56
Q6GQQ9	OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne)	EBI-25908363	0.56
Q9NS71	Gastrokine-1 (18 kDa antrum mucosa protein) (AMP-18) (Protein CA11)	EBI-25908355	0.56
Q9BXU0	Testis-expressed protein 12	EBI-25908347	0.56
Q96FT7	Acid-sensing ion channel 4 (ASIC4) (Amiloride-sensitive cation channel 4) (Amiloride-sensitive cation channel 4, pituitary)	EBI-25908331	0.56
Q96EP0	E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)	EBI-25908313	0.56
Q96EN9	Required for excision 1-B domain-containing protein	EBI-25908305	0.56
Q6NXG1	Epithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A)	EBI-25908297	0.56
Q9ULW8	Protein-arginine deiminase type-3 (EC 3.5.3.15) (Peptidylarginine deiminase III) (Protein-arginine deiminase type III)	EBI-25908271	0.56
Q8IXH7	Negative elongation factor C/D (NELF-C/D) (TH1-like protein)	EBI-25908263	0.56
P57682	Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2)	EBI-25908255	0.56
Q9BPZ3	Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2)	EBI-25908247	0.56
P57054	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P)	EBI-25908237	0.56
Q9BT78	COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)	EBI-25908229	0.56
Q9H347	Ubiquilin-3	EBI-25908221	0.56
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291)	EBI-25908211	0.56
Q9NNX6	CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209)	EBI-25908203	0.56
Q8N490	Probable hydrolase PNKD (EC 3.-.-.-) (Myofibrillogenesis regulator 1) (MR-1) (Paroxysmal nonkinesiogenic dyskinesia protein) (Trans-activated by hepatitis C virus core protein 2)	EBI-25908187	0.56
Q6PID6	Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor)	EBI-25908179	0.56
Q13352	Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)	EBI-25908169	0.56
Q8TBE0	Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1)	EBI-25908153	0.56
O43482	Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5)	EBI-25908145	0.56
O75935	Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22)	EBI-25908137	0.56
Q99871	HAUS augmin-like complex subunit 7 (26S proteasome-associated UCH37-interacting protein 1) (UCHL5-interacting protein) (X-linked protein STS1769)	EBI-25908127	0.56
O95229	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1)	EBI-25908119	0.56
O75528	Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein)	EBI-25908109	0.56
Q0VDD7	Break repair meiotic recombinase recruitment factor 1 (Pre-T/NK cell-associated protein 3B3)	EBI-25908397	0.56
Q86TI2	Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)	EBI-25908509	0.56
Q8IY31	Intraflagellar transport protein 20 homolog (hIFT20)	EBI-25908493	0.56
Q8NE08	COL25A1 protein	EBI-25908475	0.56
Q86U90	Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP)	EBI-25908417	0.56
Q9BV20	Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein)	EBI-25908459	0.56
Q8IUR5	Protein O-mannosyl-transferase TMTC1 (EC 2.4.1.109) (Transmembrane and TPR repeat-containing protein 1)	EBI-25908451	0.56
Q9H410	Kinetochore-associated protein DSN1 homolog	EBI-25908435	0.56
B7Z3E8	cDNA FLJ51208	EBI-25908427	0.56
Q96MW5	Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8)	EBI-25908467	0.56
A1L190	Synaptonemal complex central element protein 3 (Testis highly expressed gene 2 protein) (THEG-2)	EBI-25908655	0.56
Q6DKI2	Galectin-9C (Gal-9C) (Galectin-9-like protein B)	EBI-25908663	0.56
Q7Z6I5	Spermatogenesis-associated protein 12 (Spermatogenesis-related protein 5)	EBI-25908639	0.56
Q8IWT0	Protein archease (Protein ZBTB8OS) (Zinc finger and BTB domain-containing opposite strand protein 8)	EBI-25908631	0.56
P58304	Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)	EBI-25908623	0.56
Q8N6F8	Methyltransferase-like protein 27 (Williams-Beuren syndrome chromosomal region 27 protein)	EBI-25908615	0.56
Q6P597	Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)	EBI-25908607	0.56
Q86WT6	E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69)	EBI-25908599	0.56
Q96DX5	Ankyrin repeat and SOCS box protein 9 (ASB-9)	EBI-25908591	0.56
Q8NEZ2	Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1)	EBI-25908583	0.56
Q8NDH6	Islet cell autoantigen 1-like protein (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 14 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein)	EBI-25908567	0.56
Q6ZMI0	Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (KLRAQ motif-containing protein 1)	EBI-25908559	0.56
Q96A04	TSSK6-activating co-chaperone protein (SSTK-interacting protein) (SIP) (SSTK-IP)	EBI-25908551	0.56
Q96MN9	Zinc finger protein 488	EBI-25908543	0.56
Q96CS2	HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) (Enhancer of invasion-cluster) (HEI-C)	EBI-25908535	0.56
Q9UII2	ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1)	EBI-25908527	0.56
Q8N4C7	Syntaxin-19	EBI-25908647	0.56
Q93009	Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)	EBI-30844216	0.44

Cross-References

Database	Links
UNIPROT	Q9BVL2 A6NI12 B4DZJ1 O43160 Q5JRG2 Q5JRG5
PDB	4JO7 4JO9 4JQ5 5IJN 5IJO 7PER
OMIM	607615
DisGeNET	9818

Nucleoporin p58/p45 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 5IJN)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (19 interactors)

Interactions with other proteins (129 interactors)

Cross-References

Database

Links

Description

Description