Importin subunit beta-1 - Homo sapiens

Importin subunit beta-1 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Importin subunit beta-1
Accession Code	Q14974
Gene	KPNB1
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 876)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW LAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQD IDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQ YLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQ VLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLG GEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSF IDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA

Structure Viewer (PDB: 1F59)

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:11891849}. Nucleus envelope {Experimental EvidencePubMed:11891849}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytoplasmic Stress Granule (GO:0010494) Cytosol (GO:0005829) Endoplasmic Reticulum Tubular Network (GO:0071782) Extracellular Exosome (GO:0070062) Extracellular Region (GO:0005576) Ficolin-1-Rich Granule Lumen (GO:1904813) Membrane (GO:0016020) NLS-Dependent Protein Nuclear Import Complex (GO:0042564) Nuclear Envelope (GO:0005635) Nuclear Membrane (GO:0031965) Nuclear Pore (GO:0005643) Nucleoplasm (GO:0005654) Nucleus (GO:0005634) Specific Granule Lumen (GO:0035580)

Biology & Function

Description
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In association with IPO7, mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. {Experimental EvidencePubMed:10228156, Experimental EvidencePubMed:11682607, Experimental EvidencePubMed:11891849, Experimental EvidencePubMed:19386897, Experimental EvidencePubMed:24699649, Experimental EvidencePubMed:9687515}.
Assigned Ontology terms

