SUMO-conjugating enzyme UBC9 - Homo sapiens

SUMO-conjugating enzyme UBC9 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	SUMO-conjugating enzyme UBC9
Accession Code	P63279
Gene	UBE2I
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 158)
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPP LFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

Structure Viewer (PDB: 2XWU)

Subcellular Location

Description
Nucleus {Experimental EvidencePubMed:16631117, Experimental EvidencePubMed:19744555, Experimental EvidencePubMed:22214662, Experimental EvidencePubMed:27068747}. Cytoplasm {Experimental EvidencePubMed:22214662}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:12573574}. Note=Mainly nuclear (By similarity). In spermatocytes, localizes in synaptonemal complexes (PubMed:8610150). Recruited by BCL11A into the nuclear body (By similarity). {By SimilarityUniProtKB:P63280, ECO:0000269\|PubMed:8610150}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nuclear Envelope (GO:0005635) Nuclear Pore (GO:0005643) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) PML Body (GO:0016605) SUMO Ligase Complex (GO:0106068) Obsolete Sumoylated E2 Ligase Complex (GO:1990356) Synaptonemal Complex (GO:0000795) Transferase Complex (GO:1990234)

Biology & Function

Description
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705). {Experimental EvidencePubMed:11451954, Experimental EvidencePubMed:15809060, Experimental EvidencePubMed:17466333, Experimental EvidencePubMed:19638400, Experimental EvidencePubMed:19744555, Experimental EvidencePubMed:20077568, Experimental EvidencePubMed:26524494, Experimental EvidencePubMed:26620705, Experimental EvidencePubMed:27211601, Experimental EvidencePubMed:8668529}.
Assigned Ontology terms

