COP9 signalosome complex subunit 6 - Homo sapiens

COP9 signalosome complex subunit 6 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	COP9 signalosome complex subunit 6
Accession Code	Q7L5N1
Gene	COPS6
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 327)
MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRN IEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKH TDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILE YVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGR RMRGLFF

Structure Viewer (PDB: 4D18)

Subcellular Location

Description
Nucleus {Experimental EvidencePubMed:9535219}. Cytoplasm {Experimental EvidencePubMed:9535219}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:9520381}. Note=(Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. {ECO:0000269\|PubMed:9520381}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	COP9 Signalosome (GO:0008180) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {Experimental EvidencePubMed:11285227, Experimental EvidencePubMed:11337588, Experimental EvidencePubMed:12628923, Experimental EvidencePubMed:12732143, Experimental EvidencePubMed:21625211, Experimental EvidencePubMed:9535219}.
Assigned Ontology terms

Biological Process	Protein Deneddylation (GO:0000338) Protein Neddylation (GO:0045116) Regulation Of Protein Neddylation (GO:2000434)
Molecular Function

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (14 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O75569	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	EBI-730597	0.00
P04406	Glyceraldehyde-3-phosphate dehydrogenase	EBI-21328549	0.35
P50402	Emerin	EBI-731797	0.00
P78406	mRNA export factor RAE1	EBI-21328549	0.35
Q3TLR7	Denticleless protein homolog	EBI-2562304	0.40
Q5JTH9	RRP12-like protein	EBI-21328549	0.35
Q9GZN7	Protein rogdi homolog	EBI-730002	0.00
Q9NZJ0	Denticleless protein homolog	EBI-2510262	0.56
Q9Y2M5	Kelch-like protein 20	EBI-2510262	0.40
Q8TEL6	Short transient receptor potential channel 4-associated protein	EBI-21332205	0.35
Q9UKA1	F-box/LRR-repeat protein 5	EBI-21796233	0.35
P11802	Cyclin-dependent kinase 4	EBI-21328549	0.35
P49454	Centromere protein F	EBI-21328549	0.35
Q92905	COP9 signalosome complex subunit 5	EBI-2510150	0.91
Interactions with other proteins (293 interactors)

