Apoptosis-stimulating of p53 protein 2 - Homo sapiens

Apoptosis-stimulating of p53 protein 2 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Apoptosis-stimulating of p53 protein 2
Accession Code	Q13625
Gene	TP53BP2
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 1128)
MMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFL RHERPPGRDIVSGPRSQDPSLKRNGVKVPGEYRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQLLATKEQRLKFLK QQDQRQQQQVAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNNLFQQKQRELVLAVSKVEELTR QLEMLKNGRIDSHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQ QKENLPVSSDGNLPQQAASAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLVIQASEGPMKIQTLPNMRSGAASQ TKGSKIHPVGPDWSPSNADLFPSQGSASVPQSTGNALDQVDDGEVPLREKEKKVRPFSMFDAVDQSNAPPSFGTLRKNQS SEDILRDAQVANKNVAKVPPPVPTKPKQINLPYFGQTNQPPSDIKPDGSSQQLSTVVPSMGTKPKPAGQQPRVLLSPSIP SVGQDQTLSPGSKQESPPAAAVRPFTPQPSKDTLLPPFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTHTRGPH FSSVYGKPVIAAAQNQQQHPENIYSNSQGKPGSPEPETEPVSSVQENHENERIPRPLSPTKLLPFLSNPYRNQSDADLEA LRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSYPSKSASVTASSESPVEIQNPYLHVEPEKEV VSLVPESLSPEDVGNASTENSDMPAPSPGLDYEPEGVPDNSPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPE GPGEDSVSMRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGI TALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGY TQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRNLLGLYPRI KPRQRSLA

Structure Viewer (PDB: 4A63)

Subcellular Location

Description
Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cell Junction (GO:0030054) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {Experimental EvidencePubMed:11684014, Experimental EvidencePubMed:12524540, Experimental EvidencePubMed:12694406, Experimental EvidencePubMed:19377511}.
Assigned Ontology terms

Biological Process	Cell Cycle (GO:0007049) Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator (GO:0072332) Negative Regulation Of Cell Cycle (GO:0045786) Positive Regulation Of Execution Phase Of Apoptosis (GO:1900119) Signal Transduction (GO:0007165)
Molecular Function	Identical Protein Binding (GO:0042802) NF-KappaB Binding (GO:0051059) P53 Binding (GO:0002039) SH3 Domain Binding (GO:0017124)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (13 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P10415	Apoptosis regulator Bcl-2	EBI-15723849	0.65
P27958	RNA-directed RNA polymerase	EBI-9389968	0.64
P29991	RNA-directed RNA polymerase NS5	EBI-8828390	0.37
P49790	Nuclear pore complex protein Nup153	EBI-9688225	0.35
P61970	Nuclear transport factor 2	EBI-9688225	0.35
P62826	GTP-binding nuclear protein Ran	EBI-9692277	0.64
Q07817	Bcl-2-like protein 1	EBI-15723914	0.56
Q12840	Kinesin heavy chain isoform 5A	EBI-731035	0.00
Q13625	Self	EBI-7907803	0.62
Q9WMX2	RNA-directed RNA polymerase	EBI-9082105	0.37
Q9BUZ4	TNF receptor-associated factor 4	EBI-10299140	0.56
Q9UBU9	Nuclear RNA export factor 1	EBI-10319914	0.56
O95996	Adenomatous polyposis coli protein 2	EBI-8830464	0.54
Interactions with other proteins (122 interactors)