Biological Process	Cell Division (GO:0051301) Chromosome Segregation (GO:0007059) Mitotic Nuclear Membrane Reassembly (GO:0007084) Negative Regulation Of DNA-Templated Transcription (GO:0045892) Negative Regulation Of Transcription By RNA Polymerase II (GO:0000122) Nuclear Export (GO:0051168) Positive Regulation Of I-KappaB Kinase/NF-KappaB Signaling (GO:0043123) Positive Regulation Of SUMO Transferase Activity (GO:1903755) Protein Modification Process (GO:0036211) Protein Sumoylation (GO:0016925) Ubiquitin-Dependent Protein Catabolic Process (GO:0006511)
Molecular Function	ATP Binding (GO:0005524) Enzyme Binding (GO:0019899) HLH Domain Binding (GO:0043398) RING-Like Zinc Finger Domain Binding (GO:0071535) RNA Binding (GO:0003723) Small Protein Activating Enzyme Binding (GO:0044388) SUMO Conjugating Enzyme Activity (GO:0061656) SUMO Transferase Activity (GO:0019789) Transcription Coregulator Binding (GO:0001221) Transcription Factor Binding (GO:0008134)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (31 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P63279	Self	EBI-3934322	0.59
Q9NRG9	Aladin	EBI-11105225	0.35
Q9H444	Charged multivesicular body protein 4b	EBI-757456	0.55
Q92905	COP9 signalosome complex subunit 5	EBI-3454145	0.00
Q06787	Fragile X messenger ribonucleoprotein 1	EBI-11105225	0.35
Q14974	Importin subunit beta-1	EBI-11105225	0.35
P59595	Nucleoprotein	EBI-25497306	0.75
Q9BTX1	Nucleoporin NDC1	EBI-11105225	0.35
P0CK47	Nuclear egress protein 1	EBI-2622494	0.37
O14524	Nuclear envelope integral membrane protein 1	EBI-21695903	0.35
P57740	Nuclear pore complex protein Nup107	EBI-11105225	0.35
Q8BH74	Nuclear pore complex protein Nup107	EBI-10997196	0.35
P49790	Nuclear pore complex protein Nup153	EBI-11076796	0.35
Q92621	Nuclear pore complex protein Nup205	EBI-11105225	0.35
P35658	Nuclear pore complex protein Nup214	EBI-11105225	0.35
Q8NFH5	Nucleoporin NUP35	EBI-11105225	0.35
Q9BW27	Nuclear pore complex protein Nup85	EBI-11105225	0.35
Q8N1F7	Nuclear pore complex protein Nup93	EBI-11105225	0.35
P52948	Nuclear pore complex protein Nup96	EBI-11105225	0.35
Q6PFD9	Nuclear pore complex protein Nup96	EBI-10994876	0.35
Q9UBU9	Nuclear RNA export factor 1	EBI-11105225	0.35
Q8TEM1	Nuclear pore membrane glycoprotein 210	EBI-11105225	0.35
P29991	RNA-directed RNA polymerase NS5	EBI-8828210	0.37
P46060	Ran GTPase-activating protein 1	EBI-7036111	0.95
P46061	Ran GTPase-activating protein 1	EBI-1033068	0.44
P62826	GTP-binding nuclear protein Ran	EBI-11105225	0.53
P49792	E3 SUMO-protein ligase RanBP2	EBI-11105225	0.75
Q9ERU9	E3 SUMO-protein ligase RanBP2	EBI-2555617	0.56
Q8TEB7	E3 ubiquitin-protein ligase RNF128	EBI-2341627	0.37
Q96EE3	Nucleoporin SEH1	EBI-11105225	0.35
P63165	Small ubiquitin-related modifier 1	EBI-7406754	0.95
Interactions with other proteins (227 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9UBC3	DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)	EBI-80228	0.57
P04637	Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)	EBI-7311368	0.74
Q9H2X6	Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)	EBI-7631615	0.72
P12757	Ski-like protein (Ski-related oncogene) (Ski-related protein)	EBI-7228470	0.37
O75400	Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)	EBI-7243310	0.37
Q13485	Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)	EBI-7248833	0.83
Q8TAD8	Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1)	EBI-7264331	0.37
Q13432	Protein unc-119 homolog A (Retinal protein 4) (hRG4)	EBI-731083	0.00
Q8NDC0	MAPK-interacting and spindle-stabilizing protein-like (Mitogen-activated protein kinase 1-interacting protein 1-like)	EBI-752968	0.37
Q96B23	Uncharacterized protein C18orf25 (ARKadia-like protein 1)	EBI-753160	0.37
Q01826	DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)	EBI-753613	0.55
Q9UI36	Dachshund homolog 1 (Dach1)	EBI-753847	0.37
Q8IVD9	NudC domain-containing protein 3	EBI-753934	0.37
Q13422	DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)	EBI-754453	0.37
O43353	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)	EBI-754693	0.37
Q9NR12	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)	EBI-755017	0.37
O15015	Zinc finger protein 646	EBI-755329	0.37
Q9UKT9	Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)	EBI-755677	0.55
P78364	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)	EBI-757324	0.37
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)	EBI-757864	0.37
Q9Y620	DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B)	EBI-757909	0.37
O96006	E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)	EBI-757915	0.37