Partner (UniProt)		IntAct	Confidence score
P40425	Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17)	EBI-348673	0.00
P08670	Vimentin	EBI-475271	0.37
P14174	Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)	EBI-7523063	0.40
Q9BX70	BTB/POZ domain-containing protein 2	EBI-2510262	0.75
Q96RU7	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)	EBI-729666	0.00
Q96HD1	Protein disulfide isomerase CRELD1 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 1)	EBI-729816	0.00
O43261	Leukemia-associated protein 1 (Deleted in lymphocytic leukemia 1) (HBV X-transactivated gene 6 protein) (HBV XAg-transactivated protein 6)	EBI-729873	0.00
Q3KQU3	MAP7 domain-containing protein 1 (Arginine/proline-rich coiled-coil domain-containing protein 1) (Proline/arginine-rich coiled-coil domain-containing protein 1)	EBI-729987	0.00
Q16363	Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha)	EBI-730249	0.00
Q15102	Platelet-activating factor acetylhydrolase IB subunit alpha1 (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)	EBI-730441	0.00
Q6P1K2	Polyamine-modulated factor 1 (PMF-1)	EBI-730531	0.00
O00231	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)	EBI-730615	0.00
P40937	Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)	EBI-730663	0.00
P15927	Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)	EBI-730690	0.00
P21673	Diamine acetyltransferase 1 (EC 2.3.1.57) (Polyamine N-acetyltransferase 1) (Putrescine acetyltransferase) (Spermidine/spermine N(1)-acetyltransferase 1) (SSAT) (SSAT-1)	EBI-730750	0.00
P50453	Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9)	EBI-730786	0.00
P62308	Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)	EBI-730870	0.00
P04183	Thymidine kinase, cytosolic (EC 2.7.1.21)	EBI-7396449	0.55
P17028	Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17)	EBI-731131	0.00
Q96SN7	Protein orai-2 (CAP-binding protein complex-interacting protein 2) (Transmembrane protein 142B)	EBI-731467	0.00
Q9Y6N8	Cadherin-10 (T2-cadherin)	EBI-731527	0.00
P42773	Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)	EBI-731554	0.00
Q14061	Cytochrome c oxidase copper chaperone	EBI-731602	0.00
P20674	Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)	EBI-731608	0.00
Q53FE4	Uncharacterized protein C4orf17	EBI-731683	0.00
O14717	tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet)	EBI-731731	0.00
P05305	Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1]	EBI-731764	0.00
Q09472	Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)	EBI-731824	0.00
P84090	Enhancer of rudimentary homolog	EBI-731839	0.00
Q9NY59	Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II)	EBI-731947	0.00
P30519	Heme oxygenase 2 (HO-2) (EC 1.14.14.18) [Cleaved into: Heme oxygenase 2 soluble form]	EBI-732133	0.00
Q9BWC9	Coiled-coil domain-containing protein 106	EBI-732208	0.00
P06858	Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32)	EBI-732383	0.00
Q13113	PDZK1-interacting protein 1 (17 kDa membrane-associated protein) (Protein DD96)	EBI-732452	0.00
Q8IYB7	DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-)	EBI-732497	0.00
Q8N2I9	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495)	EBI-732509	0.00
P51948	CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)	EBI-732533	0.00
Q99417	c-Myc-binding protein (Associate of Myc 1) (AMY-1)	EBI-732572	0.00
P09466	Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy-associated endometrial alpha-2 globulin) (PAEG) (PEG) (Progestagen-associated endometrial protein) (Progesterone-associated endometrial protein) (Zona-binding inhibitory factor-1) (ZIF-1)	EBI-732710	0.00
P17858	ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)	EBI-732806	0.00
Q92561	Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1)	EBI-732833	0.00
P07602	Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]	EBI-732965	0.00
P60484	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)	EBI-733013	0.00
Q9BXR0	Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase)	EBI-733043	0.00
P51159	Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)	EBI-733067	0.00
P11166	Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)	EBI-733325	0.00
Q16637	Survival motor neuron protein (Component of gems 1) (Gemin-1)	EBI-7388742	0.55
Q13190	Syntaxin-5	EBI-733412	0.00
P49888	Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (EST-1) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring)	EBI-733421	0.00
P13385	Teratocarcinoma-derived growth factor 1 (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1)	EBI-733511	0.00
O60315	Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)	EBI-733740	0.00
Q9Y4P8	WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2)	EBI-734305	0.00
P62861	FAU ubiquitin-like and ribosomal protein S30 [Cleaved into: Ubiquitin-like protein FUBI; 40S ribosomal protein S30 (Small ribosomal subunit protein eS30)]	EBI-734475	0.00
Q8IYL3	UPF0688 protein C1orf174	EBI-734959	0.00
P61313	60S ribosomal protein L15 (Large ribosomal subunit protein eL15)	EBI-21328549	0.55