Biological Process	Astral Microtubule Organization (GO:0030953) Establishment Of Mitotic Spindle Localization (GO:0040001) Establishment Of Protein Localization (GO:0045184) Mitotic Chromosome Movement Towards Spindle Pole (GO:0007079) Mitotic Metaphase Plate Congression (GO:0007080) Mitotic Spindle Assembly (GO:0090307) NLS-Bearing Protein Import Into Nucleus (GO:0006607) Protein Import Into Nucleus (GO:0006606) Ran Protein Signal Transduction (GO:0031291) Ribosomal Protein Import Into Nucleus (GO:0006610) RNA Import Into Nucleus (GO:0006404)
Molecular Function	Enzyme Binding (GO:0019899) Hsp90 Protein Binding (GO:0051879) Importin-Alpha Family Protein Binding (GO:0061676) Nuclear Import Signal Receptor Activity (GO:0061608) Nuclear Localization Sequence Binding (GO:0008139) Protein Domain Specific Binding (GO:0019904) RNA Binding (GO:0003723) Small GTPase Binding (GO:0031267) Zinc Ion Binding (GO:0008270)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (51 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
A0A142I5B9	RNA-directed RNA polymerase NS5	EBI-20625330	0.35
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	EBI-30827108	0.44
A8CG34	Nuclear envelope pore membrane protein POM 121C	EBI-11115566	0.59
O14524	Nuclear envelope integral membrane protein 1	EBI-11115566	0.35
O15504	Nucleoporin NUP42	EBI-11115566	0.35
O95295	SNARE-associated protein Snapin	EBI-5664409	0.00
P02545	Lamin-A/C	EBI-16795756	0.27
P14907	Nucleoporin NSP1	EBI-1034546	0.62
P35658	Nuclear pore complex protein Nup214	EBI-30827243	0.44
P46060	Ran GTPase-activating protein 1	EBI-11115566	0.35
P49790	Nuclear pore complex protein Nup153	EBI-11076796	0.77
P49792	E3 SUMO-protein ligase RanBP2	EBI-11115566	0.35
P52948	Nuclear pore complex protein Nup96	EBI-11115566	0.35
P57740	Nuclear pore complex protein Nup107	EBI-11115566	0.35
P62826	GTP-binding nuclear protein Ran	EBI-11115566	0.53
P63165	Small ubiquitin-related modifier 1	EBI-11115566	0.35
P63279	SUMO-conjugating enzyme UBC9	EBI-11105225	0.35
P70168	Importin subunit beta-1	EBI-2555147	0.40
P78406	mRNA export factor RAE1	EBI-11115566	0.35
Q12769	Nuclear pore complex protein Nup160	EBI-11115566	0.35
Q9ERU9	E3 SUMO-protein ligase RanBP2	EBI-2555617	0.56
Q14974	Self	EBI-7166773	0.44
Q9UH99	SUN domain-containing protein 2	EBI-8021405	0.40
Q6PFD9	Nuclear pore complex protein Nup96	EBI-10994876	0.35
Q8BH74	Nuclear pore complex protein Nup107	EBI-10997196	0.35
Q5SRE5	Nucleoporin NUP188	EBI-11115566	0.35
Q8WUM0	Nuclear pore complex protein Nup133	EBI-11115566	0.35
Q96EE3	Nucleoporin SEH1	EBI-11115566	0.35
Q92621	Nuclear pore complex protein Nup205	EBI-11115566	0.35
Q8NFH5	Nucleoporin NUP35	EBI-11115566	0.35
Q9UKX7	Nuclear pore complex protein Nup50	EBI-11115566	0.35
Q8N1F7	Nuclear pore complex protein Nup93	EBI-11115566	0.35
Q9NXE4	Sphingomyelin phosphodiesterase 4	EBI-11115566	0.35
Q8NFH4	Nucleoporin Nup37	EBI-11115566	0.35
Q8NFH3	Nucleoporin Nup43	EBI-11115566	0.35
Q8TEM1	Nuclear pore membrane glycoprotein 210	EBI-11115566	0.35
Q9BTX1	Nucleoporin NDC1	EBI-11115566	0.35
Q99567	Nuclear pore complex protein Nup88	EBI-11115566	0.35
Q9UBU9	Nuclear RNA export factor 1	EBI-11115566	0.35
Q9BW27	Nuclear pore complex protein Nup85	EBI-11115566	0.35
Q9WMX2	RNA-directed RNA polymerase	EBI-11513409	0.50
Q96HA1	Nuclear envelope pore membrane protein POM 121	EBI-30827588	0.44
Q9NRG9	Aladin	EBI-11115566	0.35
Q9R1K9	Centrin-2	EBI-11111151	0.35
Q15642	Cdc42-interacting protein 4	EBI-30827298	0.44
Q92905	COP9 signalosome complex subunit 5	EBI-21325777	0.35
Q9UPY3	Endoribonuclease Dicer	EBI-20621330	0.35
P00533	Epidermal growth factor receptor	EBI-702075	0.35
P04626	Receptor tyrosine-protein kinase erbB-2	EBI-4373084	0.57
Q53GS7	mRNA export factor GLE1	EBI-11115566	0.35
Q02821	Importin subunit alpha	EBI-13942487	0.44
Interactions with other proteins (213 interactors)