Q14134	Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein)	EBI-758929	0.37
P07910	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)	EBI-759535	0.37
Q9Y4E5	E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)	EBI-759886	0.75
P61978	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)	EBI-759901	0.37
O75928	E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)	EBI-760369	0.85
P03116	Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)	EBI-7316634	0.53
P03114	Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)	EBI-8608879	0.37
P56693	Transcription factor SOX-10	EBI-8087364	0.51
Q92754	Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1)	EBI-937323	0.65
P05549	Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)	EBI-937334	0.65
Q92481	Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta)	EBI-937338	0.37
P54253	Ataxin-1 (Spinocerebellar ataxia type 1 protein)	EBI-25975778	0.67
Q14103	Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)	EBI-1024489	0.44
Q9UBE0	SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]	EBI-11105225	0.67
Q9UBT2	SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)	EBI-11105225	0.81
O60739	Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20)	EBI-1067098	0.00
P56537	Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP))	EBI-1068752	0.00
P55854	Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)	EBI-21854443	0.56
Q14164	Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)	EBI-1076631	0.00
P19419	ETS domain-containing protein Elk-1	EBI-7035929	0.73
O00482	Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)	EBI-7035992	0.44
Q99497	Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124)	EBI-1164415	0.37
O14503	Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)	EBI-1164831	0.58
P09936	Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)	EBI-1181901	0.37
P61956	Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)	EBI-7406892	0.59
Q9Y3V2	RWD domain-containing protein 3 (RWD domain-containing sumoylation enhancer) (RSUME)	EBI-1549893	0.61
P22314	Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)	EBI-1550743	0.40
Q9UER7	Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)	EBI-1559558	0.65
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)	EBI-2117151	0.00
Q9H307	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)	EBI-2339638	0.37
Q06265	Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)	EBI-2339635	0.55
Q15047	Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)	EBI-2339647	0.55
Q9UKL3	CASP8-associated protein 2 (FLICE-associated huge protein)	EBI-2339662	0.55
Q5T6S3	PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)	EBI-2339683	0.37
Q9Y692	Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96)	EBI-2339671	0.37
Q9NPI1	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)	EBI-2339689	0.37
Q96RL1	BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)	EBI-2339692	0.37
Q9NVP2	Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)	EBI-2339695	0.37
Q8N5U6	RING finger protein 10	EBI-2340651	0.37
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)	EBI-2340654	0.74
P36406	E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)	EBI-2341573	0.37
P35226	Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)	EBI-2341582	0.37
O60683	Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69)	EBI-2341585	0.37
Q13064	Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)	EBI-2341594	0.37
P14373	Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (RING-type E3 ubiquitin transferase TRIM27) (Ret finger protein) (Tripartite motif-containing protein 27)	EBI-2341588	0.37
P78317	E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF)	EBI-2341591	0.55
Q86Y13	E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138)	EBI-2341597	0.37
O60291	E3 ubiquitin-protein ligase MGRN1 (EC 2.3.2.27) (Mahogunin RING finger protein 1) (RING finger protein 156) (RING-type E3 ubiquitin transferase MGRN1)	EBI-2341600	0.37
Q9ULV8	E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)	EBI-2341603	0.37
Q9HBD1	Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)	EBI-2341606	0.37
Q9NX47	E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5)	EBI-2341609	0.37
Q9NS91	E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18)	EBI-2341616	0.37
Q8WV44	E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41)	EBI-2341630	0.37
Q8WVZ7	E3 ubiquitin-protein ligase RNF133 (EC 2.3.2.27) (RING finger protein 133) (RING-type E3 ubiquitin transferase RNF133)	EBI-2341639	0.37
Q96GF1	E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185)	EBI-2341633	0.37