P60903	Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)	EBI-735711	0.00
P05154	Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)	EBI-735763	0.00
P11230	Acetylcholine receptor subunit beta	EBI-736505	0.00
P23508	Colorectal mutant cancer protein (Protein MCC)	EBI-1064987	0.00
Q99816	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	EBI-2339285	0.37
Q15018	BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B)	EBI-8566862	0.35
Q9C0D3	Protein zyg-11 homolog B	EBI-2510262	0.40
Q6TFL4	Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1)	EBI-2510262	0.56
Q96SW2	Protein cereblon	EBI-2510262	0.67
Q9UNS2	COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)	EBI-2510262	0.88
Q96Q07	BTB/POZ domain-containing protein 9	EBI-2510262	0.56
Q15048	Leucine-rich repeat-containing protein 14	EBI-2510262	0.56
Q96EF6	F-box only protein 17 (F-box only protein 26)	EBI-2510262	0.67
Q13618	Cullin-3 (CUL-3)	EBI-2510262	0.56
Q96M94	Kelch-like protein 15	EBI-2510262	0.56
Q8WXC6	COP9 signalosome complex subunit 9 (CSN acidic protein) (CSNAP) (Myeloma-overexpressed gene 2 protein)	EBI-2510262	0.56
P15374	Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)	EBI-2510262	0.40
Q13616	Cullin-1 (CUL-1)	EBI-2510262	0.62
Q9UBW8	COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)	EBI-2510262	0.74
Q99627	COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)	EBI-2510262	0.85
Q8NEZ5	F-box only protein 22 (F-box protein FBX22p44)	EBI-2510262	0.40
Q9P2J3	Kelch-like protein 9	EBI-2510262	0.56
Q13619	Cullin-4A (CUL-4A)	EBI-2510262	0.74
Q9H078	Caseinolytic peptidase B protein homolog (EC 3.6.1.-) (Suppressor of potassium transport defect 3)	EBI-2510262	0.40
Q9H4M3	F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3)	EBI-2510262	0.56
Q9Y3I1	F-box only protein 7	EBI-2510262	0.67
Q13620	Cullin-4B (CUL-4B)	EBI-2510262	0.56
Q13617	Cullin-2 (CUL-2)	EBI-2510262	0.67
Q15369	Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1)	EBI-2510262	0.56
Q53GT1	Kelch-like protein 22	EBI-2510262	0.56
Q9UK73	Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)	EBI-2510262	0.67
B4DN30	cDNA FLJ52699, highly similar to WD repeat protein 21A	EBI-2510262	0.40
Q8TBC3	SH3KBP1-binding protein 1 (SETA-binding protein 1)	EBI-2510262	0.40
Q9H496	Torsin-1A-interacting protein 2, isoform IFRG15 (15 kDa interferon-responsive protein) (IFRG15)	EBI-2510262	0.56
Q8TEB1	DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23)	EBI-2510262	0.67
Q13309	S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)	EBI-2510262	0.67
Q9P2K6	Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)	EBI-2510262	0.56
Q13216	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)	EBI-2510262	0.56
Q86XK2	F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1)	EBI-2510262	0.56
Q92466	DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)	EBI-2510262	0.67
Q9BW61	DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1)	EBI-2510262	0.56
Q9BT78	COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)	EBI-2510262	0.88
Q647K1	Kelch-like 18	EBI-2510262	0.40
Q9P2G9	Kelch-like protein 8	EBI-2510262	0.56
Q9Y597	BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45)	EBI-2510262	0.40
Q9H9Q2	COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b)	EBI-2510262	0.74
P61201	COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)	EBI-2510262	0.81
Q96L50	Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5)	EBI-2510262	0.67
Q13098	COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)	EBI-2510262	0.86
Q9Y4B6	DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein)	EBI-2510262	0.56
Q9H0C5	BTB/POZ domain-containing protein 1 (Hepatitis C virus NS5A-transactivated protein 8) (HCV NS5A-transactivated protein 8)	EBI-2510262	0.67
P61024	Cyclin-dependent kinases regulatory subunit 1 (CKS-1)	EBI-2510262	0.56
Q5XUX1	F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9)	EBI-2510262	0.56
Q15843	NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)	EBI-2510262	0.56
Q9P2N7	Kelch-like protein 13 (BTB and kelch domain-containing protein 2)	EBI-2510262	0.56
Q93034	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)	EBI-2510262	0.56
P24386	Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein)	EBI-2515120	0.40
Q3U1J4	DNA damage-binding protein 1 (DDB p127 subunit) (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor)	EBI-2559059	0.40
A0A6L8PK65	Exopolyphosphatase (EC 3.6.1.11)	EBI-2835415	0.00
Q13573	SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)	EBI-7950968	0.35
Q9H3D4	Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)	EBI-3936407	0.37
P04083	Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]	EBI-7095166	0.37
P20073	Annexin A7 (Annexin VII) (Annexin-7) (Synexin)	EBI-7097023	0.37
P38936	Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)	EBI-7121191	0.37
Q16659	Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)	EBI-7206027	0.37
Q16644	MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)	EBI-7242276	0.37