Partner (UniProt)		IntAct	Confidence score
P05067	Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]	EBI-77660	0.58
P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)	EBI-7267006	0.86
P68104	Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)	EBI-731032	0.00
P21246	Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1)	EBI-731038	0.00
Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16)	EBI-731041	0.00
Q13432	Protein unc-119 homolog A (Retinal protein 4) (hRG4)	EBI-731044	0.00
Q9BYC9	39S ribosomal protein L20, mitochondrial (L20mt) (MRP-L20) (Mitochondrial large ribosomal subunit protein bL20m)	EBI-733610	0.00
Q13107	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)	EBI-736082	0.00
O15265	Ataxin-7 (Spinocerebellar ataxia type 7 protein)	EBI-952468	0.00
P04637	Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)	EBI-1026207	0.90
P46937	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	EBI-6912563	0.78
P46936	Transcriptional coactivator YAP1 (Yes-associated protein 1) (65 kDa Yes-associated protein) (YAP65) (Protein yorkie homolog)	EBI-7804125	0.40
P63104	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)	EBI-7195756	0.67
P46108	Adapter molecule crk (Proto-oncogene c-Crk) (p38)	EBI-1960202	0.40
Q04917	14-3-3 protein eta (Protein AS1)	EBI-1644092	0.64
Q04206	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)	EBI-1749490	0.56
P35570	Insulin receptor substrate 1 (IRS-1) (pp185)	EBI-1751169	0.57
P81122	Insulin receptor substrate 2 (IRS-2) (4PS)	EBI-1751281	0.48
O08724	Insulin receptor substrate-3	EBI-1751296	0.35
O14654	Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)	EBI-1751296	0.35
P35569	Insulin receptor substrate 1 (IRS-1)	EBI-1751450	0.52
P36873	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)	EBI-7908028	0.85
Q92843	Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)	EBI-7908070	0.68
Q81ZG1	DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)])	EBI-2838000	0.00
Q14457	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]	EBI-3257986	0.35
P31016	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	EBI-7966630	0.44
Q09472	Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)	EBI-8632299	0.50
Q8IUQ4	E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)	EBI-10261292	0.56
P67870	Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)	EBI-7137665	0.37
Q13387	C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)	EBI-7240832	0.37
P53350	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)	EBI-7314465	0.37
Q8NEY8	Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50)	EBI-7317291	0.37
Q8TEW0	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	EBI-6911368	0.53
A6NKD9	Coiled-coil domain-containing protein 85C	EBI-6911368	0.35
P41236	Protein phosphatase inhibitor 2 (IPP-2)	EBI-6911368	0.35
O75901	Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor)	EBI-6911368	0.35
Q9H3G5	Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)	EBI-6911368	0.35
P34932	Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2)	EBI-6911368	0.35
P62140	Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)	EBI-6911368	0.67
Q8NHQ8	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)	EBI-6911368	0.53
Q92598	Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein)	EBI-6911368	0.35
Q02833	Ras association domain-containing protein 7 (HRAS1-related cluster protein 1)	EBI-6911368	0.35
Q15834	Coiled-coil domain-containing protein 85B (Hepatitis delta antigen-interacting protein A) (Delta-interacting protein A)	EBI-6911368	0.35
P04083	Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]	EBI-6911368	0.35
A6NK89	Ras association domain-containing protein 10	EBI-6912271	0.35
P31946	14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]	EBI-8796749	0.35
Q9Y2J4	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)	EBI-8797381	0.35
Q7TSJ6	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm)	EBI-8798662	0.27
Q4VCS5	Angiomotin	EBI-8799893	0.27
Q2TBE0	CWF19-like protein 2	EBI-10175037	0.56
Q8WWY3	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31)	EBI-10177388	0.56
O14777	Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)	EBI-10181501	0.56
P17031	Zinc finger protein 26 (Zinc finger protein KOX20)	EBI-10199685	0.56
P40222	Alpha-taxilin	EBI-10207929	0.56
P56279	T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)	EBI-10215275	0.56
P57075	Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)	EBI-10215824	0.56
P61968	LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)	EBI-10219004	0.56
P62807	Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)	EBI-10219796	0.56
P62875	DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)	EBI-10219932	0.56
P62993	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)	EBI-10220253	0.56
Q86Y26	NUT family member 1 (Nuclear protein in testis)	EBI-10230509	0.56
Q494U1	Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)	EBI-10241572	0.56
Q53HC0	Coiled-coil domain-containing protein 92 (Limkain beta-2)	EBI-10242635	0.56
Q8N5A5	Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)	EBI-10265979	0.56
Q8N5M1	ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog)	EBI-10266628	0.56