Q8TDB6	E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)	EBI-2341636	0.37
Q6ZMU5	Tripartite motif-containing protein 72 (Mitsugumin-53) (Mg53)	EBI-2341654	0.37
Q8N448	Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1)	EBI-2341642	0.37
Q7Z419	E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.31) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein)	EBI-2341645	0.37
Q969V5	Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 2.3.2.27) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (Protein Hades) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) (RING-type E3 ubiquitin transferase NFKB 1)	EBI-6987892	0.46
Q99856	AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (Dead ringer-like protein 1) (E2F-binding protein 1)	EBI-8566246	0.35
P03431	RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)	EBI-2547959	0.37
P03496	Non-structural protein 1 (NS1) (NS1A)	EBI-2547964	0.37
P03495	Non-structural protein 1 (NS1) (NS1A)	EBI-2549251	0.37
A0A2S9PGA1	Putative membrane protein	EBI-2840146	0.00
P16220	Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)	EBI-3439128	0.00
P15104	Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225)	EBI-3439744	0.00
Q12772	Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]	EBI-3451605	0.00
Q7Z333	Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin)	EBI-10093986	0.55
B3KQF8	cDNA FLJ90387 fis, clone NT2RP2005391, highly similar to Homo sapiens activating transcription factor 7 interacting protein (ATF7IP), mRNA	EBI-3452423	0.00
Q14789	Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin)	EBI-3452458	0.00
Q86Z02	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2)	EBI-3452479	0.00
Q9H422	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Androgen receptor-interacting nuclear protein kinase) (ANPK) (Fas-interacting serine/threonine-protein kinase) (FIST) (Homolog of protein kinase YAK1)	EBI-3452493	0.00
O75925	E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)	EBI-3452528	0.00
Q9Y6X2	E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)	EBI-3935553	0.55
P23497	Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)	EBI-3452577	0.00
Q9H2Y7	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474)	EBI-3452619	0.00
Q9UBW7	Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198)	EBI-3452633	0.00
B2RMV2	Cytospin-A	EBI-3452654	0.00
O95817	BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)	EBI-3454131	0.00
P03928	ATP synthase protein 8 (A6L) (F-ATPase subunit 8)	EBI-3454124	0.00
Q00610	Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)	EBI-3454138	0.00
Q14315	Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)	EBI-3454152	0.00
P10644	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)	EBI-3454159	0.00
P31321	cAMP-dependent protein kinase type I-beta regulatory subunit	EBI-3454166	0.00
Q96S59	Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7)	EBI-3454173	0.00
P19634	Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)	EBI-3454180	0.00
Q15714	TSC22 domain family protein 1 (Cerebral protein 2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)	EBI-3454194	0.00
Q8NDV7	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)	EBI-3454187	0.00
O75534	Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR)	EBI-3454201	0.00
Q9Y3S1	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)	EBI-3454208	0.00
Q15942	Zyxin (Zyxin-2)	EBI-3454215	0.00
O94829	Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)	EBI-8534332	0.72
Q15645	Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13)	EBI-8649412	0.37
Q6RW13	Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein)	EBI-8650154	0.37
O15381	Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein)	EBI-8658018	0.37
Q13287	N-myc-interactor (Nmi) (N-myc and STAT interactor)	EBI-8658035	0.37
Q03060	cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER)	EBI-3928044	0.37
P56545	C-terminal-binding protein 2 (CtBP2)	EBI-3928496	0.44
P29590	Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)	EBI-3933045	0.44
O43255	E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)	EBI-3933909	0.37
Q9NQB0	Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)	EBI-3934076	0.44
O14544	Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)	EBI-3934342	0.37
Q9UKY1	Zinc fingers and homeoboxes protein 1	EBI-3936749	0.37
Q8N2W9	E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)	EBI-3940111	0.37
Q99684	Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163)	EBI-4292025	0.37
Q86UP2	Kinectin (CG-1 antigen) (Kinesin receptor)	EBI-5660349	0.00