P31947	14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)	EBI-5279534	0.65
Q8NHY2	E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)	EBI-5280877	0.52
Q9UBL3	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)	EBI-5654425	0.00
Q02556	Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)	EBI-6115692	0.35
P12520	Protein Vpr (R ORF protein) (Viral protein R)	EBI-6177205	0.35
Q96GG9	DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)	EBI-21325177	0.35
Q5VW00	DDB1- and CUL4-associated factor 12-like protein 2 (WD repeat-containing protein 40C)	EBI-21328549	0.35
O15061	Synemin (Desmuslin)	EBI-21328549	0.35
Q96ME1	F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18)	EBI-21328549	0.35
Q12951	Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead-related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HFH-3) (HNF-3/fork-head homolog 3)	EBI-21328549	0.35
Q9H469	F-box/LRR-repeat protein 15 (F-box only protein 37)	EBI-21328549	0.35
O94844	Rho-related BTB domain-containing protein 1	EBI-21328549	0.53
Q8N1E6	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)	EBI-21328549	0.53
P10599	Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)	EBI-21328549	0.35
Q9H4B7	Tubulin beta-1 chain	EBI-21328549	0.35
P68366	Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain)	EBI-21328549	0.35
Q01085	Nucleolysin TIAR (TIA-1-related protein)	EBI-21328549	0.35
O60506	Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)	EBI-21328549	0.35
P09234	U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C)	EBI-21328549	0.35
P08621	U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)	EBI-21328549	0.35
P05141	ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]	EBI-21328549	0.35
P31040	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)	EBI-21328549	0.35
P60866	40S ribosomal protein S20 (Small ribosomal subunit protein uS10)	EBI-21328549	0.35
P15880	40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) (Small ribosomal subunit protein uS5)	EBI-21328549	0.35
P62244	40S ribosomal protein S15a (Small ribosomal subunit protein uS8)	EBI-21328549	0.35
P62263	40S ribosomal protein S14 (Small ribosomal subunit protein uS11)	EBI-21328549	0.35
P05386	60S acidic ribosomal protein P1 (Large ribosomal subunit protein P1)	EBI-21328549	0.35
P62917	60S ribosomal protein L8 (Large ribosomal subunit protein uL2)	EBI-21328549	0.35
Q02878	60S ribosomal protein L6 (Large ribosomal subunit protein eL6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107)	EBI-21328549	0.35
P36578	60S ribosomal protein L4 (60S ribosomal protein L1) (Large ribosomal subunit protein uL4)	EBI-21328549	0.35
P62899	60S ribosomal protein L31 (Large ribosomal subunit protein eL31)	EBI-21328549	0.35
P83731	60S ribosomal protein L24 (60S ribosomal protein L30) (Large ribosomal subunit protein eL24)	EBI-21328549	0.35
P62829	60S ribosomal protein L23 (60S ribosomal protein L17) (Large ribosomal subunit protein uL14)	EBI-21328549	0.35
Q07020	60S ribosomal protein L18 (Large ribosomal subunit protein eL18)	EBI-21328549	0.35
Q06830	Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)	EBI-21328549	0.35
P13647	Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)	EBI-21328549	0.35
Q14568	Heat shock protein HSP 90-alpha A2 (Heat shock 90 kDa protein 1 alpha-like 3) (Heat shock protein HSP 90-alpha A2 pseudogene)	EBI-21328549	0.35
O14979	Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)	EBI-21328549	0.35
Q99729	Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)	EBI-21328549	0.35
P13639	Elongation factor 2 (EF-2)	EBI-21328549	0.35
P53675	Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22)	EBI-21328549	0.35
Q07021	Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)	EBI-21328549	0.35
P60709	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	EBI-21328549	0.35
P07437	Tubulin beta chain (Tubulin beta-5 chain)	EBI-21328549	0.35
Q9BQE3	Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]	EBI-21328549	0.35
Q92804	TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)	EBI-21328549	0.35
P62316	Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2)	EBI-21328549	0.35
P62701	40S ribosomal protein S4, X isoform (SCR10) (Single copy abundant mRNA protein) (Small ribosomal subunit protein eS4)	EBI-21328549	0.35
P05387	60S acidic ribosomal protein P2 (Large ribosomal subunit protein P2) (Renal carcinoma antigen NY-REN-44)	EBI-21328549	0.35
P62424	60S ribosomal protein L7a (Large ribosomal subunit protein eL8) (PLA-X polypeptide) (Surfeit locus protein 3)	EBI-21328549	0.35
P62913	60S ribosomal protein L11 (CLL-associated antigen KW-12) (Large ribosomal subunit protein uL5)	EBI-21328549	0.35
Q13610	Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502)	EBI-21328549	0.35
P11940	Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)	EBI-21328549	0.35
P06748	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)	EBI-21328549	0.35
P19838	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	EBI-21328549	0.35
P19338	Nucleolin (Protein C23)	EBI-21328549	0.35