Q8NCE2	Myotubularin-related protein 14 (EC 3.1.3.-) (HCV NS5A-transactivated protein 4 splice variant A-binding protein 1) (NS5ATP4ABP1) (hJumpy)	EBI-10269256	0.56
Q92844	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	EBI-10279575	0.56
Q96DC9	Ubiquitin thioesterase OTUB2 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB2) (OTU domain-containing ubiquitin aldehyde-binding protein 2) (Otubain-2) (Ubiquitin-specific-processing protease OTUB2)	EBI-10284602	0.56
Q96GG9	DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)	EBI-10286368	0.56
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5)	EBI-10298924	0.56
Q9NU19	TBC1 domain family member 22B	EBI-10313701	0.56
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)	EBI-10324972	0.56
Q9Y2D8	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein)	EBI-10326054	0.56
Q96J02	E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)	EBI-10635597	0.40
Q9BYG5	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)	EBI-11002976	0.35
Q9NPB6	Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)	EBI-11011731	0.35
Q9JK83	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)	EBI-11052294	0.35
P46938	Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)	EBI-11138299	0.35
O75665	Centriole and centriolar satellite protein OFD1 (Oral-facial-digital syndrome 1 protein) (Protein 71-7A)	EBI-11365691	0.27
Q15154	Pericentriolar material 1 protein (PCM-1) (hPCM-1)	EBI-11366535	0.27
Q5BJF6	Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2)	EBI-11367291	0.27
Q5JU00	Dynein regulatory complex subunit 5 (T-complex-associated testis-expressed protein 1) (Tcte-1)	EBI-11367780	0.27
Q6ZU80	Centrosomal protein of 128 kDa (Cep128)	EBI-11370150	0.27
Q7Z7A1	Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110)	EBI-11371427	0.27
Q8N4C6	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein)	EBI-11374469	0.27
Q8TES7	Fas-binding factor 1 (FBF-1) (Protein albatross)	EBI-11374846	0.27
Q96KN7	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1)	EBI-11376202	0.27
Q96NL6	Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1)	EBI-11376636	0.27
Q96ST8	Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123)	EBI-11377220	0.27
Q9Y2I6	Ninein-like protein	EBI-11379511	0.27
O60308	Centrosomal protein of 104 kDa (Cep104)	EBI-11380299	0.27
O94986	Centrosomal protein of 152 kDa (Cep152)	EBI-11381405	0.27
Q5TB80	Centrosomal protein of 162 kDa (Cep162) (Protein QN1 homolog)	EBI-11385924	0.27
Q66GS9	Centrosomal protein of 135 kDa (Cep135) (Centrosomal protein 4)	EBI-11386281	0.27
Q68CZ1	Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein)	EBI-11386978	0.27
Q8IW35	Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2)	EBI-11391901	0.27
Q8N137	Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8)	EBI-11392655	0.27
Q8N960	Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100)	EBI-11393386	0.27
Q9C0F1	Centrosomal protein of 44 kDa (Cep44) (HBV PreS1-transactivated protein 3) (PS1TP3)	EBI-11397104	0.27
Q9HC77	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1)	EBI-11397411	0.27
Q15435	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)	EBI-12451625	0.51
O43295	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)	EBI-21563971	0.35
Q7Z4N8	Prolyl 4-hydroxylase subunit alpha-3 (4-PH alpha-3) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3)	EBI-21583801	0.35
Q86YM7	Homer protein homolog 1 (Homer-1)	EBI-21671273	0.35
Q9UMS4	Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)	EBI-21763056	0.35
Q96ES7	SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29)	EBI-21781962	0.35
Q96NE9	FERM domain-containing protein 6 (Willin)	EBI-21880697	0.35
P61981	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]	EBI-21905461	0.35
Q8N3R9	Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)	EBI-21911830	0.35
Q9H3D4	Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)	EBI-15685239	0.44
O15350	Tumor protein p73 (p53-like transcription factor) (p53-related protein)	EBI-15685344	0.44
P12830	Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	EBI-16124887	0.35
P35222	Catenin beta-1 (Beta-catenin)	EBI-16124887	0.58
Q05086	Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)	EBI-16814851	0.35
P16403	Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)	EBI-20919284	0.40
Q15149	Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)	EBI-20926194	0.40
Q9NPJ6	Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)	EBI-25472202	0.27
Q6NSK7	RIN3 protein	EBI-21387894	0.00
P0DOF2	Matrix protein (Phosphoprotein M2)	EBI-25603126	0.35
F1PAA9	Cadherin-1 (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	EBI-27079701	0.27
P46934	E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)	EBI-30832503	0.44
P11362	Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)	EBI-32721578	0.27

Cross-References

Database	Links
UNIPROT	Q13625 B4DG66 Q12892 Q86X75 Q96KQ3
PDB	1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Pfam	PF12796 PF00018
PROSITE	PS50297 PS50088 PS50002
OMIM	602143
DisGeNET	7159

Apoptosis-stimulating of p53 protein 2 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 4A63)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (13 interactors)

Interactions with other proteins (122 interactors)

Cross-References

Database

Links

Description

Description