Partner (UniProt)		IntAct	Confidence score
P52292	Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)	EBI-286795	0.93
Q9GK30	Parathyroid hormone-related protein (PTH-rP) (PTHrP)	EBI-8580826	0.44
Q9NRA8	Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)	EBI-301394	0.35
Q01201	Transcription factor RelB (I-Rel)	EBI-363445	0.00
P20333	Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]	EBI-364543	0.00
Q15628	Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)	EBI-364816	0.00
Q9Y4K3	TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)	EBI-365110	0.00
P60709	Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]	EBI-353790	0.40
Q16637	Survival motor neuron protein (Component of gems 1) (Gemin-1)	EBI-464895	0.52
O75940	Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1)	EBI-464916	0.40
Q12873	Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)	EBI-474956	0.37
Q8N2W9	E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)	EBI-475005	0.37
P21246	Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor) (HBNF) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1)	EBI-475012	0.37
Q15796	Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)	EBI-7224889	0.37
P51178	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)	EBI-7795361	0.60
O92837	Minor capsid protein	EBI-8512780	0.40
P03087	Major capsid protein VP1 (Major structural protein VP1)	EBI-8512862	0.44
P03126	Protein E6	EBI-8592423	0.44
P03107	Minor capsid protein L2	EBI-7362635	0.44
P03101	Major capsid protein L1	EBI-7362692	0.62
P63104	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)	EBI-7194971	0.40
P13569	Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)	EBI-1171566	0.64
P01106	Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)	EBI-1237540	0.35
P32121	Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)	EBI-1642843	0.35
Q00005	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta)	EBI-2211497	0.35
Q9Z0E3	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog)	EBI-2549710	0.35
Q9QWT9	Kinesin-like protein KIFC1	EBI-2558911	0.40
E9PVX6	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67 homolog) (Antigen KI-67 homolog) (Antigen Ki67 homolog)	EBI-2561030	0.40
Q9D4G9	RecQ-mediated genome instability protein 1	EBI-2561931	0.40
Q9D0T1	NHP2-like protein 1 (Fertilization antigen 1) (FA-1) (High mobility group-like nuclear protein 2 homolog 1) (Sperm-specific antigen 1) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]	EBI-2563541	0.40
Q8N0X7	Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)	EBI-2643801	0.35
Q5NEH1	Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (Carbamoyl-phosphate synthetase ammonia chain)	EBI-2805872	0.00
Q13573	SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein)	EBI-7950968	0.35
Q99459	Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein)	EBI-7954144	0.35
Q5EWX9	Nuclear pore protein pom121 (nuclear envelope pore membrane protein POM 121)	EBI-8070469	0.35
Q16658	Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)	EBI-2893273	0.35
O00629	Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)	EBI-8291902	0.74
Q8K4J6	Myocardin-related transcription factor A (MRTF-A) (Basic SAP coiled-coil transcription activator) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein homolog) (Megakaryocytic acute leukemia protein homolog)	EBI-8292094	0.52
Q00610	Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)	EBI-4373239	0.35
Q15075	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2)	EBI-4373273	0.35
P42566	Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)	EBI-4373380	0.40
P50570	Dynamin-2 (EC 3.6.5.5)	EBI-4373384	0.35
Q14696	LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61)	EBI-7246101	0.37
Q5TAQ9	DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)	EBI-7817974	0.40
P0C1C7	Protein W	EBI-6157992	0.35
P0C1C6	Protein W	EBI-6158469	0.35
Q05322	Membrane-associated protein VP24 (Ebola VP24) (eVP24)	EBI-6159823	0.35
P19320	Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106)	EBI-6191068	0.53
Q77M19	V protein	EBI-6270503	0.35
P02751	Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]	EBI-6285956	0.35
P49761	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)	EBI-6380381	0.35
Q9UBE8	Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1)	EBI-6381385	0.35
Q9UQ88	Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)	EBI-6381526	0.35
Q86VP6	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)	EBI-21322532	0.35
Q13618	Cullin-3 (CUL-3)	EBI-21329068	0.35
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	EBI-9515510	0.53
Q13043	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]	EBI-10049645	0.35