O95678	Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)	EBI-21328549	0.35
P38646	Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)	EBI-21328549	0.35
P48741	Putative heat shock 70 kDa protein 7 (Heat shock 70 kDa protein B)	EBI-21328549	0.35
P11021	Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)	EBI-21328549	0.35
P52597	Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]	EBI-21328549	0.35
Q14103	Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)	EBI-21328549	0.35
Q05639	Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1)	EBI-21328549	0.35
P17844	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)	EBI-21328549	0.35
O00571	ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)	EBI-21328549	0.35
P61962	DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)	EBI-21328549	0.35
P68371	Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)	EBI-21328549	0.35
Q9Y3Z3	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)	EBI-21328549	0.35
P63173	60S ribosomal protein L38 (Large ribosomal subunit protein eL38)	EBI-21328549	0.35
P36639	Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1)	EBI-21328549	0.35
P34931	Heat shock 70 kDa protein 1-like (Heat shock 70 kDa protein 1L) (Heat shock 70 kDa protein 1-Hom) (HSP70-Hom)	EBI-21328549	0.35
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5)	EBI-21328549	0.35
P31942	Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9)	EBI-21328549	0.35
P31943	Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]	EBI-21328549	0.35
P22626	Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)	EBI-21328549	0.35
P62280	40S ribosomal protein S11 (Small ribosomal subunit protein uS17)	EBI-21328549	0.35
P61626	Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)	EBI-21328549	0.35
Q01546	Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)	EBI-21328549	0.35
Q2M2I5	Keratin, type I cytoskeletal 24 (Cytokeratin-24) (CK-24) (Keratin-24) (K24) (Type I keratin-24)	EBI-21328549	0.35
P12268	Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II)	EBI-21328549	0.35
P07900	Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)	EBI-21328549	0.35
P35637	RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)	EBI-21328549	0.35
P35527	Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)	EBI-21328549	0.35
P14625	Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)	EBI-21328549	0.35
Q01844	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)	EBI-21328549	0.35
P06493	Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)	EBI-21328549	0.35
Q9UQE7	Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)	EBI-21328549	0.35
Q71RC2	La-related protein 4 (La ribonucleoprotein domain family member 4)	EBI-21328549	0.35
Q92734	Protein TFG (TRK-fused gene protein)	EBI-21328549	0.35
Q6P5R6	60S ribosomal protein L22-like 1 (Large ribosomal subunit protein eL22-like 1)	EBI-21328549	0.35
P11142	Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)	EBI-21328549	0.35
Q9BRP1	Programmed cell death protein 2-like	EBI-21328549	0.35
Q9H3F6	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10)	EBI-21328549	0.35
P35908	Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)	EBI-21328549	0.35
P04264	Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)	EBI-21328549	0.35
P61081	NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)	EBI-21328549	0.53
P13645	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)	EBI-21328549	0.35
Q8N1G4	Leucine-rich repeat-containing protein 47	EBI-21328549	0.35
Q96MP8	BTB/POZ domain-containing protein KCTD7	EBI-21328549	0.35
Q6PI47	BTB/POZ domain-containing protein KCTD18	EBI-21328549	0.35
Q9NXK8	F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12)	EBI-21328549	0.35
Q53G59	Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)	EBI-21328549	0.35
P22830	Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase)	EBI-21328549	0.35
O95219	Sorting nexin-4	EBI-21328549	0.35
Q96T23	Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex)	EBI-21328549	0.35
P49642	DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49)	EBI-21328549	0.35
O60237	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)	EBI-21328549	0.35
Q8NDI1	EH domain-binding protein 1	EBI-21328549	0.35
Q9UGM3	Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	EBI-21328549	0.35
Q6P3S6	F-box only protein 42 (Just one F-box and Kelch domain-containing protein)	EBI-21328549	0.35
Q96NC0	Zinc finger matrin-type protein 2	EBI-21328549	0.35
P13521	Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin]	EBI-21328549	0.35
Q92834	X-linked retinitis pigmentosa GTPase regulator	EBI-21328549	0.35
Q9H4K1	RIB43A-like with coiled-coils protein 2	EBI-21328549	0.35
Q05BQ5	MBT domain-containing protein 1	EBI-21328549	0.35
Q8WXI2	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)	EBI-21328549	0.35
P01042	Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]	EBI-21328549	0.35
Q9NXE8	Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25)	EBI-21328549	0.35
Q6IMN6	Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140)	EBI-21328549	0.35