Q8WZ42	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)	EBI-5666456	0.00
P56524	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-6112566	0.51
Q9UQL6	Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)	EBI-6112579	0.37
Q9BZ95	Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)	EBI-8487253	0.37
Q86X55	Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4)	EBI-8487291	0.37
P15884	Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)	EBI-9212397	0.35
Q92793	CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)	EBI-9212397	0.35
P45481	Histone lysine acetyltransferase CREBBP (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)	EBI-9212425	0.44
P03230	Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25]	EBI-9349997	0.52
Q07869	Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)	EBI-9511901	0.44
O41955	Cytoplasmic envelopment protein 3	EBI-9640696	0.37
O41969	Packaging protein UL32	EBI-9641541	0.37
P0C206	Protein Rex (Rev homolog) (Rex-1) (p27Rex)	EBI-9675668	0.49
P60896	26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)	EBI-9827158	0.35
G2XKQ0	Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6)	EBI-10220912	0.56
Q08379	Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)	EBI-10220932	0.66
Q8N3Z6	Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7)	EBI-10220952	0.56
Q8WWZ3	Ectodysplasin-A receptor-associated adapter protein (EDAR-associated death domain protein) (Protein crinkled homolog)	EBI-10220962	0.56
Q9HCK0	Zinc finger and BTB domain-containing protein 26 (Zinc finger protein 481) (Zinc finger protein Bioref)	EBI-10220972	0.56
P41212	Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel)	EBI-10491265	0.37
Q5U0E4	Cellular tumor antigen p53	EBI-10491279	0.37
Q04360	mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)	EBI-11736551	0.37
Q8VE37	Regulator of chromosome condensation (Chromosome condensation protein 1)	EBI-11043815	0.35
P18754	Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)	EBI-11105225	0.35
Q9ULR0	Pre-mRNA-splicing factor ISY1 homolog	EBI-11105225	0.35
Q8IZ21	Phosphatase and actin regulator 4	EBI-11105225	0.35
Q96SK2	Transmembrane protein 209	EBI-11105225	0.35
E9PF10	Nuclear pore complex protein Nup155	EBI-11105225	0.35
O60333	Kinesin-like protein KIF1B (Klp)	EBI-11105225	0.35
F5GZ90	Denticleless protein homolog	EBI-11105225	0.35
Q8CH72	E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32)	EBI-11114497	0.35
P04046	Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase)	EBI-11522871	0.56
P15873	Proliferating cell nuclear antigen (PCNA)	EBI-11523508	0.56
P17423	Homoserine kinase (HK) (HSK) (EC 2.7.1.39)	EBI-11523598	0.56
P25354	DUP240 protein YCR007C	EBI-11524281	0.56
P25515	V-type proton ATPase subunit c (V-ATPase subunit c) (Guanine nucleotide exchange factor 2) (V-ATPase 16 kDa proteolipid subunit 1) (Vacuolar proton pump c subunit)	EBI-11524613	0.56
P25453	Meiotic recombination protein DMC1	EBI-11524604	0.56
P25611	Regulator of drug sensitivity 1	EBI-11524667	0.56
P27515	Uridine kinase (EC 2.7.1.48) (Uridine monophosphokinase)	EBI-11524895	0.56
P32458	Cell division control protein 11	EBI-11525398	0.56
P32502	Translation initiation factor eIF-2B subunit beta (GCD complex subunit GCD7) (Guanine nucleotide exchange factor subunit GCD7) (eIF-2B GDP-GTP exchange factor subunit beta)	EBI-11525940	0.56
P32562	Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC 2.7.11.21)	EBI-11526605	0.56
P33417	Intrastrand cross-link recognition protein (Structure-specific recognition protein) (SSRP)	EBI-11527138	0.56
P35192	Metal-binding activator 1	EBI-11527429	0.56
P37263	UPF0743 protein YCR087C-A	EBI-11527656	0.56
P38319	Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)	EBI-11528157	0.56
P38340	Alpha N-terminal protein methyltransferase 1 (EC 2.1.1.244) (Translation associated element 1) (X-Pro-Lys N-terminal protein methyltransferase 1) (NTM1)	EBI-11528622	0.56
P38703	Ceramide synthase LAG1 (Longevity assurance factor 1) (Longevity assurance gene 1 protein) (Longevity assurance protein 1) (Very-long-chain ceramide synthase LAG1) (EC 2.3.1.297)	EBI-11529305	0.56
P38838	DNA-dependent metalloprotease WSS1 (EC 3.4.24.-) (DNA damage response protein WSS1) (SUMO-dependent isopeptidase WSS1) (Weak suppressor of SMT3 protein 1)	EBI-11529593	0.56
P38986	L-asparaginase 1 (EC 3.5.1.1) (L-asparaginase I) (L-asparagine amidohydrolase I) (ASP I)	EBI-11529746	0.56
P38991	Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora kinase) (Increase-in-ploidy protein 1)	EBI-11529764	0.56
P40151	DNA-dependent ATPase MGS1 (Maintenance of genome stability protein 1)	EBI-11530459	0.56