Q13418	Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)	EBI-10103376	0.35
O60674	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)	EBI-10103554	0.35
Q96FW1	Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)	EBI-10770198	0.35
P05412	Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)	EBI-11323169	0.35
P04620	Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression of viral proteins)	EBI-10687139	0.58
P03225	Protein BDLF2	EBI-11722220	0.35
P0C739	Protein BNLF2a	EBI-11725101	0.35
E9PUA5	Kinesin-like protein	EBI-11016929	0.35
Q8VE37	Regulator of chromosome condensation (Chromosome condensation protein 1)	EBI-11043815	0.35
P63280	SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (mUBC9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)	EBI-11044140	0.35
P34022	Ran-specific GTPase-activating protein (HpaII tiny fragments locus 9a protein) (Ran-binding protein 1) (RANBP1)	EBI-11080066	0.35
Q15398	Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP)	EBI-11083028	0.53
Q6PFD6	Kinesin-like protein KIF18B	EBI-11093571	0.35
P18754	Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)	EBI-11115566	0.35
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)	EBI-11115566	0.35
Q96JN0	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)	EBI-11115566	0.35
Q69YN4	Protein virilizer homolog	EBI-11115566	0.35
P52294	Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]	EBI-11115566	0.69
Q96JA3	Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86)	EBI-11115566	0.35
Q15544	Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28)	EBI-11115566	0.35
P62495	Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)	EBI-11115566	0.35
O60684	Importin subunit alpha-7 (Karyopherin subunit alpha-6)	EBI-11115566	0.59
Q96G23	Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)	EBI-11115566	0.35
I3L0N3	Vesicle-fusing ATPase (EC 3.6.4.6)	EBI-11115566	0.35
Q8TEP8	Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2)	EBI-11115566	0.35
O14715	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)	EBI-11115566	0.35
O15541	E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183)	EBI-11115566	0.35
Q96P63	Serpin B12	EBI-11115566	0.35
Q8NI27	THO complex subunit 2 (Tho2) (hTREX120)	EBI-11115566	0.35
Q92750	Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105)	EBI-11115566	0.35
P51648	Aldehyde dehydrogenase family 3 member A2 (EC 1.2.1.3) (EC 1.2.1.94) (Aldehyde dehydrogenase 10) (Fatty aldehyde dehydrogenase) (Microsomal aldehyde dehydrogenase)	EBI-11115566	0.35
J3QR07	YTH domain-containing protein 1	EBI-11115566	0.35
Q6NUQ4	Transmembrane protein 214	EBI-11115566	0.35
Q9BXS6	Nucleolar and spindle-associated protein 1 (NuSAP)	EBI-11115566	0.35
Q69YH5	Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man)	EBI-11115566	0.35
Q9UDW1	Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein)	EBI-11115566	0.35
Q86VU5	Catechol O-methyltransferase domain-containing protein 1 (EC 2.1.1.-)	EBI-11115566	0.35
Q9BW19	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET)	EBI-11115566	0.35
E9PF10	Nuclear pore complex protein Nup155	EBI-11115566	0.35
O75448	Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)	EBI-11115566	0.35
Q96SK2	Transmembrane protein 209	EBI-11115566	0.35
Q9P0U3	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)	EBI-11115566	0.35
P43487	Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)	EBI-11115566	0.35
Q53EZ4	Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6)	EBI-11115566	0.35
Q8N2Y8	AP-4 complex accessory subunit RUSC2 (Interacting protein of Rab1) (Iporin) (RUN and SH3 domain-containing protein 2)	EBI-11115566	0.35
P55084	Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]	EBI-11115566	0.35
O95373	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)	EBI-11115566	0.59
O00505	Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma)	EBI-11115566	0.71
Q6PJT7	Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37)	EBI-11115566	0.35
O14975	Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase)	EBI-11115566	0.35
Q9HB58	Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110)	EBI-11115566	0.35
O75909	Cyclin-K	EBI-11115566	0.35
Q86VQ0	Lebercilin (Leber congenital amaurosis 5 protein)	EBI-11363336	0.35
P48039	Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)	EBI-11577056	0.00
O96017	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)	EBI-11579031	0.35
P27105	Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)	EBI-12452286	0.51
Q71U36	Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	EBI-11897791	0.35
P03427	Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)	EBI-14404759	0.35