Q9GZY4	Cytochrome c oxidase assembly factor 1 homolog (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa)	EBI-21328549	0.35
Q9BYV9	Transcription regulator protein BACH2 (BTB and CNC homolog 2)	EBI-21328549	0.35
O75110	Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A)	EBI-21328549	0.35
Q9Y2J4	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)	EBI-21328549	0.35
Q10570	Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)	EBI-21328549	0.35
Q15370	Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2)	EBI-21328549	0.35
P63208	S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)	EBI-21328549	0.35
Q92673	Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)	EBI-21328549	0.35
Q00526	Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)	EBI-21328549	0.35
P78396	Cyclin-A1	EBI-21328549	0.35
Q9NXF7	DDB1- and CUL4-associated factor 16	EBI-21328549	0.35
Q3SXM0	DDB1- and CUL4-associated factor 4-like protein 1 (WD repeat-containing protein 21B)	EBI-21328549	0.35
Q8WVD3	E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)	EBI-21328549	0.35
Q16531	DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)	EBI-21328549	0.35
O94889	Kelch-like protein 18	EBI-21328549	0.35
O94952	F-box only protein 21	EBI-21328549	0.35
Q5T6F0	DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A)	EBI-21328549	0.35
Q92624	Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)	EBI-21328549	0.35
Q8WV16	DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A)	EBI-21328549	0.53
P24941	Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)	EBI-21328549	0.35
P20248	Cyclin-A2 (Cyclin-A) (Cyclin A)	EBI-21328549	0.35
Q7Z7A1	Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110)	EBI-21328549	0.35
Q8N5D0	WD and tetratricopeptide repeats protein 1	EBI-21332205	0.35
Q5TAQ9	DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)	EBI-21332205	0.35
Q5QP82	DDB1- and CUL4-associated factor 10 (WD repeat-containing protein 32)	EBI-21332205	0.35
Q96JK2	DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22)	EBI-21332205	0.35
Q58WW2	DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)	EBI-21332205	0.35
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)	EBI-21332205	0.35
Q53HC5	Kelch-like protein 26	EBI-21332205	0.35
P57775	F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)	EBI-21332205	0.35
Q9Y297	F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)	EBI-21332205	0.56
Q9UKB1	F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)	EBI-21332205	0.35
Q9UK99	F-box only protein 3	EBI-21332205	0.35
Q8NBE8	Kelch-like protein 23	EBI-21332942	0.35
P05412	Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)	EBI-11323169	0.35
P28482	Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)	EBI-11477267	0.54
Q6UXH8	Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog)	EBI-25277037	0.56
Q8N6Y0	Harmonin-binding protein USHBP1 (AIE-75-binding protein) (Mutated in colon cancer protein 2) (MCC-2) (Usher syndrome type-1C protein-binding protein 1) (USH1C-binding protein 1)	EBI-25280965	0.56
Q13515	Phakinin (49 kDa cytoskeletal protein) (Beaded filament structural protein 2) (Lens fiber cell beaded filament protein CP 47) (CP47) (Lens fiber cell beaded filament protein CP 49) (CP49) (Lens intermediate filament-like light) (LIFL-L)	EBI-24539227	0.56
Q15911	Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)	EBI-24561815	0.56
Q92529	SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)	EBI-24585832	0.56
O95704	Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2)	EBI-21591300	0.35
Q9BQ90	Kelch domain-containing protein 3 (Testis intracellular mediator protein)	EBI-21622599	0.35
A1L190	Synaptonemal complex central element protein 3 (Testis highly expressed gene 2 protein) (THEG-2)	EBI-21724977	0.35
Q6JEL2	Kelch-like protein 10	EBI-21755575	0.35
O43583	Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3)	EBI-21785701	0.35
Q7L5Y6	DET1 homolog (De-etiolated-1 homolog)	EBI-21846729	0.35
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	EBI-21360986	0.35
P04156	Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)	EBI-21014477	0.35
Q9NRI5	Disrupted in schizophrenia 1 protein	EBI-21371036	0.00
P06241	Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)	EBI-21371020	0.00
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)	EBI-26513938	0.37
Q15831	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)	EBI-28941407	0.53

Cross-References

Database	Links
UNIPROT	Q7L5N1 A4D2A3 O15387
PDB	4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I
Pfam	PF01398 PF13012
PROSITE	PS50249
OMIM	614729
DisGeNET	10980

COP9 signalosome complex subunit 6 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 4D18)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

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Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (14 interactors)

Interactions with other proteins (293 interactors)

Cross-References

Database

Links

Description

Description