P40473	Transcriptional activator POG1 (Promoter of growth protein 1)	EBI-11531218	0.56
P40956	Protein GTS1 (Protein LSR1)	EBI-11531611	0.56
P46985	Probable alpha-1,6-mannosyltransferase MNN11 (EC 2.4.1.-) (Mannan polymerase II complex MNN11 subunit) (M-Pol II subunit MNN11)	EBI-11532107	0.56
P49723	Ribonucleoside-diphosphate reductase small chain 2 (EC 1.17.4.1) (Ribonucleotide reductase R2 subunit 2) (Ribonucleotide reductase small subunit 2)	EBI-11532821	0.56
P53176	Multicopy suppressor of SEC21 protein 27 (DUP240 protein MST27) (Protein DUP2)	EBI-11533108	0.56
P53174	Pheromone-regulated membrane protein 8 (DUP240 protein PRM8) (Protein DUP1)	EBI-11533099	0.56
P53243	Zinc finger protein YGR067C	EBI-11533171	0.56
P53252	Sphingolipid long chain base-responsive protein PIL1	EBI-11533206	0.56
P53286	Protein BTN2 (Batten disease protein 2)	EBI-11533278	0.56
P60010	Actin (EC 3.6.4.-)	EBI-11534056	0.56
Q03063	Down-regulator of invasive growth 1 (Regulator of STE12 protein 1) (Regulator of sterile twelve 1)	EBI-11534775	0.56
Q03373	Down-regulator of invasive growth 2 (Regulator of STE12 protein 2) (Regulator of sterile twelve 2)	EBI-11534875	0.56
Q03718	Non-structural maintenance of chromosome element 5 (Non-SMC element 5)	EBI-11534950	0.56
Q04110	Protein ECM11 (Extracellular mutant protein 11)	EBI-11535060	0.56
Q06178	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (NAD(+) diphosphorylase 1) (NAD(+) pyrophosphorylase 1) (Nicotinamide-nucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (NMNAT 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) (NaMNAT 1)	EBI-11535560	0.56
Q06340	Protein ESC2 (Establishes silent chromatin protein 2)	EBI-11535605	0.56
Q08581	Kinetochore protein SLK19 (Synthetic lethal KAR3 protein 19)	EBI-11536317	0.56
Q12020	Protein SRL2 (Suppressor of RAD53 null lethality protein 2)	EBI-11536399	0.56
Q12206	Transcriptional modulator WTM2	EBI-11536864	0.56
Q12306	Ubiquitin-like protein SMT3	EBI-11537161	0.56
Q12439	Transposon Ty2-OR1 Gag polyprotein (TY2A) (TYA) (Transposon Ty2 protein A) [Cleaved into: Capsid protein (CA); Gag-p4]	EBI-11537405	0.56
Q9HD42	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1)	EBI-11511224	0.37
Q9NZZ3	Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)	EBI-11512517	0.37
Q12800	Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF)	EBI-11770132	0.49
Q96IK5	Germ cell-less protein-like 1 (Spermatogenesis-associated protein 29)	EBI-11771440	0.49
Q9QXY6	EH domain-containing protein 3	EBI-11685546	0.44
P61769	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	EBI-21675069	0.35
P22460	Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)	EBI-15620337	0.40
Q9Y265	RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)	EBI-15676218	0.50
Q02078	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)	EBI-15799705	0.44
O00180	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1)	EBI-15856059	0.27
P03243	E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)	EBI-16149899	0.40
P04040	Catalase (EC 1.11.1.6)	EBI-16789632	0.27
P11474	Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)	EBI-20303027	0.44
P62508	Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)	EBI-20303735	0.44
Q12888	TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)	EBI-20207896	0.27
P02649	Apolipoprotein E (Apo-E)	EBI-21388153	0.00
O00499	Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1)	EBI-21388141	0.00
P09429	High mobility group protein B1 (High mobility group protein 1) (HMG-1)	EBI-21461795	0.37
Q9BYV2	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)	EBI-22024844	0.00
P42858	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-25959819	0.56
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)	EBI-28952196	0.27
P10070	Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein)	EBI-29016408	0.27
P35712	Transcription factor SOX-6	EBI-29730925	0.27
P48436	Transcription factor SOX-9	EBI-29732788	0.27
P40763	Signal transducer and activator of transcription 3 (Acute-phase response factor)	EBI-29762103	0.27

Cross-References

Database	Links
UNIPROT	P63279 D3DU69 P50550 Q15698 Q59GX1 Q86VB3
PDB	1A3S 1KPS 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP 4W5V 4Y1L 5D2M 5F6D 5F6E 5F6U 5F6V 5F6W 5F6X 5F6Y 5FQ2 6SYF
Pfam	PF00179
PROSITE	PS00183 PS50127
OMIM	601661
DisGeNET	7329

SUMO-conjugating enzyme UBC9 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 2XWU)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (31 interactors)

Interactions with other proteins (227 interactors)

Cross-References

Database

Links

Description

Description