P46531	Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]	EBI-13915571	0.35
A9QM74	Importin subunit alpha-8 (Karyopherin subunit alpha-7)	EBI-13950021	0.44
O15355	Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma)	EBI-14023765	0.35
O15297	Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)	EBI-14024588	0.53
P36873	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)	EBI-14025388	0.42
P56180	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Cancer/testis antigen 44) (CT44) (Transmembrane phosphatase with tensin homology) (Tumor antigen BJ-HCC-5)	EBI-14025693	0.42
P62140	Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)	EBI-14026087	0.42
Q6IQ23	Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)	EBI-16398399	0.59
P10275	Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)	EBI-15187911	0.40
O43524	Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)	EBI-15187932	0.35
Q9NPC8	Homeobox protein SIX2 (Sine oculis homeobox homolog 2)	EBI-21617697	0.35
P61769	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	EBI-21675069	0.35
Q5SSJ5	Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74)	EBI-21734720	0.35
Q2NL82	Pre-rRNA-processing protein TSR1 homolog	EBI-21815364	0.35
P54645	5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)	EBI-16361875	0.35
P80386	5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) (5'-AMP-activated protein kinase 40 kDa subunit)	EBI-16362252	0.35
O95149	Snurportin-1 (RNA U transporter 1)	EBI-15577065	0.44
P52298	Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)	EBI-15798493	0.52
Q09161	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)	EBI-15798552	0.40
Q9BUR4	Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)	EBI-15892338	0.35
P03950	Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5)	EBI-16363282	0.35
Q14684	Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)	EBI-16686997	0.35
P62753	40S ribosomal protein S6 (Phosphoprotein NP33) (Small ribosomal subunit protein eS6)	EBI-16799122	0.35
O94776	Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)	EBI-16803315	0.35
P09622	Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)	EBI-20304669	0.35
P36957	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)	EBI-20305285	0.35
O00429	Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)	EBI-20305770	0.35
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)	EBI-20306067	0.35
P08559	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	EBI-20306509	0.35
P31040	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)	EBI-20306992	0.35
P35610	Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)	EBI-20307233	0.35
P00441	Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1)	EBI-20307497	0.35
P21796	Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)	EBI-20307902	0.35
P51957	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)	EBI-20722397	0.35
P10636	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	EBI-20799058	0.35
A2A935	Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)	EBI-21024514	0.35
P14404	Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein homolog)	EBI-21026252	0.35
P56817	Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)	EBI-20992725	0.35
P04156	Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)	EBI-21014477	0.35
P04233	HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]	EBI-21258980	0.50
Q99558	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)	EBI-21261374	0.50
Q15077	P2Y purinoceptor 6 (P2Y6)	EBI-21262943	0.50
F5H1C8	Solute carrier family 15 member 3 (Solute carrier family 15, member 3, isoform CRA_a)	EBI-21264930	0.50
Q9Y275	Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]	EBI-21266480	0.50
Q9H1C4	Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1)	EBI-21266770	0.50
P42858	Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]	EBI-21132926	0.35
P12004	Proliferating cell nuclear antigen (PCNA) (Cyclin)	EBI-21236861	0.37
Q9NRI5	Disrupted in schizophrenia 1 protein	EBI-30827879	0.59
P09613	Envelopment polyprotein (M polyprotein) (p110) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); Glycoprotein C (Gc) (Glycoprotein G2)]	EBI-21497303	0.35
Q16526	Cryptochrome-1	EBI-21981854	0.35
Q13164	Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)	EBI-25374538	0.35
P11234	Ras-related protein Ral-B (EC 3.6.5.2)	EBI-25376255	0.35
Q92934	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)	EBI-25378368	0.35
P0DOF2	Matrix protein (Phosphoprotein M2)	EBI-25603126	0.35
Q9BY14	Testis-expressed protein 101 (Cell surface receptor NYD-SP8) (Scleroderma-associated autoantigen) (Spermatogenesis-related gene protein)	EBI-25505396	0.35
A0A3G5BIZ0	ORF6 protein (Accessory protein 6) (Non-structural protein 6)	EBI-25565269	0.43
Q9C0B5	Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)	EBI-25636144	0.35
B3CRR2	Ankyrin repeat-containing protein 01_02	EBI-26357604	0.50
B3CTB0	Ankyrin repeat-containing protein 06_02 (Ankyrin repeat-containing protein 06_03) (Ankyrin repeat-containing protein 06_04)	EBI-26357616	0.35
Q53F19	Nuclear cap-binding protein subunit 3 (Protein ELG)	EBI-26396827	0.35
P35226	Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)	EBI-27109494	0.35
Q8N488	RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)	EBI-27111302	0.35
Q99592	Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171)	EBI-27093179	0.35
Q8NCK7	Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11)	EBI-27103180	0.35
Q05D32	CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-)	EBI-27113232	0.35
P0DTC4	Envelope small membrane protein (E) (sM protein)	EBI-28955127	0.35
Q5HYC2	Uncharacterized protein KIAA2026	EBI-30827309	0.44
O96028	Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)	EBI-30827207	0.44
Q6ZQQ2	Spermatogenesis-associated protein 31D1 (Protein FAM75D1)	EBI-30827357	0.44
Q6ZUB0	Spermatogenesis-associated protein 31D4 (Protein FAM75D4)	EBI-30827368	0.44
Q702N8	Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1)	EBI-30827379	0.44
Q7RTY1	Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9)	EBI-30827390	0.44
Q7Z6M1	Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40)	EBI-30827401	0.44
Q8N398	von Willebrand factor A domain-containing protein 5B2	EBI-30827412	0.44
O15397	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)	EBI-30827163	0.44
O43307	Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9)	EBI-30827174	0.44
O43520	Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1)	EBI-30827185	0.44
O15321	Transmembrane 9 superfamily member 1 (MP70 protein family member) (hMP70)	EBI-30827152	0.44
O00750	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)	EBI-30827141	0.44
P0C874	Spermatogenesis-associated protein 31D3 (Protein FAM75D3)	EBI-30827232	0.44
Q5XG87	Terminal nucleotidyltransferase 4A (DNA polymerase sigma) (LAK-1) (Non-canonical poly(A) RNA polymerase PAPD7) (EC 2.7.7.19) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1)	EBI-30827320	0.44
Q9H207	Olfactory receptor 10A5 (HP3) (Olfactory receptor 10A1) (Olfactory receptor 11-403) (OR11-403) (Olfactory receptor-like protein JCG6)	EBI-30827679	0.44
Q9C0D9	Ethanolaminephosphotransferase 1 (hEPT1) (EC 2.7.8.1) (Selenoprotein I) (SelI)	EBI-30827646	0.44
Q9BZ95	Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)	EBI-30827635	0.44
Q96R08	Olfactory receptor 5B12 (Olfactory receptor 5B16) (Olfactory receptor OR11-241)	EBI-30827624	0.44
Q92615	La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5)	EBI-30827577	0.44
Q8NGY0	Olfactory receptor 10X1 (Olfactory receptor OR1-14)	EBI-30827566	0.44
Q8NGI9	Olfactory receptor 5A2 (Olfactory receptor OR11-248)	EBI-30827537	0.44
Q8NGA6	Olfactory receptor 10H5 (Olfactory receptor OR19-25) (Olfactory receptor OR19-26)	EBI-30827526	0.44
Q8N7C0	Leucine-rich repeat-containing protein 52 (BK channel auxiliary gamma subunit LRRC52)	EBI-30827423	0.44
Q8NCP5	Zinc finger and BTB domain-containing protein 44 (BTB/POZ domain-containing protein 15) (Zinc finger protein 851)	EBI-30827434	0.44
Q9H208	Olfactory receptor 10A2 (HP4) (Olfactory receptor OR11-86)	EBI-30827709	0.44
Q8NGA2	Putative olfactory receptor 7A2 (Putative olfactory receptor 7A7)	EBI-30827490	0.44
Q8NG92	Olfactory receptor 13H1 (Olfactory receptor ORX-1)	EBI-30827464	0.44
Q9H6Z4	Ran-binding protein 3 (RanBP3)	EBI-30827857	0.44
Q9NRD1	F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)	EBI-30827868	0.44
Q9Y399	28S ribosomal protein S2, mitochondrial (MRP-S2) (S2mt) (Mitochondrial small ribosomal subunit protein uS2m)	EBI-30827920	0.44
Q9NZP0	Olfactory receptor 6C3 (HSA8)	EBI-30827909	0.44

Cross-References

Database	Links
UNIPROT	Q14974 B7ZAV6 D3DTT3 Q14637 Q53XN2 Q96J27
PDB	1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW 3W5K 6N88 6N89
Pfam	PF03810
PROSITE	PS50077 PS50166
OMIM	602738
DisGeNET	3837

Importin subunit beta-1 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 1F59)

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Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

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Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (51 interactors)

Interactions with other proteins (213 interactors)

Cross-References

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Description

Description